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Q0VSB5 (ILVC_ALCBS) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 41. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Ketol-acid reductoisomerase
EC=1.1.1.86
Alternative name(s):
Acetohydroxy-acid isomeroreductase
Alpha-keto-beta-hydroxylacil reductoisomerase
Gene names
Name:ilvC
Ordered Locus Names:ABO_0485
OrganismAlcanivorax borkumensis (strain SK2 / ATCC 700651 / DSM 11573) [Complete proteome] [HAMAP]
Taxonomic identifier393595 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Oceanospirillales › Alcanivoracaceae › Alcanivorax

Protein attributes

Sequence length338 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

(R)-2,3-dihydroxy-3-methylbutanoate + NADP+ = (S)-2-hydroxy-2-methyl-3-oxobutanoate + NADPH. HAMAP MF_00435

(2R,3R)-2,3-dihydroxy-3-methylpentanoate + NADP+ = (S)-2-hydroxy-2-ethyl-3-oxobutanoate + NADPH. HAMAP MF_00435

Pathway

Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 2/4. HAMAP MF_00435

Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 2/4. HAMAP MF_00435

Sequence similarities

Belongs to the ketol-acid reductoisomerase family.

Sequence caution

The sequence CAL15933.1 differs from that shown. Reason: Erroneous initiation.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 338338Ketol-acid reductoisomerase HAMAP MF_00435
PRO_0000252748

Sites

Active site1071 Potential

Sequences

Sequence LengthMass (Da)Tools
Q0VSB5 [UniParc].

Last modified October 17, 2006. Version 2.
Checksum: 3E503EF2FAFB470F

FASTA33836,297
        10         20         30         40         50         60 
MQVYYDKDCD LSIIQGKKVA ILGYGSQGHA HACNLKDSGV DVVVGLRTGS TSIAKAEAHG 

        70         80         90        100        110        120 
LSVTDVPSAV AAADVVMVLT PDEFQAHLYK SDIEPNLKEG ATLAFAHGFA IHYNQIVPRA 

       130        140        150        160        170        180 
DLDVIMIAPK APGHTVRTEF TKGGGIPDLI AIFQDASGSA KELALSYACG VGGGRTGIIE 

       190        200        210        220        230        240 
TTFKDETETD LFGEQAVLCG GAVELVKAGF ETLTEAGYAP EMAYFECLHE LKLIVDLMYE 

       250        260        270        280        290        300 
GGIANMNYSI SNNAEYGEYV TGPEVINDES RAAMRNALKR IQSGEYAKMF IAEGAHNYPS 

       310        320        330 
MTAARRNNAA HPIEQVGEKL RGMMPWIQAN QIVDKTKN

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AM286690 Genomic DNA. Translation: CAL15933.1. Different initiation.
RefSeqYP_692205.1. NC_008260.1.

3D structure databases

ProteinModelPortalQ0VSB5.
SMRQ0VSB5. Positions 1-327.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ0VSB5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4211352.
GenomeReviewsGene locus ABO_0485 in contig AM286690_GR.
KEGGabo:ABO_0485.
NMPDRfig|393595.12.peg.482.
PATRIC20838603. VBIAlcBor124741_0507.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0059.
HOGENOMHBG286525.
PhylomeDBQ0VSB5.
ProtClustDBPRK05479.

Enzyme and pathway databases

BioCycABOR393595:ABO_0485-MONOMER.

Family and domain databases

HAMAPMF_00435. IlvC.
[Tree]
InterProIPR008927. 6-PGluconate_DH_C-like.
IPR013023. AcH_isomrdctse.
IPR000506. AcH_isomrdctse_C.
IPR013328. DH_multihelical.
IPR013116. IlvN.
[Graphical view]
Gene3DG3DSA:1.10.1040.10. Opine_DH. 1 hit.
KOK00053.
PANTHERPTHR21371. AcH_isomrdctse. 1 hit.
PfamPF01450. IlvC. 1 hit.
PF07991. IlvN. 1 hit.
[Graphical view]
SUPFAMSSF48179. 6DGDH_C_like. 1 hit.
TIGRFAMsTIGR00465. IlvC. 1 hit.
ProtoNetSearch...

Entry information

Entry nameILVC_ALCBS
AccessionPrimary (citable) accession number: Q0VSB5
Entry history
Integrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: October 17, 2006
Last modified: January 25, 2012
This is version 41 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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