Reviewed, UniProtKB/Swiss-Prot Q0VRH1 (PUR7_ALCBS)

Names and origin

Protein names

Recommended name:
    Phosphoribosylaminoimidazole-succinocarboxamide synthase
    EC=6.3.2.6
Alternative name(s):
    SAICAR synthetase

Gene names

Name:	purC
Ordered Locus Names:	ABO_0779

Organism

Alcanivorax borkumensis (strain SK2 / ATCC 700651 / DSM 11573) [Complete proteome] [HAMAP]

Taxonomic identifier

393595 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Oceanospirillales › Alcanivoracaceae › Alcanivorax

Protein attributes

Sequence length	238 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	ATP + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-aspartate = ADP + phosphate + (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate. HAMAP MF_00137
Pathway	Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate: step 1/2. HAMAP MF_00137
Sequence similarities	Belongs to the SAICAR synthetase family.

Ontologies

Keywords
Biological process	Purine biosynthesis
Ligand	ATP-binding Nucleotide-binding
Molecular function	Ligase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	purine nucleotide biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW phosphoribosylaminoimidazolesuccinocarboxamide synthase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 238	238	Phosphoribosylaminoimidazole-succinocarboxamide synthase HAMAP MF_00137		PRO_1000018661

Sequences

	Sequence		Length	Mass (Da)
	Q0VRH1-1 [UniParc]. Last modified September 5, 2006. Version 1. Checksum: EF070B14282C02A4	FASTA	238	26,843
	10 20 30 40 50 60 MEKRDELYAG KAKSVYTTDD EDMLIMLFRD DTSAFDGKKK EALARKGAVN NQFNAAIMEK 70 80 90 100 110 120 LKAAGIPCHF EKTLSATESL VKKLDMIPVE CVVRNIAAGS ICRRLGVEEG LELTPPTFEF 130 140 150 160 170 180 FLKDDDLGDP MVNDFHIRSF GWASDDQVAQ MKTLTFAVND VLKQLFLDGG MLLVDYKLEF 190 200 210 220 230 GMFKGEVLLG DEFSPDGCRL WDKDSREKLD KDRFRQGLGG VVEAYEEVGK RLGMTFEY

References

[1]

"Genome sequence of the ubiquitous hydrocarbon-degrading marine bacterium Alcanivorax borkumensis." Schneiker S., Martins dos Santos V.A.P., Bartels D., Bekel T., Brecht M., Buhrmester J., Chernikova T.N., Denaro R., Ferrer M., Gertler C., Goesmann A., Golyshina O.V., Kaminski F., Khachane A.N., Lang S., Linke B., McHardy A.C., Meyer F. , Nechitaylo T., Puehler A., Regenhardt D., Rupp O., Sabirova J.S., Selbitschka W., Yakimov M.M., Timmis K.N., Vorhoelter F.-J., Weidner S., Kaiser O., Golyshin P.N. Nat. Biotechnol. 24:997-1004(2006) [PubMed: 16878126] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AM286690 Genomic DNA. Translation: CAL16227.1.
RefSeq	YP_692499.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q0VRH1.
Genome annotation databases
GeneID	4211142.
GenomeReviews	Gene locus ABO_0779 in contig AM286690_GR.
KEGG	abo:ABO_0779.
NMPDR	fig|393595.12.peg.783.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q0VRH1.
OMA	TAFNAQK.
Enzyme and pathway databases
BioCyc	ABOR393595:ABO_0779-MON.
Family and domain databases
HAMAP	MF_00137. [Tree]
InterPro	IPR013816. ATP_grasp_subdomain_2. IPR001636. SAICAR_synt. IPR018236. SAICAR_synthetase_CS. [Graphical view]
Gene3D	G3DSA:3.30.470.20. ATP_grasp_subdomain_2. 1 hit.
PANTHER	PTHR11609. SAICAR_synt. 1 hit.
Pfam	PF01259. SAICAR_synt. 1 hit. [Graphical view]
ProDom	PD003043. SAICAR_synt. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR00081. purC. 1 hit.
PROSITE	PS01057. SAICAR_SYNTHETASE_1. 1 hit. PS01058. SAICAR_SYNTHETASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PUR7_ALCBS

Accession

Primary (citable) accession number: Q0VRH1

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	September 5, 2006
Last modified:	November 3, 2009
This is version 25 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)