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Q0VR89 (METE_ALCBS) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 47. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase
EC=2.1.1.14
Alternative name(s):
Cobalamin-independent methionine synthase
Methionine synthase, vitamin-B12 independent isozyme
Gene names
Name:metE
Ordered Locus Names:ABO_0861
OrganismAlcanivorax borkumensis (strain SK2 / ATCC 700651 / DSM 11573) [Complete proteome] [HAMAP]
Taxonomic identifier393595 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Oceanospirillales › Alcanivoracaceae › Alcanivorax

Protein attributes

Sequence length763 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation By similarity. HAMAP MF_00172

Catalytic activity

5-methyltetrahydropteroyltri-L-glutamate + L-homocysteine = tetrahydropteroyltri-L-glutamate + L-methionine. HAMAP MF_00172

Cofactor

Binds 1 zinc ion per subunit By similarity. HAMAP MF_00172

Pathway

Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-methionine from L-homocysteine (MetE route): step 1/1. HAMAP MF_00172

Sequence similarities

Belongs to the vitamin-B12 independent methionine synthase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 7637635-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase HAMAP MF_00172
PRO_1000017217

Sites

Metal binding6501Zinc By similarity
Metal binding6521Zinc By similarity
Metal binding7351Zinc By similarity

Sequences

Sequence LengthMass (Da)Tools
Q0VR89 [UniParc].

Last modified September 5, 2006. Version 1.
Checksum: C69694CA7A5E94A8

FASTA76386,266
        10         20         30         40         50         60 
MTTLHNLGFP RIGARRELKQ AQEAYWAGDL QQSELEHVGK SLRERHWALQ ADAGVDLMPV 

        70         80         90        100        110        120 
GDFAWYDHIL EFSSLLGVVP SRFEQDANAP VNLDTLFRMA RGRAPTGTPA AACEMTKWFD 

       130        140        150        160        170        180 
TNYHYLVPEL AADQTFRIAR ESLFEQVEEA KAQGHNPKPV IPGPLTYLYL SKGDRFEGAE 

       190        200        210        220        230        240 
DSAKLALLDN LIPVYREILQ RFANQGVQWV QIDEPILVLD LPDSWQRAYL RVYDQLASAS 

       250        260        270        280        290        300 
QTKLLLATYF GGLGNNLFTA LELPVHGLHL DRVRGNDDLG QVIPRLGDKV LSLGVINGRN 

       310        320        330        340        350        360 
IWRTDLDAAL DNITALHNEL GDRLWLAPSC SLLHCPVDLE QEDTLDNELK SWLSFAKQKL 

       370        380        390        400        410        420 
EELALLGGAL RGNSNVNSGL QTQRAALQAR GLSSRIHNPA VAQRLADASQ LSRDRVSPFA 

       430        440        450        460        470        480 
ERIAQQQHAL QLPAFPTTTI GSFPQTREIR TARRDWKAGK LNDAQYQQQM QEEIARCIRY 

       490        500        510        520        530        540 
QEEVELDVLV HGEAERNDMV EYFGELLDGF AFTRFGWVQS YGSRCVKPPI IFGDVQRPQA 

       550        560        570        580        590        600 
MTVEWARYAQ SLTHKPVKGM LTGPVTILQW SFVRDDQPRA DTCRQIALAL RDEVQDLEKA 

       610        620        630        640        650        660 
GIKVIQIDEP ALREGLPLRQ EEWTQYLDWA VDCFRLATVS VDDDTQIHTH MCYSEFNDII 

       670        680        690        700        710        720 
EAIAALDADV ITIETSRSNM ELLDAFRDFH YPNDIGPGVY DIHSPNEPDV AWMVQLMEKA 

       730        740        750        760 
AERLPKERLW VNPDCGLKTR KWDETRAALA NMVNAAKQLR QAS

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AM286690 Genomic DNA. Translation: CAL16309.1.
RefSeqYP_692581.1. NC_008260.1.

3D structure databases

ProteinModelPortalQ0VR89.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ0VR89.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4211501.
GenomeReviewsGene locus ABO_0861 in contig AM286690_GR.
KEGGabo:ABO_0861.
NMPDRfig|393595.12.peg.864.
PATRIC20839421. VBIAlcBor124741_0907.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0620.
HOGENOMHBG287495.
OMARNIWRAN.
PhylomeDBQ0VR89.
ProtClustDBPRK05222.

Enzyme and pathway databases

BioCycABOR393595:ABO_0861-MONOMER.

Family and domain databases

HAMAPMF_00172. Meth_synth.
[Tree]
InterProIPR013215. Cbl-indep_Met_Synth_N.
IPR006276. Cobalamin-indep_Met_synthase.
IPR002629. Methionine_synth.
[Graphical view]
KOK00549.
PfamPF08267. Meth_synt_1. 1 hit.
PF01717. Meth_synt_2. 1 hit.
[Graphical view]
PIRSFPIRSF000382. MeTrfase_B12_ind. 1 hit.
TIGRFAMsTIGR01371. Met_syn_B12ind. 1 hit.
ProtoNetSearch...

Entry information

Entry nameMETE_ALCBS
AccessionPrimary (citable) accession number: Q0VR89
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: September 5, 2006
Last modified: January 25, 2012
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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