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Q0VQU1 (LEXA_ALCBS) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 46. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
LexA repressor

EC=3.4.21.88
Gene names
Name:lexA
Ordered Locus Names:ABO_1009
OrganismAlcanivorax borkumensis (strain SK2 / ATCC 700651 / DSM 11573) [Complete proteome] [HAMAP]
Taxonomic identifier393595 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaOceanospirillalesAlcanivoracaceaeAlcanivorax

Protein attributes

Sequence length204 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair By similarity. HAMAP MF_00015

Catalytic activity

Hydrolysis of Ala-|-Gly bond in repressor lexA. HAMAP MF_00015

Subunit structure

Homodimer By similarity. HAMAP MF_00015

Sequence similarities

Belongs to the peptidase S24 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 204204LexA repressor HAMAP MF_00015
PRO_1000001254

Regions

DNA binding29 – 4921H-T-H motif By similarity

Sites

Active site1231For autocatalytic cleavage activity By similarity
Active site1601For autocatalytic cleavage activity By similarity
Site88 – 892Cleavage; by autolysis By similarity

Sequences

Sequence LengthMass (Da)Tools
Q0VQU1 [UniParc].

Last modified September 5, 2006. Version 1.
Checksum: C438585E429D60AC

FASTA20422,493
        10         20         30         40         50         60 
MSSKLTDRQQ QVLDCIRECL KDNGMAPTRA EIADIMGFQS KNAASDHLRA LERKGYIKLH 

        70         80         90        100        110        120 
SDRSRGIQLL DHAYWGEEEL PVVGKVAAGI PIEAIENVER TVPVPQGLFK QRPTYLLKVQ 

       130        140        150        160        170        180 
GDSMVDAGIF DGDLIAVRKS NVARSGEIVV ARIDEEVTVK TLKLNKSSAT LLPANEAYEP 

       190        200 
IKVPADQLII EGIFVGLIRD PNSF 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AM286690 Genomic DNA. Translation: CAL16457.1.
RefSeqYP_692729.1. NC_008260.1.

3D structure databases

ProteinModelPortalQ0VQU1.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ0VQU1.

Protein family/group databases

MEROPSS24.001.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4211543.
GenomeReviewsGene locus ABO_1009 in contig AM286690_GR.
KEGGabo:ABO_1009.
NMPDRfig|393595.12.peg.1016.
PATRIC20839741. VBIAlcBor124741_1061.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1974.
HOGENOMHBG679610.
OMATHRHSPS.
PhylomeDBQ0VQU1.

Enzyme and pathway databases

BioCycABOR393595:ABO_1009-MONOMER.

Family and domain databases

HAMAPMF_00015. LexA.
[Tree]
InterProIPR006199. LexA_DNA-bd_dom.
IPR006200. Pept_S24_LexA.
IPR006197. Peptidase_S24_LexA.
IPR019759. Peptidase_S24_S26.
IPR015927. Peptidase_S24_S26A/B/C.
IPR011056. Peptidase_S24_S26A/B/C_b-rbn.
IPR011991. WHTH_trsnscrt_rep_DNA-bd.
[Graphical view]
Gene3DG3DSA:2.10.109.10. Pept_S24_S26_C. 1 hit.
G3DSA:1.10.10.10. Wing_hlx_DNA_bd. 1 hit.
KOK01356.
PfamPF01726. LexA_DNA_bind. 1 hit.
PF00717. Peptidase_S24. 1 hit.
[Graphical view]
PRINTSPR00726. LEXASERPTASE.
SUPFAMSSF51306. Pept_S24_S26_C. 1 hit.
TIGRFAMsTIGR00498. LexA. 1 hit.
ProtoNetSearch...

Entry information

Entry nameLEXA_ALCBS
AccessionPrimary (citable) accession number: Q0VQU1
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: September 5, 2006
Last modified: January 25, 2012
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Peptidase families

Classification of peptidase families and list of entries

SIMILARITY comments

Index of protein domains and families