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Protein

Beta-hexosaminidase

Gene

nagZ

Organism
Alcanivorax borkumensis (strain ATCC 700651 / DSM 11573 / NCIMB 13689 / SK2)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Plays a role in peptidoglycan recycling by cleaving the terminal beta-1,4-linked N-acetylglucosamine (GlcNAc) from peptide-linked peptidoglycan fragments, giving rise to free GlcNAc, anhydro-N-acetylmuramic acid and anhydro-N-acetylmuramic acid-linked peptides.UniRule annotation

Catalytic activityi

Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.UniRule annotationSAAS annotation

Pathway: peptidoglycan recycling

This protein is involved in the pathway peptidoglycan recycling, which is part of Cell wall biogenesis.UniRule annotationSAAS annotation
View all proteins of this organism that are known to be involved in the pathway peptidoglycan recycling and in Cell wall biogenesis.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei74 – 741SubstrateUniRule annotation
Binding sitei82 – 821SubstrateUniRule annotation
Binding sitei148 – 1481SubstrateUniRule annotation
Sitei189 – 1891Important for catalytic activityUniRule annotation
Active sitei191 – 1911Proton donor/acceptorUniRule annotation
Active sitei261 – 2611NucleophileUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

GlycosidaseUniRule annotationSAAS annotation, Hydrolase

Keywords - Biological processi

Cell cycle, Cell divisionUniRule annotationSAAS annotation, Cell shape, Cell wall biogenesis/degradationUniRule annotationSAAS annotation, Peptidoglycan synthesisUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciABOR393595:GHRI-1045-MONOMER.
UniPathwayiUPA00544.

Protein family/group databases

CAZyiGH3. Glycoside Hydrolase Family 3.

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-hexosaminidaseUniRule annotationSAAS annotation (EC:3.2.1.52UniRule annotationSAAS annotation)
Alternative name(s):
Beta-N-acetylhexosaminidaseUniRule annotation
N-acetyl-beta-glucosaminidaseUniRule annotation
Gene namesi
Name:nagZUniRule annotationImported
Ordered Locus Names:ABO_1018Imported
OrganismiAlcanivorax borkumensis (strain ATCC 700651 / DSM 11573 / NCIMB 13689 / SK2)Imported
Taxonomic identifieri393595 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaOceanospirillalesAlcanivoracaceaeAlcanivorax
ProteomesiUP000008871 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Interactioni

Protein-protein interaction databases

STRINGi393595.ABO_1018.

Structurei

3D structure databases

ProteinModelPortaliQ0VQT2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni178 – 1792Substrate bindingUniRule annotation

Sequence similaritiesi

Belongs to the glycosyl hydrolase 3 family. NagZ subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG1472.
HOGENOMiHOG000248526.
KOiK01207.
OMAiAGFSSYW.
OrthoDBiEOG6BCT06.

Family and domain databases

Gene3Di3.20.20.300. 1 hit.
HAMAPiMF_00364. NagZ.
InterProiIPR022956. Beta_hexosaminidase_bac.
IPR001764. Glyco_hydro_3_N.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PfamiPF00933. Glyco_hydro_3. 1 hit.
[Graphical view]
SUPFAMiSSF51445. SSF51445. 1 hit.

Sequencei

Sequence statusi: Complete.

Q0VQT2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSVYKVAMS ASASPLLMLD LEGLEVSASE KDMLAHPGAG GLILFARNYV
60 70 80 90 100
DRQQLAELVQ QVRAVRPEML IAVDQEGGRV QRFRDGFVRL PPMAALGQRY
110 120 130 140 150
DQAPAQAVGE ATLLGELMAS ELTELDIDIS FAPVLDLDYG NSSVIGDRSF
160 170 180 190 200
HGDADAMIAL AGAFIDGMSA AGMAATGKHF PGHGHVGADS HLELPIDPRP
210 220 230 240 250
LSELEAADMR PFMALAPKLD GIMPAHVIYS AVEQQTAGFS RYWLQTQLRE
260 270 280 290 300
RLGFRGVIFS DDLSMAGAHG VGGYPQRAQA ALEAGCDMVL ACNCCEGAEQ
310 320 330 340
VLDFLGTQNF SGQVPAAGLR ARPRLPMDAQ RRAVAADLAA ALREH
Length:345
Mass (Da):36,802
Last modified:September 5, 2006 - v1
Checksum:i358CF6114C414B4C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM286690 Genomic DNA. Translation: CAL16466.1.
RefSeqiWP_011588302.1. NC_008260.1.
YP_692738.1. NC_008260.1.

Genome annotation databases

EnsemblBacteriaiCAL16466; CAL16466; ABO_1018.
KEGGiabo:ABO_1018.
PATRICi20839759. VBIAlcBor124741_1070.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM286690 Genomic DNA. Translation: CAL16466.1.
RefSeqiWP_011588302.1. NC_008260.1.
YP_692738.1. NC_008260.1.

3D structure databases

ProteinModelPortaliQ0VQT2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi393595.ABO_1018.

Protein family/group databases

CAZyiGH3. Glycoside Hydrolase Family 3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAL16466; CAL16466; ABO_1018.
KEGGiabo:ABO_1018.
PATRICi20839759. VBIAlcBor124741_1070.

Phylogenomic databases

eggNOGiCOG1472.
HOGENOMiHOG000248526.
KOiK01207.
OMAiAGFSSYW.
OrthoDBiEOG6BCT06.

Enzyme and pathway databases

UniPathwayiUPA00544.
BioCyciABOR393595:GHRI-1045-MONOMER.

Family and domain databases

Gene3Di3.20.20.300. 1 hit.
HAMAPiMF_00364. NagZ.
InterProiIPR022956. Beta_hexosaminidase_bac.
IPR001764. Glyco_hydro_3_N.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PfamiPF00933. Glyco_hydro_3. 1 hit.
[Graphical view]
SUPFAMiSSF51445. SSF51445. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700651 / DSM 11573 / NCIMB 13689 / SK2Imported.

Entry informationi

Entry nameiQ0VQT2_ALCBS
AccessioniPrimary (citable) accession number: Q0VQT2
Entry historyi
Integrated into UniProtKB/TrEMBL: September 5, 2006
Last sequence update: September 5, 2006
Last modified: May 27, 2015
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.