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Q0VQP1 (MURB_ALCBS) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 50. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
UDP-N-acetylenolpyruvoylglucosamine reductase
EC=1.1.1.158
Alternative name(s):
UDP-N-acetylmuramate dehydrogenase
Gene names
Name:murB
Ordered Locus Names:ABO_1059
OrganismAlcanivorax borkumensis (strain SK2 / ATCC 700651 / DSM 11573) [Complete proteome] [HAMAP]
Taxonomic identifier393595 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Oceanospirillales › Alcanivoracaceae › Alcanivorax

Protein attributes

Sequence length347 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation By similarity. HAMAP MF_00037

Catalytic activity

UDP-N-acetylmuramate + NADP+ = UDP-N-acetyl-3-O-(1-carboxyvinyl)-D-glucosamine + NADPH. HAMAP MF_00037

Cofactor

FAD By similarity. HAMAP MF_00037

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP MF_00037

Subcellular location

Cytoplasm By similarity HAMAP MF_00037.

Sequence similarities

Belongs to the MurB family.

Contains 1 FAD-binding PCMH-type domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 347347UDP-N-acetylenolpyruvoylglucosamine reductase HAMAP MF_00037
PRO_0000332443

Regions

Domain27 – 197171FAD-binding PCMH-type

Sites

Active site1731 By similarity
Active site2471Proton donor By similarity
Active site3421 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q0VQP1 [UniParc].

Last modified September 5, 2006. Version 1.
Checksum: 6273B282BE5AD225

FASTA34737,370
        10         20         30         40         50         60 
MSESVPPTHT FTQIDDADLT GLNTLGLPAR AQRLARPTTL DALSQVLAER NPAEPLFVIG 

        70         80         90        100        110        120 
EGSNLVICSD LPGLTLSLAI DGMSLVKQDN THVWVAAGAG VHWDDLVAWT VEQGWQGLEN 

       130        140        150        160        170        180 
LSLIPGTVGA APFQNIGAYG VELSQLLEQV TVMDVVTAQV THFAGNECEF AYRDSRFKSR 

       190        200        210        220        230        240 
DRGRYIITGI ELRLNKMPQC NVSYGPLKAR FGHLSQADIL PAAVREHVIA VRQSKLPAPD 

       250        260        270        280        290        300 
VLANAGSFFK NPVVTKERGD ALKRRFADLV AYTQPDGVKL AAGWLIEQAG WKGKRLGPVG 

       310        320        330        340 
MHSEQALVLV NHGNATSADV IALAEAVCAD VQEKFGVALE QEPVLLP

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AM286690 Genomic DNA. Translation: CAL16507.1.
RefSeqYP_692779.1. NC_008260.1.

3D structure databases

ProteinModelPortalQ0VQP1.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ0VQP1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4211240.
GenomeReviewsGene locus ABO_1059 in contig AM286690_GR.
KEGGabo:ABO_1059.
NMPDRfig|393595.12.peg.1067.
PATRIC20839843. VBIAlcBor124741_1112.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0812.
HOGENOMHBG686573.
OMAIEQAGWK.
PhylomeDBQ0VQP1.

Enzyme and pathway databases

BioCycABOR393595:ABO_1059-MONOMER.

Family and domain databases

HAMAPMF_00037. MurB.
[Tree]
InterProIPR016169. CO_DH_flavot_FAD-bd_sub2.
IPR016166. FAD-bd_2.
IPR016167. FAD-bd_2_sub1.
IPR003170. MurB.
IPR011601. MurB_C.
IPR006094. Oxid_FAD_bind_N.
[Graphical view]
Gene3DG3DSA:3.30.465.10. CO_DH_flavoprot_FAD-bd_sub2. 1 hit.
G3DSA:3.30.43.10. FAD-binding_2_sub1. 1 hit.
G3DSA:3.90.78.10. MurB_C. 1 hit.
KOK00075.
PANTHERPTHR21071. MurB. 1 hit.
PfamPF01565. FAD_binding_4. 1 hit.
PF02873. MurB_C. 1 hit.
[Graphical view]
SUPFAMSSF56176. FAD-binding_2. 1 hit.
SSF56194. MurB_C. 1 hit.
TIGRFAMsTIGR00179. MurB. 1 hit.
PROSITEPS51387. FAD_PCMH. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameMURB_ALCBS
AccessionPrimary (citable) accession number: Q0VQP1
Entry history
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: September 5, 2006
Last modified: January 25, 2012
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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