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Q0VQE4

- LPXB_ALCBS

UniProt

Q0VQE4 - LPXB_ALCBS

Protein

Lipid-A-disaccharide synthase

Gene

lpxB

Organism
Alcanivorax borkumensis (strain SK2 / ATCC 700651 / DSM 11573)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 47 (01 Oct 2014)
      Sequence version 1 (05 Sep 2006)
      Previous versions | rss
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    Functioni

    Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.UniRule annotation

    Catalytic activityi

    UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. lipid-A-disaccharide synthase activity Source: UniProtKB-EC

    GO - Biological processi

    1. lipid A biosynthetic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Keywords - Biological processi

    Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

    Enzyme and pathway databases

    BioCyciABOR393595:GHRI-1183-MONOMER.
    UniPathwayiUPA00359; UER00481.

    Protein family/group databases

    CAZyiGT19. Glycosyltransferase Family 19.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Lipid-A-disaccharide synthaseUniRule annotation (EC:2.4.1.182UniRule annotation)
    Gene namesi
    Name:lpxBUniRule annotation
    Ordered Locus Names:ABO_1156
    OrganismiAlcanivorax borkumensis (strain SK2 / ATCC 700651 / DSM 11573)
    Taxonomic identifieri393595 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaOceanospirillalesAlcanivoracaceaeAlcanivorax
    ProteomesiUP000008871: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 383383Lipid-A-disaccharide synthasePRO_0000255158Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi393595.ABO_1156.

    Structurei

    3D structure databases

    ProteinModelPortaliQ0VQE4.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the LpxB family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0763.
    HOGENOMiHOG000018003.
    KOiK00748.
    OMAiVSPITYR.
    OrthoDBiEOG6FBWZR.

    Family and domain databases

    HAMAPiMF_00392. LpxB.
    InterProiIPR003835. Glyco_trans_19.
    [Graphical view]
    PfamiPF02684. LpxB. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00215. lpxB. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q0VQE4-1 [UniParc]FASTAAdd to Basket

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    MTQRKDAPLV ALIAGEASGD ILGAGLMQAL ENRYPGARFI GVGGEEMAQA    50
    GLTSLFPMEK LSVMGITEVL SHLPELLRLR KSLVRFLLEQ RPDVVVGIDS 100
    PDFTLPIARR LHDRGLKTVH YVSPSVWAWR QGRIKGIKKS IDLMLTLLPF 150
    EARFYEEHDV PVAFVGHPLA DRIPLETDVA GARKALALDR DARILAVLPG 200
    SRGGEVGQLM PAFLDAMVAL NHQDPTLQYV IPAANAARRE QIQTLLNTQP 250
    NLPVSLIDGQ SRTVMAAADV VLMASGTATL EGLLLNKPMV VGYRVGAVTY 300
    AIVSRLIKSE FFSLPNLLCR QEMVPELLQS QLTTEAIVAA VRRWFDQPEQ 350
    AQALKIQFQS VHQQLRGGAS EKAAAAVARL LEA 383
    Length:383
    Mass (Da):41,810
    Last modified:September 5, 2006 - v1
    Checksum:i3DA69039A84750D2
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM286690 Genomic DNA. Translation: CAL16604.1.
    RefSeqiYP_692876.1. NC_008260.1.

    Genome annotation databases

    EnsemblBacteriaiCAL16604; CAL16604; ABO_1156.
    GeneIDi4211461.
    KEGGiabo:ABO_1156.
    PATRICi20840051. VBIAlcBor124741_1216.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM286690 Genomic DNA. Translation: CAL16604.1 .
    RefSeqi YP_692876.1. NC_008260.1.

    3D structure databases

    ProteinModelPortali Q0VQE4.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 393595.ABO_1156.

    Protein family/group databases

    CAZyi GT19. Glycosyltransferase Family 19.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAL16604 ; CAL16604 ; ABO_1156 .
    GeneIDi 4211461.
    KEGGi abo:ABO_1156.
    PATRICi 20840051. VBIAlcBor124741_1216.

    Phylogenomic databases

    eggNOGi COG0763.
    HOGENOMi HOG000018003.
    KOi K00748.
    OMAi VSPITYR.
    OrthoDBi EOG6FBWZR.

    Enzyme and pathway databases

    UniPathwayi UPA00359 ; UER00481 .
    BioCyci ABOR393595:GHRI-1183-MONOMER.

    Family and domain databases

    HAMAPi MF_00392. LpxB.
    InterProi IPR003835. Glyco_trans_19.
    [Graphical view ]
    Pfami PF02684. LpxB. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00215. lpxB. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: SK2 / ATCC 700651 / DSM 11573.

    Entry informationi

    Entry nameiLPXB_ALCBS
    AccessioniPrimary (citable) accession number: Q0VQE4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 31, 2006
    Last sequence update: September 5, 2006
    Last modified: October 1, 2014
    This is version 47 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3