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Q0VQE4

- LPXB_ALCBS

UniProt

Q0VQE4 - LPXB_ALCBS

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Protein
Lipid-A-disaccharide synthase
Gene
lpxB, ABO_1156
Organism
Alcanivorax borkumensis (strain SK2 / ATCC 700651 / DSM 11573)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell By similarity.UniRule annotation

Catalytic activityi

UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. lipid-A-disaccharide synthase activity Source: UniProtKB-EC

GO - Biological processi

  1. lipid A biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

BioCyciABOR393595:GHRI-1183-MONOMER.
UniPathwayiUPA00359; UER00481.

Protein family/group databases

CAZyiGT19. Glycosyltransferase Family 19.

Names & Taxonomyi

Protein namesi
Recommended name:
Lipid-A-disaccharide synthase (EC:2.4.1.182)
Gene namesi
Name:lpxB
Ordered Locus Names:ABO_1156
OrganismiAlcanivorax borkumensis (strain SK2 / ATCC 700651 / DSM 11573)
Taxonomic identifieri393595 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaOceanospirillalesAlcanivoracaceaeAlcanivorax
ProteomesiUP000008871: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 383383Lipid-A-disaccharide synthaseUniRule annotation
PRO_0000255158Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi393595.ABO_1156.

Structurei

3D structure databases

ProteinModelPortaliQ0VQE4.

Family & Domainsi

Sequence similaritiesi

Belongs to the LpxB family.

Phylogenomic databases

eggNOGiCOG0763.
HOGENOMiHOG000018003.
KOiK00748.
OMAiVSPITYR.
OrthoDBiEOG6FBWZR.

Family and domain databases

HAMAPiMF_00392. LpxB.
InterProiIPR003835. Glyco_trans_19.
[Graphical view]
PfamiPF02684. LpxB. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00215. lpxB. 1 hit.

Sequencei

Sequence statusi: Complete.

Q0VQE4-1 [UniParc]FASTAAdd to Basket

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MTQRKDAPLV ALIAGEASGD ILGAGLMQAL ENRYPGARFI GVGGEEMAQA    50
GLTSLFPMEK LSVMGITEVL SHLPELLRLR KSLVRFLLEQ RPDVVVGIDS 100
PDFTLPIARR LHDRGLKTVH YVSPSVWAWR QGRIKGIKKS IDLMLTLLPF 150
EARFYEEHDV PVAFVGHPLA DRIPLETDVA GARKALALDR DARILAVLPG 200
SRGGEVGQLM PAFLDAMVAL NHQDPTLQYV IPAANAARRE QIQTLLNTQP 250
NLPVSLIDGQ SRTVMAAADV VLMASGTATL EGLLLNKPMV VGYRVGAVTY 300
AIVSRLIKSE FFSLPNLLCR QEMVPELLQS QLTTEAIVAA VRRWFDQPEQ 350
AQALKIQFQS VHQQLRGGAS EKAAAAVARL LEA 383
Length:383
Mass (Da):41,810
Last modified:September 5, 2006 - v1
Checksum:i3DA69039A84750D2
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM286690 Genomic DNA. Translation: CAL16604.1.
RefSeqiYP_692876.1. NC_008260.1.

Genome annotation databases

EnsemblBacteriaiCAL16604; CAL16604; ABO_1156.
GeneIDi4211461.
KEGGiabo:ABO_1156.
PATRICi20840051. VBIAlcBor124741_1216.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM286690 Genomic DNA. Translation: CAL16604.1 .
RefSeqi YP_692876.1. NC_008260.1.

3D structure databases

ProteinModelPortali Q0VQE4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 393595.ABO_1156.

Protein family/group databases

CAZyi GT19. Glycosyltransferase Family 19.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAL16604 ; CAL16604 ; ABO_1156 .
GeneIDi 4211461.
KEGGi abo:ABO_1156.
PATRICi 20840051. VBIAlcBor124741_1216.

Phylogenomic databases

eggNOGi COG0763.
HOGENOMi HOG000018003.
KOi K00748.
OMAi VSPITYR.
OrthoDBi EOG6FBWZR.

Enzyme and pathway databases

UniPathwayi UPA00359 ; UER00481 .
BioCyci ABOR393595:GHRI-1183-MONOMER.

Family and domain databases

HAMAPi MF_00392. LpxB.
InterProi IPR003835. Glyco_trans_19.
[Graphical view ]
Pfami PF02684. LpxB. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00215. lpxB. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SK2 / ATCC 700651 / DSM 11573.

Entry informationi

Entry nameiLPXB_ALCBS
AccessioniPrimary (citable) accession number: Q0VQE4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: September 5, 2006
Last modified: May 14, 2014
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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