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Reviewed, UniProtKB/Swiss-Prot Q0VQC3 (PDXB_ALCBS)

Last modified June 16, 2009. Version 27. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Erythronate-4-phosphate dehydrogenase
    EC=1.1.1.290
Gene names
Name: pdxB
Ordered Locus Names: ABO_1177
OrganismAlcanivorax borkumensis (strain SK2 / ATCC 700651 / DSM 11573) [Complete proteome] [HAMAP]
Taxonomic identifier393595 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Oceanospirillales › Alcanivoracaceae › Alcanivorax

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Protein attributes

Sequence length371 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

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General annotation (Comments)

Function

Catalyzes the oxidation of erythronate-4-phosphate to 3-hydroxy-2-oxo-4-phosphonooxybutanoate By similarity.

Catalytic activity

4-phospho-D-erythronate + NAD+ = (3R)-3-hydroxy-2-oxo-4-phosphonooxybutanoate + NADH. HAMAP MF_01825

Pathway

Cofactor biosynthesis; pyridoxine 5'-phosphate biosynthesis; pyridoxine 5'-phosphate from D-erythrose 4-phosphate: step 2/5. HAMAP MF_01825

Subunit structure

Homodimer By similarity.

Subcellular location

Cytoplasm Potential.

Sequence similarities

Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. PdxB subfamily.

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Ontologies

Keywords
   Biological processPyridoxine biosynthesis
   Cellular componentCytoplasm
   LigandNAD
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processoxidation reduction

Inferred from electronic annotation. Source: UniProtKB-KW

pyridoxine biosynthetic process

Inferred from electronic annotation. Source: HAMAP

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular function4-phosphoerythronate dehydrogenase activity

Inferred from electronic annotation. Source: EC

NAD or NADH binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 371371Erythronate-4-phosphate dehydrogenase HAMAP MF_01825
PRO_0000297432

Sites

Active site2081 By similarity
Active site2371 By similarity
Active site2541Proton donor By similarity
Binding site441Substrate By similarity
Binding site651Substrate By similarity
Binding site1451NAD By similarity
Binding site2321NAD By similarity
Binding site2571NAD; via amide nitrogen By similarity
Binding site2581Substrate By similarity

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Sequences

Sequence LengthMass (Da)Tools
Q0VQC3-1 [UniParc].

Last modified July 24, 2007. Version 2.
Checksum: FDD804685E481E99

FASTA37139,938
        10         20         30         40         50         60 
MHIIADANMP GLEPFEAFAT VERVDGRSLT REQLGDADVL LVRSVTRVDR ALLAGSQVKF 

        70         80         90        100        110        120 
VGSATIGTDH VDLAYLSEAG IQFAHAPGCN ARAVAEYVLQ AVLLLCARQG REVQGARVAV 

       130        140        150        160        170        180 
VGLGNVGRRV ADWLSALGME VRGCDPLLDA QGYAGPVALA PLDDLLDADI ITLHVPLTQS 

       190        200        210        220        230        240 
GEHATGHLLD ASRLSRLGPG QMLINTCRGP VIDNLALSQQ LASGTGPMTV LDVWETEPQV 

       250        260        270        280        290        300 
PATLYQQVVM GSPHIAGYSL EGKLKGTSML YDAVCQWSGQ GIASGTAMAD APPLNPAVNS 

       310        320        330        340        350        360 
EADLLALLQV AYRLEDDHRR LGESLHDTDP SAAFDRLRKH YPVRHELHYW QYDGSVDDTW 

       370 
RAIISRLFEP D

« Hide

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Cross-references

Sequence databases

AM286690 Genomic DNA. Translation: CAL16625.1. Different initiation.
RefSeqYP_692897.1.

3D structure databases

ModBaseSearch...

Genome annotation databases

GeneID4212449.
GenomeReviewsGene locus ABO_1177 in contig AM286690_GR.
KEGGabo:ABO_1177.
NMPDRfig|393595.12.peg.1189.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMQ0VQC3.

Enzyme and pathway databases

BioCycABOR393595:ABO_1177-MON.

Family and domain databases

HAMAPMF_01825.
[Tree]
InterProIPR006139. D-isomer_2_OHA_DH.
IPR006140. D-isomer_2_OHA_DH_NAD-bd.
[Graphical view]
PfamPF00389. 2-Hacid_dh. 1 hit.
PF02826. 2-Hacid_dh_C. 1 hit.
[Graphical view]
PROSITEPS00065. D_2_HYDROXYACID_DH_1. 1 hit.
PS00670. D_2_HYDROXYACID_DH_2. False negative.
PS00671. D_2_HYDROXYACID_DH_3. False negative.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry namePDXB_ALCBS
AccessionPrimary (citable) accession number: Q0VQC3
Entry history
Integrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: July 24, 2007
Last modified: June 16, 2009
This is version 27 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

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Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents