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Q0VPI7 (TRUA_ALCBS) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 61. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
tRNA pseudouridine synthase A

EC=5.4.99.12
Alternative name(s):
tRNA pseudouridine(38-40) synthase
tRNA pseudouridylate synthase I
tRNA-uridine isomerase I
Gene names
Name:truA
Ordered Locus Names:ABO_1463
OrganismAlcanivorax borkumensis (strain SK2 / ATCC 700651 / DSM 11573) [Complete proteome] [HAMAP]
Taxonomic identifier393595 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaOceanospirillalesAlcanivoracaceaeAlcanivorax

Protein attributes

Sequence length267 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs By similarity. HAMAP-Rule MF_00171

Catalytic activity

tRNA uridine(38-40) = tRNA pseudouridine(38-40). HAMAP-Rule MF_00171

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_00171

Sequence similarities

Belongs to the tRNA pseudouridine synthase TruA family.

Ontologies

Keywords
   Biological processtRNA processing
   Molecular functionIsomerase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processtRNA pseudouridine synthesis

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Molecular_functionRNA binding

Inferred from electronic annotation. Source: InterPro

pseudouridine synthase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 267267tRNA pseudouridine synthase A HAMAP-Rule MF_00171
PRO_1000194525

Sites

Active site531Nucleophile By similarity
Binding site1111Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q0VPI7 [UniParc].

Last modified October 3, 2006. Version 1.
Checksum: 0E9DAAD5BBE4F2D0

FASTA26729,914
        10         20         30         40         50         60 
MTRIALGIEY DGTDFRGWQM QQSGVRTVQE CLEAALSKVA NHSVTVVCAG RTDAGVHGTG 

        70         80         90        100        110        120 
QVVHFDSDAP REMKSWIMGG NTNLPRDVTI RWAVPVSDDF HARFSAVSRR YRYVIYNHAR 

       130        140        150        160        170        180 
PPALYRSQVT WNHRPLDVAA MREAASYLVG HHDFTAYRSV HCQAKSPLKT LHSLELYEQG 

       190        200        210        220        230        240 
KVLVLEAHAN AFLMHMVRNI AGVLMKVGAG KKPPVWAKDV LECRDRRLGA ATAPPFGLYL 

       250        260 
VEIEYPELFA LPDEPLGPLW LPDRLEA 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AM286690 Genomic DNA. Translation: CAL16911.1.
RefSeqYP_693183.1. NC_008260.1.

3D structure databases

ProteinModelPortalQ0VPI7.
SMRQ0VPI7. Positions 1-263.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING393595.ABO_1463.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAL16911; CAL16911; ABO_1463.
GeneID4211824.
KEGGabo:ABO_1463.
PATRIC20840707. VBIAlcBor124741_1535.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0101.
HOGENOMHOG000248672.
KOK06173.
OMAQANAFVH.
OrthoDBEOG6Z9B4R.
ProtClustDBPRK00021.

Enzyme and pathway databases

BioCycABOR393595:GHRI-1499-MONOMER.

Family and domain databases

Gene3D3.30.70.580. 1 hit.
3.30.70.660. 1 hit.
HAMAPMF_00171. TruA.
InterProIPR020103. PsdUridine_synth_cat_dom.
IPR001406. PsdUridine_synth_TruA.
IPR020097. PsdUridine_synth_TruA_a/b_dom.
IPR020095. PsdUridine_synth_TruA_C.
IPR020094. PsdUridine_synth_TruA_N.
[Graphical view]
PANTHERPTHR11142. PTHR11142. 1 hit.
PfamPF01416. PseudoU_synth_1. 2 hits.
[Graphical view]
PIRSFPIRSF001430. tRNA_psdUrid_synth. 1 hit.
SUPFAMSSF55120. SSF55120. 1 hit.
TIGRFAMsTIGR00071. hisT_truA. 1 hit.
ProtoNetSearch...

Entry information

Entry nameTRUA_ALCBS
AccessionPrimary (citable) accession number: Q0VPI7
Entry history
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: October 3, 2006
Last modified: February 19, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families