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Protein

Glutamate--tRNA ligase

Gene

gltX

Organism
Alcanivorax borkumensis (strain ATCC 700651 / DSM 11573 / NCIMB 13689 / SK2)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).UniRule annotation

Catalytic activityi

ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei253ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciABOR393595:G1G1O-1570-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate--tRNA ligaseUniRule annotation (EC:6.1.1.17UniRule annotation)
Alternative name(s):
Glutamyl-tRNA synthetaseUniRule annotation
Short name:
GluRSUniRule annotation
Gene namesi
Name:gltXUniRule annotation
Ordered Locus Names:ABO_1509
OrganismiAlcanivorax borkumensis (strain ATCC 700651 / DSM 11573 / NCIMB 13689 / SK2)
Taxonomic identifieri393595 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaOceanospirillalesAlcanivoracaceaeAlcanivorax
Proteomesi
  • UP000008871 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000018691 – 494Glutamate--tRNA ligaseAdd BLAST494

Proteomic databases

PRIDEiQ0VPE1

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi393595.ABO_1509

Structurei

3D structure databases

ProteinModelPortaliQ0VPE1
SMRiQ0VPE1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi9 – 19"HIGH" regionUniRule annotationAdd BLAST11
Motifi250 – 254"KMSKS" regionUniRule annotation5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C20 Bacteria
COG0008 LUCA
HOGENOMiHOG000252720
KOiK01885
OMAiHYINTLP
OrthoDBiPOG091H021W

Family and domain databases

CDDicd00808 GluRS_core, 1 hit
Gene3Di1.10.10.350, 1 hit
3.40.50.620, 1 hit
HAMAPiMF_00022 Glu_tRNA_synth_type1, 1 hit
InterProiView protein in InterPro
IPR008925 aa-tRNA-synth_I_codon-bd
IPR020751 aa-tRNA-synth_I_codon-bd_sub2
IPR001412 aa-tRNA-synth_I_CS
IPR004527 Glu-tRNA-ligase_bac/mito
IPR000924 Glu/Gln-tRNA-synth
IPR020058 Glu/Gln-tRNA-synth_Ib_cat-dom
IPR033910 GluRS_core
IPR014729 Rossmann-like_a/b/a_fold
PfamiView protein in Pfam
PF00749 tRNA-synt_1c, 1 hit
PRINTSiPR00987 TRNASYNTHGLU
SUPFAMiSSF48163 SSF48163, 1 hit
TIGRFAMsiTIGR00464 gltX_bact, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

Q0VPE1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTVRTRVAPS PTGDPHVGTA YIALFNRCFA QQHGGQFILR IEDTDQTRST
60 70 80 90 100
DQSEQMILDS LKWLGLTWDE GPDVGGPHGP YRQSERKGIY RQYAEQLIEK
110 120 130 140 150
GHAFKCYRTS EELDALRAGL KESGENRALK PSDLELPADE QAKREADGAP
160 170 180 190 200
YVIRMRVPTE GRCEIHDMLR GPVELDWALV DAQILLKSDG MPTYHLANIV
210 220 230 240 250
DDHLMEITHV IRGEEWLNSA PKHKLLYEYF GWEMPVLCHM PLLRNPDKSK
260 270 280 290 300
LSKRKNPTSI LFYQRMGYLP EALVNYLGRM GWSMPDESEK FSLTQMQEAF
310 320 330 340 350
DIQRVSLGGP VFDVEKLSWL NGQWLREQSD EQFLDSLLDW AFNRDYAMKI
360 370 380 390 400
IPHLRQRVET LSEVADKAAF CFNGMPAISE ASFEHKQYSA DDIKVWLQYL
410 420 430 440 450
LWTYEARNDW NREGLFADAK AIADALEVKI KDFLFPVFIA IAGTSASFSV
460 470 480 490
VDSMEIIGSD ISRARIRHAI EVLGGVSKKQ MKKLEKAYRD LPVG
Length:494
Mass (Da):56,468
Last modified:September 5, 2006 - v1
Checksum:i32C953A2EC735CBE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM286690 Genomic DNA Translation: CAL16957.1
RefSeqiWP_011588790.1, NC_008260.1

Genome annotation databases

EnsemblBacteriaiCAL16957; CAL16957; ABO_1509
KEGGiabo:ABO_1509

Similar proteinsi

Entry informationi

Entry nameiSYE_ALCBS
AccessioniPrimary (citable) accession number: Q0VPE1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: September 5, 2006
Last modified: March 28, 2018
This is version 83 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health