Reviewed, UniProtKB/Swiss-Prot Q0VP77 (PUR5_ALCBS)

Names and origin

Protein names

Recommended name:
    Phosphoribosylformylglycinamidine cyclo-ligase
    EC=6.3.3.1
Alternative name(s):
    AIRS
    Phosphoribosyl-aminoimidazole synthetase
    AIR synthase

Gene names

Name:	purM
Ordered Locus Names:	ABO_1573

Organism

Alcanivorax borkumensis (strain SK2 / ATCC 700651 / DSM 11573) [Complete proteome] [HAMAP]

Taxonomic identifier

393595 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Oceanospirillales › Alcanivoracaceae › Alcanivorax

Protein attributes

Sequence length	347 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	ATP + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole. HAMAP MF_00741
Pathway	Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 2/2. HAMAP MF_00741
Subcellular location	Cytoplasm By similarity HAMAP MF_00741.
Sequence similarities	Belongs to the AIR synthase family.

Ontologies

Keywords
Biological process	Purine biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Ligase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	'de novo' IMP biosynthetic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW phosphoribosylformylglycinamidine cyclo-ligase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 347	347	Phosphoribosylformylglycinamidine cyclo-ligase HAMAP MF_00741		PRO_0000258325

Sequences

	Sequence		Length	Mass (Da)
	Q0VP77-1 [UniParc]. Last modified September 5, 2006. Version 1. Checksum: BA0167CA0E880676	FASTA	347	36,921
	10 20 30 40 50 60 MTEQKRPLTY RDAGVDIDAG NELVKRIAPV AKRTRRPEVL GGLGGFGALC ELPTKYKNPV 70 80 90 100 110 120 LVAGTDGVGT KLRLAIDHNR HEKVGVDLVA MCVNDLIVGG AEPLFFLDYY ATGKLDVEIA 130 140 150 160 170 180 TSVVTGIGEG CELAGCALIG GETAEMPGMY EGEDYDLAGF CVGVVEKDGV LDGSKVEAGD 190 200 210 220 230 240 KLIGLGASGP HSNGYSLIRR IMAQAETDID LDGKPLIEHL LEPTRIYVKS LLKLIEQVPV 250 260 270 280 290 300 HAMAHITGGG LPENLPRVLP DNTRAVIDTK SWEFPAVFQW LQQEGQVPAF EMYRTFNCGV 310 320 330 340 GMVIAVPASH VDDALALLEA EGESAFLIGE IQAGDGQPDV VLDGLSA

References

[1]

"Genome sequence of the ubiquitous hydrocarbon-degrading marine bacterium Alcanivorax borkumensis." Schneiker S., Martins dos Santos V.A.P., Bartels D., Bekel T., Brecht M., Buhrmester J., Chernikova T.N., Denaro R., Ferrer M., Gertler C., Goesmann A., Golyshina O.V., Kaminski F., Khachane A.N., Lang S., Linke B., McHardy A.C., Meyer F. , Nechitaylo T., Puehler A., Regenhardt D., Rupp O., Sabirova J.S., Selbitschka W., Yakimov M.M., Timmis K.N., Vorhoelter F.-J., Weidner S., Kaiser O., Golyshin P.N. Nat. Biotechnol. 24:997-1004(2006) [PubMed: 16878126] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AM286690 Genomic DNA. Translation: CAL17021.1.
RefSeq	YP_693293.1.
3D structure databases
SMR	Q0VP77. Positions 8-343.
ModBase	Search...
Protein-protein interaction databases
STRING	Q0VP77.
Genome annotation databases
GeneID	4211149.
GenomeReviews	Gene locus ABO_1573 in contig AM286690_GR.
KEGG	abo:ABO_1573.
NMPDR	fig|393595.12.peg.1578.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0150.
HOGENOM	HBG531222.
OMA	HYDLAGF.
PhylomeDB	Q0VP77.
Enzyme and pathway databases
BioCyc	ABOR393595:ABO_1573-MONOMER.
Family and domain databases
HAMAP	MF_00741_B. AIRS_B. [Tree]
InterPro	IPR000728. AIR_synth. IPR010918. AIR_synth_C. IPR004733. PurM_cligase. IPR016188. PurM_N-like. [Graphical view]
Pfam	PF00586. AIRS. 1 hit. PF02769. AIRS_C. 1 hit. [Graphical view]
TIGRFAMs	TIGR00878. purM. 1 hit.
ProtoNet	Search...

Entry information

Entry name

PUR5_ALCBS

Accession

Primary (citable) accession number: Q0VP77

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 31, 2006
Last sequence update:	September 5, 2006
Last modified:	February 9, 2010
This is version 30 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)