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Q0VP22

- PDXJ_ALCBS

UniProt

Q0VP22 - PDXJ_ALCBS

Protein

Pyridoxine 5'-phosphate synthase

Gene

pdxJ

Organism
Alcanivorax borkumensis (strain SK2 / ATCC 700651 / DSM 11573)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 55 (01 Oct 2014)
      Sequence version 1 (05 Sep 2006)
      Previous versions | rss
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    Functioni

    Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate.UniRule annotation

    Catalytic activityi

    1-deoxy-D-xylulose 5-phosphate + 3-amino-2-oxopropyl phosphate = pyridoxine 5'-phosphate + phosphate + 2 H2O.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei12 – 1213-amino-2-oxopropyl phosphateUniRule annotation
    Binding sitei23 – 2313-amino-2-oxopropyl phosphateUniRule annotation
    Active sitei48 – 481Proton acceptorUniRule annotation
    Binding sitei50 – 5011-deoxy-D-xylulose 5-phosphateUniRule annotation
    Binding sitei55 – 5511-deoxy-D-xylulose 5-phosphateUniRule annotation
    Active sitei75 – 751Proton acceptorUniRule annotation
    Binding sitei105 – 10511-deoxy-D-xylulose 5-phosphateUniRule annotation
    Sitei156 – 1561Transition state stabilizerUniRule annotation
    Active sitei196 – 1961Proton donorUniRule annotation
    Binding sitei197 – 19713-amino-2-oxopropyl phosphate; via amide nitrogenUniRule annotation

    GO - Molecular functioni

    1. pyridoxine 5'-phosphate synthase activity Source: UniProtKB-EC

    GO - Biological processi

    1. pyridoxine biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Transferase

    Keywords - Biological processi

    Pyridoxine biosynthesis

    Enzyme and pathway databases

    BioCyciABOR393595:GHRI-1668-MONOMER.
    UniPathwayiUPA00244; UER00313.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Pyridoxine 5'-phosphate synthaseUniRule annotation (EC:2.6.99.2UniRule annotation)
    Short name:
    PNP synthaseUniRule annotation
    Gene namesi
    Name:pdxJUniRule annotation
    Ordered Locus Names:ABO_1628
    OrganismiAlcanivorax borkumensis (strain SK2 / ATCC 700651 / DSM 11573)
    Taxonomic identifieri393595 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaOceanospirillalesAlcanivoracaceaeAlcanivorax
    ProteomesiUP000008871: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 244244Pyridoxine 5'-phosphate synthasePRO_1000059228Add
    BLAST

    Interactioni

    Subunit structurei

    Homooctamer; tetramer of dimers.UniRule annotation

    Protein-protein interaction databases

    STRINGi393595.ABO_1628.

    Structurei

    3D structure databases

    ProteinModelPortaliQ0VP22.
    SMRiQ0VP22. Positions 5-241.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni14 – 1521-deoxy-D-xylulose 5-phosphate bindingUniRule annotation
    Regioni218 – 21923-amino-2-oxopropyl phosphate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the PNP synthase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0854.
    HOGENOMiHOG000258094.
    KOiK03474.
    OMAiVPETRQE.
    OrthoDBiEOG6M9F0H.

    Family and domain databases

    Gene3Di3.20.20.70. 1 hit.
    HAMAPiMF_00279. PdxJ.
    InterProiIPR013785. Aldolase_TIM.
    IPR004569. PyrdxlP_synth_PdxJ.
    [Graphical view]
    PfamiPF03740. PdxJ. 1 hit.
    [Graphical view]
    SUPFAMiSSF63892. SSF63892. 1 hit.
    TIGRFAMsiTIGR00559. pdxJ. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q0VP22-1 [UniParc]FASTAAdd to Basket

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    MSFMSRVLLG VNIDHIATLR QARGTRYPEP VQAALVAEQA GADGITVHLR    50
    EDRRHINDRD VELLAQTLQT RMNLEMAATE EMVVIACRIQ PPHCCLVPEK 100
    REELTTEGGL DVVGNKAWIA QCCQRLGQAG IEVSLFIDAE ESQILAAREC 150
    GAPAIEIHTG GYADAQTIDQ QQQELARIRS AVAFALAQGL IVNAGHGLHY 200
    HNTLAIAEIP GINELNIGHS IIARAAITGL DEAVRSMRSL LDTV 244
    Length:244
    Mass (Da):26,509
    Last modified:September 5, 2006 - v1
    Checksum:iCC67C57A7AED532B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM286690 Genomic DNA. Translation: CAL17076.1.
    RefSeqiYP_693348.1. NC_008260.1.

    Genome annotation databases

    EnsemblBacteriaiCAL17076; CAL17076; ABO_1628.
    GeneIDi4212451.
    KEGGiabo:ABO_1628.
    PATRICi20841055. VBIAlcBor124741_1705.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM286690 Genomic DNA. Translation: CAL17076.1 .
    RefSeqi YP_693348.1. NC_008260.1.

    3D structure databases

    ProteinModelPortali Q0VP22.
    SMRi Q0VP22. Positions 5-241.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 393595.ABO_1628.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAL17076 ; CAL17076 ; ABO_1628 .
    GeneIDi 4212451.
    KEGGi abo:ABO_1628.
    PATRICi 20841055. VBIAlcBor124741_1705.

    Phylogenomic databases

    eggNOGi COG0854.
    HOGENOMi HOG000258094.
    KOi K03474.
    OMAi VPETRQE.
    OrthoDBi EOG6M9F0H.

    Enzyme and pathway databases

    UniPathwayi UPA00244 ; UER00313 .
    BioCyci ABOR393595:GHRI-1668-MONOMER.

    Family and domain databases

    Gene3Di 3.20.20.70. 1 hit.
    HAMAPi MF_00279. PdxJ.
    InterProi IPR013785. Aldolase_TIM.
    IPR004569. PyrdxlP_synth_PdxJ.
    [Graphical view ]
    Pfami PF03740. PdxJ. 1 hit.
    [Graphical view ]
    SUPFAMi SSF63892. SSF63892. 1 hit.
    TIGRFAMsi TIGR00559. pdxJ. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: SK2 / ATCC 700651 / DSM 11573.

    Entry informationi

    Entry nameiPDXJ_ALCBS
    AccessioniPrimary (citable) accession number: Q0VP22
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 5, 2008
    Last sequence update: September 5, 2006
    Last modified: October 1, 2014
    This is version 55 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3