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Q0VNE1 (SYH_ALCBS) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 41. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Histidine--tRNA ligase
EC=6.1.1.21
Alternative name(s):
Histidyl-tRNA synthetase
Short name=HisRS
Gene names
Name:hisS
Ordered Locus Names:ABO_1859
OrganismAlcanivorax borkumensis (strain SK2 / ATCC 700651 / DSM 11573) [Complete proteome] [HAMAP]
Taxonomic identifier393595 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Oceanospirillales › Alcanivoracaceae › Alcanivorax

Protein attributes

Sequence length422 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-histidine + tRNA(His) = AMP + diphosphate + L-histidyl-tRNA(His). HAMAP MF_00127

Subunit structure

Homodimer By similarity. HAMAP MF_00127

Subcellular location

Cytoplasm By similarity HAMAP MF_00127.

Sequence similarities

Belongs to the class-II aminoacyl-tRNA synthetase family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionAminoacyl-tRNA synthetase
Ligase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processhistidyl-tRNA aminoacylation

Inferred from electronic annotation. Source: InterPro

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

histidine-tRNA ligase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 422422Histidine--tRNA ligase HAMAP MF_00127
PRO_1000016307

Sequences

Sequence LengthMass (Da)Tools
Q0VNE1 [UniParc].

Last modified September 5, 2006. Version 1.
Checksum: 6A2B20E795997A88

FASTA42246,386
        10         20         30         40         50         60 
MSKKITSIRG MNDILPEQTG LWQWLEAKVG AVLASYGYQE IRMPIVEQTD LFKRSIGEVT 

        70         80         90        100        110        120 
DIVEKEMYTF DDRNGDSLTL RPEGTASCVR ACEQHGLLYN QTQRLWYAGP MFRHERPQAG 

       130        140        150        160        170        180 
RYRQFHQIGV ETFGMTGPDI DAEVILLTAR LWKALGLEDK VVLELNSLGD SADRARYRDA 

       190        200        210        220        230        240 
LVDYLKAHFD DLDGDSQKRL ERSPLRVLDS KDTGTREVLK GAPQLADYLN DEAVAHFEGL 

       250        260        270        280        290        300 
KALLDASGIA YKVNPYLVRG LDYYGKTVFE WVTDALGAQG TVCAGGRYDG LVEQLGGKPT 

       310        320        330        340        350        360 
PAVGFAMGIE RLILLIEQER PELSAPVDVY VMAMGDVLAP TMALSEHLRD ALPGRAIQLH 

       370        380        390        400        410        420 
CGGGSFKSQM KKADRSGAAV GLIMGEDELA SGVVTVKPLR GQGEQVQVAQ GDVANAVTSF 


LE

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AM286690 Genomic DNA. Translation: CAL17307.1.
RefSeqYP_693579.1. NC_008260.1.

3D structure databases

ProteinModelPortalQ0VNE1.
SMRQ0VNE1. Positions 5-421.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ0VNE1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4211474.
GenomeReviewsGene locus ABO_1859 in contig AM286690_GR.
KEGGabo:ABO_1859.
NMPDRfig|393595.12.peg.1864.
PATRIC20841553. VBIAlcBor124741_1951.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0124.
HOGENOMHBG616575.
OMAVFEWVTT.
PhylomeDBQ0VNE1.

Enzyme and pathway databases

BioCycABOR393595:ABO_1859-MONOMER.

Family and domain databases

HAMAPMF_00127. His_tRNA_synth.
[Tree]
InterProIPR002314. aa-tRNA-synt_IIb_cons-dom.
IPR006195. aa-tRNA-synth_II.
IPR004154. Anticodon-bd.
IPR015807. His-tRNA-synth_IIa_subgr.
IPR004516. His-tRNA_synth_IIA.
[Graphical view]
Gene3DG3DSA:3.40.50.800. Anticodon_bd. 1 hit.
KOK01892.
PANTHERPTHR11476. His-tRNA_synth. 1 hit.
PfamPF03129. HGTP_anticodon. 1 hit.
PF00587. tRNA-synt_2b. 1 hit.
[Graphical view]
PIRSFPIRSF001549. His-tRNA_synth. 1 hit.
SUPFAMSSF52954. Anticodon_bd. 1 hit.
TIGRFAMsTIGR00442. HisS. 1 hit.
PROSITEPS50862. AA_TRNA_LIGASE_II. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSYH_ALCBS
AccessionPrimary (citable) accession number: Q0VNE1
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: September 5, 2006
Last modified: January 25, 2012
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Aminoacyl-tRNA synthetases

List of aminoacyl-tRNA synthetase entries

SIMILARITY comments

Index of protein domains and families

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