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Q0VN53

- SYL_ALCBS

UniProt

Q0VN53 - SYL_ALCBS

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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Alcanivorax borkumensis (strain SK2 / ATCC 700651 / DSM 11573)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei577 – 5771ATPUniRule annotation

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciABOR393595:GHRI-1991-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:ABO_1947
OrganismiAlcanivorax borkumensis (strain SK2 / ATCC 700651 / DSM 11573)
Taxonomic identifieri393595 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaOceanospirillalesAlcanivoracaceaeAlcanivorax
ProteomesiUP000008871: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 815815Leucine--tRNA ligasePRO_0000334726Add
BLAST

Proteomic databases

PRIDEiQ0VN53.

Interactioni

Protein-protein interaction databases

STRINGi393595.ABO_1947.

Structurei

3D structure databases

ProteinModelPortaliQ0VN53.
SMRiQ0VN53. Positions 228-412.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi42 – 5211"HIGH" regionAdd
BLAST
Motifi574 – 5785"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q0VN53-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDVQYRPDQI EAQAQQYWDD NQSFKVTEDA SKEKFYCLSM FPYPSGRLHM
60 70 80 90 100
GHVRNYSIGD VVSRYQRMLG KNVLQPMGWD AFGLPAENAA IKNKVAPAKW
110 120 130 140 150
TFENIDYMRG QLQRLGFGYD WGRELATCTP EYYRWEQWFF TKLYEKGLVY
160 170 180 190 200
RKMSTVNWDP VDQTVLANEQ VIDGRGWRSG ALVEQKEIPQ WFIKITDYAD
210 220 230 240 250
ELLNDLDQLD GWPEQVKTMQ RNWIGRSEGV ELDFPIEGEE SLRVYTTRPD
260 270 280 290 300
TLMGVSYVAV AAGHPLAQKA AAANHEVADF IKECQNTKTA EADMATMEKK
310 320 330 340 350
GIYTGLTATH PISGEAVPVW IANFVLMGYG TGAVMAVPAH DQRDFEFAQK
360 370 380 390 400
YGLPINQVIE PANGEPIDLA LEAFTGKGTL IHSGEFDGLS SAEAFNAIAN
410 420 430 440 450
WLSERSLGEK KVNYRLRDWG VSRQRYWGTP IPMVETEDGT LHPTPEDQLP
460 470 480 490 500
VALPTDVEMD GVTSPIKADP EWAKTTFNGQ PALRETDTFD TFMESSWYYA
510 520 530 540 550
RYCSPQSDTA MLDPAATNYW LPVDQYIGGI EHAILHLLYS RFFHKLLRDT
560 570 580 590 600
GLVNCDEPFK QLLCQGMVLK DGAKMSKSKG NTVDPQQMIE EYGADTVRLF
610 620 630 640 650
MMFAAPPEQS LEWNDAGVEG AFRFIKRLWR LVAEHVEAGN TGTLDVNALD
660 670 680 690 700
DAGKALRRKT HETIQKVSDD YGRRNTFNTA IAAVMELINE VSKFDAATDN
710 720 730 740 750
ALAVKQEALE AAVLLLAPII PHAGHSLWQA LGHDEAVIDA SWPSVDESAL
760 770 780 790 800
VKDSIELVVQ VNGKVRAKLN VPANADKASV ESLAMDEPNV KKFTEGKTVR
810
KVIVVPGKLV NIVAN
Length:815
Mass (Da):91,315
Last modified:May 20, 2008 - v2
Checksum:i4B1E6B8ECD966DBA
GO

Sequence cautioni

The sequence CAL17395.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM286690 Genomic DNA. Translation: CAL17395.1. Different initiation.
RefSeqiYP_693667.1. NC_008260.1.

Genome annotation databases

EnsemblBacteriaiCAL17395; CAL17395; ABO_1947.
GeneIDi4211542.
KEGGiabo:ABO_1947.
PATRICi20841731. VBIAlcBor124741_2039.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM286690 Genomic DNA. Translation: CAL17395.1 . Different initiation.
RefSeqi YP_693667.1. NC_008260.1.

3D structure databases

ProteinModelPortali Q0VN53.
SMRi Q0VN53. Positions 228-412.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 393595.ABO_1947.

Proteomic databases

PRIDEi Q0VN53.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAL17395 ; CAL17395 ; ABO_1947 .
GeneIDi 4211542.
KEGGi abo:ABO_1947.
PATRICi 20841731. VBIAlcBor124741_2039.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200747.
KOi K01869.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci ABOR393595:GHRI-1991-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SK2 / ATCC 700651 / DSM 11573.

Entry informationi

Entry nameiSYL_ALCBS
AccessioniPrimary (citable) accession number: Q0VN53
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: May 20, 2008
Last modified: October 29, 2014
This is version 66 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3