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Q0VN49 (PROA_ALCBS) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 46. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Gamma-glutamyl phosphate reductase
Short name=GPR
EC=1.2.1.41
Alternative name(s):
Glutamate-5-semialdehyde dehydrogenase
Glutamyl-gamma-semialdehyde dehydrogenase
Short name=GSA dehydrogenase
Gene names
Name:proA
Ordered Locus Names:ABO_1951
OrganismAlcanivorax borkumensis (strain SK2 / ATCC 700651 / DSM 11573) [Complete proteome] [HAMAP]
Taxonomic identifier393595 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Oceanospirillales › Alcanivoracaceae › Alcanivorax

Protein attributes

Sequence length423 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the NADPH dependent reduction of L-gamma-glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. HAMAP MF_00412

Catalytic activity

L-glutamate 5-semialdehyde + phosphate + NADP+ = L-glutamyl 5-phosphate + NADPH. HAMAP MF_00412

Pathway

Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-glutamate: step 2/2. HAMAP MF_00412

Subcellular location

Cytoplasm By similarity HAMAP MF_00412.

Sequence similarities

Belongs to the gamma-glutamyl phosphate reductase family.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Proline biosynthesis
   Cellular componentCytoplasm
   LigandNADP
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processproline biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionNADP binding

Inferred from electronic annotation. Source: InterPro

glutamate-5-semialdehyde dehydrogenase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 423423Gamma-glutamyl phosphate reductase HAMAP MF_00412
PRO_0000252562

Sequences

Sequence LengthMass (Da)Tools
Q0VN49 [UniParc].

Last modified September 5, 2006. Version 1.
Checksum: BEFF462473B00B92

FASTA42345,299
        10         20         30         40         50         60 
MDIQQYMQRL GEQARQASRA MARASSSDKD KALAAIAGAL RSHRNAILQA NQQDLDAGRN 

        70         80         90        100        110        120 
NGLDAALLDR LELTPDRFDG MVEGLEQIIG LADPIGVITD LAYRPSGIQV GKMRVPLGVI 

       130        140        150        160        170        180 
GIIYESRPNV TVDAAALCLK SGNAAILRGG SEAINANQAI AECIREGLRE AGLPDTAVQV 

       190        200        210        220        230        240 
VETTDRAAVG ELISHPEFVD VIVPRGGKGL IERISNDARV PVIKHLDGNC HTYIDGQANI 

       250        260        270        280        290        300 
AKAISVAYNA KTQRYGTCNT TETLLVANAI APQVLPELAG KYQQAGVELR GCDKARRLLT 

       310        320        330        340        350        360 
EAGITGMVEA SNSDWEEEFL APVLAVKIVD GINDAIEHIN RYSSGHTEAI ITENYTLARR 

       370        380        390        400        410        420 
FLTEVDSSSV MVNASTRFAD GFEYGLGAEI GISTDKIHAR GPVGLEGLTS QKWVVLGDGH 


IRL

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AM286690 Genomic DNA. Translation: CAL17399.1.
RefSeqYP_693671.1. NC_008260.1.

3D structure databases

ProteinModelPortalQ0VN49.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ0VN49.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4211219.
GenomeReviewsGene locus ABO_1951 in contig AM286690_GR.
KEGGabo:ABO_1951.
NMPDRfig|393595.12.peg.1952.
PATRIC20841739. VBIAlcBor124741_2043.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0014.
HOGENOMHBG318080.
OMAQYPAACN.
PhylomeDBQ0VN49.

Enzyme and pathway databases

BioCycABOR393595:ABO_1951-MONOMER.

Family and domain databases

HAMAPMF_00412. ProA.
[Tree]
InterProIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR000965. G-glutamylP_reductase.
IPR020593. G-glutamylP_reductase_CS.
IPR012134. Glu-5-SA_DH.
[Graphical view]
Gene3DG3DSA:3.40.309.10. Aldehyde_dehydrogenase_C. 1 hit.
G3DSA:3.40.605.10. Aldehyde_dehydrogenase_N. 2 hits.
KOK00147.
PANTHERPTHR11063:SF1. GSA_DH. 1 hit.
PfamPF00171. Aldedh. 2 hits.
[Graphical view]
PIRSFPIRSF000151. GPR. 1 hit.
SUPFAMSSF53720. Aldehyde_DH/Histidinol_DH. 1 hit.
TIGRFAMsTIGR00407. ProA. 1 hit.
PROSITEPS01223. PROA. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePROA_ALCBS
AccessionPrimary (citable) accession number: Q0VN49
Entry history
Integrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: September 5, 2006
Last modified: January 25, 2012
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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