ID   PUR9_ALCBS              Reviewed;         525 AA.
AC   Q0VMY5;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-SEP-2006, sequence version 1.
DT   16-JUN-2009, entry version 25.
DE   RecName: Full=Bifunctional purine biosynthesis protein purH;
DE   Includes:
DE     RecName: Full=Phosphoribosylaminoimidazolecarboxamide formyltransferase;
DE              EC=2.1.2.3;
DE     AltName: Full=AICAR transformylase;
DE   Includes:
DE     RecName: Full=IMP cyclohydrolase;
DE              EC=3.5.4.10;
DE     AltName: Full=Inosinicase;
DE     AltName: Full=IMP synthetase;
DE     AltName: Full=ATIC;
GN   Name=purH; OrderedLocusNames=ABO_2015;
OS   Alcanivorax borkumensis (strain SK2 / ATCC 700651 / DSM 11573).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Oceanospirillales;
OC   Alcanivoracaceae; Alcanivorax.
OX   NCBI_TaxID=393595;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16878126; DOI=10.1038/nbt1232;
RA   Schneiker S., Martins dos Santos V.A.P., Bartels D., Bekel T.,
RA   Brecht M., Buhrmester J., Chernikova T.N., Denaro R., Ferrer M.,
RA   Gertler C., Goesmann A., Golyshina O.V., Kaminski F., Khachane A.N.,
RA   Lang S., Linke B., McHardy A.C., Meyer F., Nechitaylo T., Puehler A.,
RA   Regenhardt D., Rupp O., Sabirova J.S., Selbitschka W., Yakimov M.M.,
RA   Timmis K.N., Vorhoelter F.-J., Weidner S., Kaiser O., Golyshin P.N.;
RT   "Genome sequence of the ubiquitous hydrocarbon-degrading marine
RT   bacterium Alcanivorax borkumensis.";
RL   Nat. Biotechnol. 24:997-1004(2006).
CC   -!- CATALYTIC ACTIVITY: 10-formyltetrahydrofolate + 5-amino-1-(5-
CC       phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-
CC       formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.
CC   -!- CATALYTIC ACTIVITY: IMP + H(2)O = 5-formamido-1-(5-phospho-D-
CC       ribosyl)imidazole-4-carboxamide.
CC   -!- PATHWAY: Purine metabolism; IMP biosynthesis via de novo pathway;
CC       5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-
CC       amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide (10-formyl
CC       THF route): step 1/1.
CC   -!- PATHWAY: Purine metabolism; IMP biosynthesis via de novo pathway;
CC       IMP from 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-
CC       carboxamide: step 1/1.
CC   -!- DOMAIN: The IMP cyclohydrolase activity resides in the N-terminal
CC       region (By similarity).
CC   -!- SIMILARITY: Belongs to the purH family.
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DR   EMBL; AM286690; CAL17463.1; -; Genomic_DNA.
DR   RefSeq; YP_693735.1; -.
DR   GeneID; 4211146; -.
DR   GenomeReviews; AM286690_GR; ABO_2015.
DR   KEGG; abo:ABO_2015; -.
DR   NMPDR; fig|393595.12.peg.2017; -.
DR   HOGENOM; Q0VMY5; -.
DR   OMA; Q0VMY5; VVKHVKS.
DR   BioCyc; ABOR393595:ABO_2015-MON; -.
DR   GO; GO:0003937; F:IMP cyclohydrolase activity; IEA:HAMAP.
DR   GO; GO:0004643; F:phosphoribosylaminoimidazolecarboxamide for...; IEA:HAMAP.
DR   GO; GO:0006188; P:IMP biosynthetic process; IEA:InterPro.
DR   HAMAP; MF_00139; -; 1.
DR   InterPro; IPR002695; AICARFT_IMPCHas.
DR   InterPro; IPR013982; AICARFT_IMPCHas_formly.
DR   InterPro; IPR011607; MGS.
DR   PANTHER; PTHR11692; AICARFT_IMPCHas; 1.
DR   Pfam; PF01808; AICARFT_IMPCHas; 1.
DR   Pfam; PF02142; MGS; 1.
DR   PIRSF; PIRSF000414; AICARFT_IMPCHas; 1.
DR   SMART; SM00798; AICARFT_IMPCHas; 1.
DR   TIGRFAMs; TIGR00355; purH; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Hydrolase; Multifunctional enzyme;
KW   Purine biosynthesis; Transferase.
FT   CHAIN         1    525       Bifunctional purine biosynthesis protein
FT                                purH.
FT                                /FTId=PRO_1000057892.
SQ   SEQUENCE   525 AA;  56122 MW;  4C40FF4E3C0E576D CRC64;
     MSNVERALIS VSDKTGIVEF AQALADKGVE LLSTGGTFKK LQEAGIAVRE VSDYTGFPEM
     MAGRVKTLHP KVHGGILGRR GQDEQVMADN DISPIDLVVV NLYPFEATVA NPDCSLEDAI
     ENIDIGGPTM VRSAAKNNAS VGIVTDAADY QRVLDDMAAN NGALSDDLRF DLAIKAFEHT
     AAYDSAIANY FGKKVEGQDG MSNLDFPRTI NLNFEKTQNM RYGENPHQKA AFYTERNPAP
     ASIATAKQLQ GKELSYNNIA DTDAALECVK GFTKPACVIV KHANPCGVAV SLDGITTAYD
     LAFATDTESA FGGIIAFNRK LDAATAQAIV DRQFVEVIIA PSATEEALAI TAAKKNVRVL
     VCGEMEGVAA SGLDYKRVNG GLLVQDRDLG MITEGELKVV TKRAPTEAEM HDLIFAWKVA
     KFVKSNAIVY AKDRQTVGVG AGQMSRVNSA RIAAIKAEHA GLQVKGSVMA SDAFFPFRDG
     IDNAAKVGIS CVIQPGGSIR DEEVIAAADE AGMAMVFTGM RHFRH
//