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Q0VMY5

- PUR9_ALCBS

UniProt

Q0VMY5 - PUR9_ALCBS

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Protein
Bifunctional purine biosynthesis protein PurH
Gene
purH, ABO_2015
Organism
Alcanivorax borkumensis (strain SK2 / ATCC 700651 / DSM 11573)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation
IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. IMP cyclohydrolase activity Source: UniProtKB-HAMAP
  2. phosphoribosylaminoimidazolecarboxamide formyltransferase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Transferase

Keywords - Biological processi

Purine biosynthesis

Enzyme and pathway databases

BioCyciABOR393595:GHRI-2062-MONOMER.
UniPathwayiUPA00074; UER00133.
UPA00074; UER00135.

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional purine biosynthesis protein PurH
Including the following 2 domains:
Phosphoribosylaminoimidazolecarboxamide formyltransferase (EC:2.1.2.3)
Alternative name(s):
AICAR transformylase
IMP cyclohydrolase (EC:3.5.4.10)
Alternative name(s):
ATIC
IMP synthase
Inosinicase
Gene namesi
Name:purH
Ordered Locus Names:ABO_2015
OrganismiAlcanivorax borkumensis (strain SK2 / ATCC 700651 / DSM 11573)
Taxonomic identifieri393595 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaOceanospirillalesAlcanivoracaceaeAlcanivorax
ProteomesiUP000008871: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 525525Bifunctional purine biosynthesis protein PurHUniRule annotation
PRO_1000057892Add
BLAST

Proteomic databases

PRIDEiQ0VMY5.

Interactioni

Protein-protein interaction databases

STRINGi393595.ABO_2015.

Structurei

3D structure databases

ProteinModelPortaliQ0VMY5.

Family & Domainsi

Domaini

The IMP cyclohydrolase activity resides in the N-terminal region By similarity.UniRule annotation

Sequence similaritiesi

Belongs to the PurH family.

Phylogenomic databases

eggNOGiCOG0138.
HOGENOMiHOG000230372.
KOiK00602.
OMAiRAFKTDP.
OrthoDBiEOG6QCDFF.

Family and domain databases

Gene3Di3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPiMF_00139. PurH.
InterProiIPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view]
PANTHERiPTHR11692. PTHR11692. 1 hit.
PfamiPF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view]
PIRSFiPIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTiSM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view]
SUPFAMiSSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsiTIGR00355. purH. 1 hit.

Sequencei

Sequence statusi: Complete.

Q0VMY5-1 [UniParc]FASTAAdd to Basket

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MSNVERALIS VSDKTGIVEF AQALADKGVE LLSTGGTFKK LQEAGIAVRE    50
VSDYTGFPEM MAGRVKTLHP KVHGGILGRR GQDEQVMADN DISPIDLVVV 100
NLYPFEATVA NPDCSLEDAI ENIDIGGPTM VRSAAKNNAS VGIVTDAADY 150
QRVLDDMAAN NGALSDDLRF DLAIKAFEHT AAYDSAIANY FGKKVEGQDG 200
MSNLDFPRTI NLNFEKTQNM RYGENPHQKA AFYTERNPAP ASIATAKQLQ 250
GKELSYNNIA DTDAALECVK GFTKPACVIV KHANPCGVAV SLDGITTAYD 300
LAFATDTESA FGGIIAFNRK LDAATAQAIV DRQFVEVIIA PSATEEALAI 350
TAAKKNVRVL VCGEMEGVAA SGLDYKRVNG GLLVQDRDLG MITEGELKVV 400
TKRAPTEAEM HDLIFAWKVA KFVKSNAIVY AKDRQTVGVG AGQMSRVNSA 450
RIAAIKAEHA GLQVKGSVMA SDAFFPFRDG IDNAAKVGIS CVIQPGGSIR 500
DEEVIAAADE AGMAMVFTGM RHFRH 525
Length:525
Mass (Da):56,122
Last modified:September 5, 2006 - v1
Checksum:i4C40FF4E3C0E576D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM286690 Genomic DNA. Translation: CAL17463.1.
RefSeqiYP_693735.1. NC_008260.1.

Genome annotation databases

EnsemblBacteriaiCAL17463; CAL17463; ABO_2015.
GeneIDi4211146.
KEGGiabo:ABO_2015.
PATRICi20841879. VBIAlcBor124741_2110.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM286690 Genomic DNA. Translation: CAL17463.1 .
RefSeqi YP_693735.1. NC_008260.1.

3D structure databases

ProteinModelPortali Q0VMY5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 393595.ABO_2015.

Proteomic databases

PRIDEi Q0VMY5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAL17463 ; CAL17463 ; ABO_2015 .
GeneIDi 4211146.
KEGGi abo:ABO_2015.
PATRICi 20841879. VBIAlcBor124741_2110.

Phylogenomic databases

eggNOGi COG0138.
HOGENOMi HOG000230372.
KOi K00602.
OMAi RAFKTDP.
OrthoDBi EOG6QCDFF.

Enzyme and pathway databases

UniPathwayi UPA00074 ; UER00133 .
UPA00074 ; UER00135 .
BioCyci ABOR393595:GHRI-2062-MONOMER.

Family and domain databases

Gene3Di 3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPi MF_00139. PurH.
InterProi IPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view ]
PANTHERi PTHR11692. PTHR11692. 1 hit.
Pfami PF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view ]
PIRSFi PIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTi SM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view ]
SUPFAMi SSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsi TIGR00355. purH. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SK2 / ATCC 700651 / DSM 11573.

Entry informationi

Entry nameiPUR9_ALCBS
AccessioniPrimary (citable) accession number: Q0VMY5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: September 5, 2006
Last modified: May 14, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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