Reviewed, UniProtKB/Swiss-Prot Q0VMU1 (GCP_ALCBS)

Names and origin

Protein names

Recommended name:
    Probable O-sialoglycoprotein endopeptidase
      Short name=Glycoprotease
    EC=3.4.24.57

Gene names

Name:	gcp
Ordered Locus Names:	ABO_2059

Organism

Alcanivorax borkumensis (strain SK2 / ATCC 700651 / DSM 11573) [Complete proteome] [HAMAP]

Taxonomic identifier

393595 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Oceanospirillales › Alcanivoracaceae › Alcanivorax

Protein attributes

Sequence length	345 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Hydrolysis of O-sialoglycoproteins; cleaves 31-Arg-|-Asp-32 bond in glycophorin A. Does not cleave unglycosylated proteins, desialylated glycoproteins or glycoproteins that are only N-glycosylated. HAMAP MF_01445
Cofactor	Zinc Probable.
Sequence similarities	Belongs to the peptidase M22 family.

Ontologies

Keywords
Ligand	Metal-binding Zinc
Molecular function	Hydrolase Metalloprotease Protease
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	proteolysis Inferred from electronic annotation. Source: InterPro
Molecular function	metalloendopeptidase activity Inferred from electronic annotation. Source: HAMAP zinc ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 345	345	Probable O-sialoglycoprotein endopeptidase HAMAP MF_01445		PRO_0000303250
Sites
	Metal binding	111	1	Zinc Potential
	Metal binding	115	1	Zinc Potential

Sequences

	Sequence		Length	Mass (Da)
	Q0VMU1-1 [UniParc]. Last modified September 5, 2006. Version 1. Checksum: FD6E28D68B5ECCF3	FASTA	345	36,828
	10 20 30 40 50 60 MRVLGIESSC DETGVAIYDT EQGLLGQALY SQVEMHARYG GVVPELASRD HVQRVLPLIR 70 80 90 100 110 120 EVMTEANTQP QQLDGVAFTA GPGLAGALLV GAGVARSLAF GWNLPAVAVH HMEGHLLAPL 130 140 150 160 170 180 LEPNAPAFPF VALLVSGGHT LLLDAKALGE YEILGESVDD AAGEAFDKAA KMMGLGYPGG 190 200 210 220 230 240 PRVATLAQQG TAGRFRFPRP MTDRPGLDMS FSGLKTFTLN TINDLGGKEA LSEQDRADIA 250 260 270 280 290 300 RAFEEAAVDT LVIKCRRAVE QTGHKRLVMA GGVSANQSLR AKLAEQMKKR GVDVYYPAPQ 310 320 330 340 YCTDNGAMIA FAGALRLQAG ERAELPIKIR PRWPLTELAK LQGAD

References

[1]

"Genome sequence of the ubiquitous hydrocarbon-degrading marine bacterium Alcanivorax borkumensis." Schneiker S., Martins dos Santos V.A.P., Bartels D., Bekel T., Brecht M., Buhrmester J., Chernikova T.N., Denaro R., Ferrer M., Gertler C., Goesmann A., Golyshina O.V., Kaminski F., Khachane A.N., Lang S., Linke B., McHardy A.C., Meyer F. , Nechitaylo T., Puehler A., Regenhardt D., Rupp O., Sabirova J.S., Selbitschka W., Yakimov M.M., Timmis K.N., Vorhoelter F.-J., Weidner S., Kaiser O., Golyshin P.N. Nat. Biotechnol. 24:997-1004(2006) [PubMed: 16878126] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AM286690 Genomic DNA. Translation: CAL17507.1.
RefSeq	YP_693779.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q0VMU1.
Protein family/group databases
MEROPS	M22.001.
Genome annotation databases
GeneID	4211688.
GenomeReviews	Gene locus ABO_2059 in contig AM286690_GR.
KEGG	abo:ABO_2059.
NMPDR	fig|393595.12.peg.2061.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q0VMU1.
OMA	CKRALKQ.
Enzyme and pathway databases
BioCyc	ABOR393595:ABO_2059-MON.
Family and domain databases
HAMAP	MF_01445. [Tree]
InterPro	IPR009180. Pept_M22_Osialgl. IPR000905. Peptidase_M22. IPR017860. Peptidase_M22_CS. IPR017861. Peptidase_M22_subgr. [Graphical view]
PANTHER	PTHR11735. Pept_M22_Osialgl. 1 hit.
Pfam	PF00814. Peptidase_M22. 1 hit. [Graphical view]
PRINTS	PR00789. OSIALOPTASE.
ProDom	PD002367. Peptidase_M22. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR00329. gcp. 1 hit.
PROSITE	PS01016. GLYCOPROTEASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GCP_ALCBS

Accession

Primary (citable) accession number: Q0VMU1

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 11, 2007
Last sequence update:	September 5, 2006
Last modified:	November 3, 2009
This is version 28 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)