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Q0VML6

- HIS3_ALCBS

UniProt

Q0VML6 - HIS3_ALCBS

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Protein
Phosphoribosyl-AMP cyclohydrolase
Gene
hisI, ABO_2134
Organism
Alcanivorax borkumensis (strain SK2 / ATCC 700651 / DSM 11573)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP By similarity.

Catalytic activityi

1-(5-phospho-beta-D-ribosyl)-AMP + H2O = 1-(5-phospho-beta-D-ribosyl)-5-((5-phospho-beta-D-ribosylamino)methylideneamino)imidazole-4-carboxamide.UniRule annotation

Cofactori

Binds 1 magnesium ion per subunit By similarity.
Binds 1 zinc ion per subunit By similarity.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi92 – 921Magnesium By similarity
Metal bindingi93 – 931Zinc; shared with dimeric partner By similarity
Metal bindingi94 – 941Magnesium By similarity
Metal bindingi96 – 961Magnesium By similarity
Metal bindingi109 – 1091Zinc; shared with dimeric partner By similarity
Metal bindingi116 – 1161Zinc; shared with dimeric partner By similarity

GO - Molecular functioni

  1. phosphoribosyl-AMP cyclohydrolase activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

  1. histidine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Amino-acid biosynthesis, Histidine biosynthesis

Keywords - Ligandi

Magnesium, Metal-binding, Zinc

Enzyme and pathway databases

BioCyciABOR393595:GHRI-2182-MONOMER.
UniPathwayiUPA00031; UER00008.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoribosyl-AMP cyclohydrolase (EC:3.5.4.19)
Short name:
PRA-CH
Gene namesi
Name:hisI
Ordered Locus Names:ABO_2134
OrganismiAlcanivorax borkumensis (strain SK2 / ATCC 700651 / DSM 11573)
Taxonomic identifieri393595 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaOceanospirillalesAlcanivoracaceaeAlcanivorax
ProteomesiUP000008871: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 142142Phosphoribosyl-AMP cyclohydrolaseUniRule annotation
PRO_0000319680Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.

Protein-protein interaction databases

STRINGi393595.ABO_2134.

Structurei

3D structure databases

ProteinModelPortaliQ0VML6.
SMRiQ0VML6. Positions 22-136.

Family & Domainsi

Sequence similaritiesi

Belongs to the PRA-CH family.

Phylogenomic databases

eggNOGiCOG0139.
HOGENOMiHOG000277504.
KOiK01496.
OMAiDITTIMT.
OrthoDBiEOG6PGKB6.

Family and domain databases

HAMAPiMF_01021. HisI.
InterProiIPR026660. PRA-CH.
IPR002496. PRib_AMP_CycHydrolase_dom.
[Graphical view]
PfamiPF01502. PRA-CH. 1 hit.
[Graphical view]
ProDomiPD002610. PRA_CycHdrlase. 1 hit.
[Graphical view] [Entries sharing at least one domain]

Sequencei

Sequence statusi: Complete.

Q0VML6-1 [UniParc]FASTAAdd to Basket

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MFKHNEQQPE GFQISLKEAL DNLAFNDAGL VAAIAQQHDS GEVLMMAWMN    50
REAIEETLAT GRVCYFSRSR GKLWRKGESS GQVQTLKELR IDCDGDALLV 100
KVDQTGSACH TGRRDCFYWK ADANNVTIDK APIKDPKELY GK 142
Length:142
Mass (Da):15,938
Last modified:September 5, 2006 - v1
Checksum:i1AB3214F6B1C4E9F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM286690 Genomic DNA. Translation: CAL17582.1.
RefSeqiWP_011589412.1. NC_008260.1.
YP_693854.1. NC_008260.1.

Genome annotation databases

EnsemblBacteriaiCAL17582; CAL17582; ABO_2134.
GeneIDi4211473.
KEGGiabo:ABO_2134.
PATRICi20842127. VBIAlcBor124741_2233.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM286690 Genomic DNA. Translation: CAL17582.1 .
RefSeqi WP_011589412.1. NC_008260.1.
YP_693854.1. NC_008260.1.

3D structure databases

ProteinModelPortali Q0VML6.
SMRi Q0VML6. Positions 22-136.
ModBasei Search...

Protein-protein interaction databases

STRINGi 393595.ABO_2134.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAL17582 ; CAL17582 ; ABO_2134 .
GeneIDi 4211473.
KEGGi abo:ABO_2134.
PATRICi 20842127. VBIAlcBor124741_2233.

Phylogenomic databases

eggNOGi COG0139.
HOGENOMi HOG000277504.
KOi K01496.
OMAi DITTIMT.
OrthoDBi EOG6PGKB6.

Enzyme and pathway databases

UniPathwayi UPA00031 ; UER00008 .
BioCyci ABOR393595:GHRI-2182-MONOMER.

Family and domain databases

HAMAPi MF_01021. HisI.
InterProi IPR026660. PRA-CH.
IPR002496. PRib_AMP_CycHydrolase_dom.
[Graphical view ]
Pfami PF01502. PRA-CH. 1 hit.
[Graphical view ]
ProDomi PD002610. PRA_CycHdrlase. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SK2 / ATCC 700651 / DSM 11573.

Entry informationi

Entry nameiHIS3_ALCBS
AccessioniPrimary (citable) accession number: Q0VML6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: September 5, 2006
Last modified: September 3, 2014
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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