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Q0VML6 (HIS3_ALCBS) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 52. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Phosphoribosyl-AMP cyclohydrolase

Short name=PRA-CH
EC=3.5.4.19
Gene names
Name:hisI
Ordered Locus Names:ABO_2134
OrganismAlcanivorax borkumensis (strain SK2 / ATCC 700651 / DSM 11573) [Complete proteome] [HAMAP]
Taxonomic identifier393595 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaOceanospirillalesAlcanivoracaceaeAlcanivorax

Protein attributes

Sequence length142 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

1-(5-phospho-beta-D-ribosyl)-AMP + H2O = 1-(5-phospho-beta-D-ribosyl)-5-((5-phospho-beta-D-ribosylamino)methylideneamino)imidazole-4-carboxamide. HAMAP-Rule MF_01021

Pathway

Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 3/9. HAMAP-Rule MF_01021

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_01021.

Sequence similarities

Belongs to the PRA-CH family.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Histidine biosynthesis
   Cellular componentCytoplasm
   Molecular functionHydrolase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processhistidine biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionphosphoribosyl-AMP cyclohydrolase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 142142Phosphoribosyl-AMP cyclohydrolase HAMAP-Rule MF_01021
PRO_0000319680

Sequences

Sequence LengthMass (Da)Tools
Q0VML6 [UniParc].

Last modified September 5, 2006. Version 1.
Checksum: 1AB3214F6B1C4E9F

FASTA14215,938
        10         20         30         40         50         60 
MFKHNEQQPE GFQISLKEAL DNLAFNDAGL VAAIAQQHDS GEVLMMAWMN REAIEETLAT 

        70         80         90        100        110        120 
GRVCYFSRSR GKLWRKGESS GQVQTLKELR IDCDGDALLV KVDQTGSACH TGRRDCFYWK 

       130        140 
ADANNVTIDK APIKDPKELY GK 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AM286690 Genomic DNA. Translation: CAL17582.1.
RefSeqYP_693854.1. NC_008260.1.

3D structure databases

ProteinModelPortalQ0VML6.
SMRQ0VML6. Positions 22-136.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING393595.ABO_2134.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAL17582; CAL17582; ABO_2134.
GeneID4211473.
KEGGabo:ABO_2134.
PATRIC20842127. VBIAlcBor124741_2233.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0139.
HOGENOMHOG000277504.
KOK01496.
OMACCHTGRR.
OrthoDBEOG6PGKB6.
ProtClustDBPRK00051.

Enzyme and pathway databases

BioCycABOR393595:GHRI-2182-MONOMER.
UniPathwayUPA00031; UER00008.

Family and domain databases

HAMAPMF_01021. HisI.
InterProIPR026660. PRA-CH.
IPR002496. PRib_AMP_CycHydrolase_dom.
[Graphical view]
PfamPF01502. PRA-CH. 1 hit.
[Graphical view]
ProDomPD002610. PRA_CycHdrlase. 1 hit.
[Graphical view] [Entries sharing at least one domain]
ProtoNetSearch...

Entry information

Entry nameHIS3_ALCBS
AccessionPrimary (citable) accession number: Q0VML6
Entry history
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: September 5, 2006
Last modified: February 19, 2014
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways