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Q0VML6

- HIS3_ALCBS

UniProt

Q0VML6 - HIS3_ALCBS

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Protein

Phosphoribosyl-AMP cyclohydrolase

Gene

hisI

Organism
Alcanivorax borkumensis (strain SK2 / ATCC 700651 / DSM 11573)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP.UniRule annotation

Catalytic activityi

1-(5-phospho-beta-D-ribosyl)-AMP + H2O = 1-(5-phospho-beta-D-ribosyl)-5-((5-phospho-beta-D-ribosylamino)methylideneamino)imidazole-4-carboxamide.UniRule annotation

Cofactori

Binds 1 magnesium ion per subunit.UniRule annotation
Binds 1 zinc ion per subunit.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi92 – 921MagnesiumUniRule annotation
Metal bindingi93 – 931Zinc; shared with dimeric partnerUniRule annotation
Metal bindingi94 – 941MagnesiumUniRule annotation
Metal bindingi96 – 961MagnesiumUniRule annotation
Metal bindingi109 – 1091Zinc; shared with dimeric partnerUniRule annotation
Metal bindingi116 – 1161Zinc; shared with dimeric partnerUniRule annotation

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. phosphoribosyl-AMP cyclohydrolase activity Source: UniProtKB-EC

GO - Biological processi

  1. histidine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Amino-acid biosynthesis, Histidine biosynthesis

Keywords - Ligandi

Magnesium, Metal-binding, Zinc

Enzyme and pathway databases

BioCyciABOR393595:GHRI-2182-MONOMER.
UniPathwayiUPA00031; UER00008.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoribosyl-AMP cyclohydrolaseUniRule annotation (EC:3.5.4.19UniRule annotation)
Short name:
PRA-CHUniRule annotation
Gene namesi
Name:hisIUniRule annotation
Ordered Locus Names:ABO_2134
OrganismiAlcanivorax borkumensis (strain SK2 / ATCC 700651 / DSM 11573)
Taxonomic identifieri393595 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaOceanospirillalesAlcanivoracaceaeAlcanivorax
ProteomesiUP000008871: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 142142Phosphoribosyl-AMP cyclohydrolasePRO_0000319680Add
BLAST

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi393595.ABO_2134.

Structurei

3D structure databases

ProteinModelPortaliQ0VML6.
SMRiQ0VML6. Positions 22-136.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PRA-CH family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0139.
HOGENOMiHOG000277504.
KOiK01496.
OMAiDITTIMT.
OrthoDBiEOG6PGKB6.

Family and domain databases

HAMAPiMF_01021. HisI.
InterProiIPR026660. PRA-CH.
IPR002496. PRib_AMP_CycHydrolase_dom.
[Graphical view]
PfamiPF01502. PRA-CH. 1 hit.
[Graphical view]
ProDomiPD002610. PRA_CycHdrlase. 1 hit.
[Graphical view] [Entries sharing at least one domain]

Sequencei

Sequence statusi: Complete.

Q0VML6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MFKHNEQQPE GFQISLKEAL DNLAFNDAGL VAAIAQQHDS GEVLMMAWMN
60 70 80 90 100
REAIEETLAT GRVCYFSRSR GKLWRKGESS GQVQTLKELR IDCDGDALLV
110 120 130 140
KVDQTGSACH TGRRDCFYWK ADANNVTIDK APIKDPKELY GK
Length:142
Mass (Da):15,938
Last modified:September 5, 2006 - v1
Checksum:i1AB3214F6B1C4E9F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM286690 Genomic DNA. Translation: CAL17582.1.
RefSeqiYP_693854.1. NC_008260.1.

Genome annotation databases

EnsemblBacteriaiCAL17582; CAL17582; ABO_2134.
GeneIDi4211473.
KEGGiabo:ABO_2134.
PATRICi20842127. VBIAlcBor124741_2233.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM286690 Genomic DNA. Translation: CAL17582.1 .
RefSeqi YP_693854.1. NC_008260.1.

3D structure databases

ProteinModelPortali Q0VML6.
SMRi Q0VML6. Positions 22-136.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 393595.ABO_2134.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAL17582 ; CAL17582 ; ABO_2134 .
GeneIDi 4211473.
KEGGi abo:ABO_2134.
PATRICi 20842127. VBIAlcBor124741_2233.

Phylogenomic databases

eggNOGi COG0139.
HOGENOMi HOG000277504.
KOi K01496.
OMAi DITTIMT.
OrthoDBi EOG6PGKB6.

Enzyme and pathway databases

UniPathwayi UPA00031 ; UER00008 .
BioCyci ABOR393595:GHRI-2182-MONOMER.

Family and domain databases

HAMAPi MF_01021. HisI.
InterProi IPR026660. PRA-CH.
IPR002496. PRib_AMP_CycHydrolase_dom.
[Graphical view ]
Pfami PF01502. PRA-CH. 1 hit.
[Graphical view ]
ProDomi PD002610. PRA_CycHdrlase. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SK2 / ATCC 700651 / DSM 11573.

Entry informationi

Entry nameiHIS3_ALCBS
AccessioniPrimary (citable) accession number: Q0VML6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: September 5, 2006
Last modified: October 29, 2014
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3