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Q0VMK6 (GCH4_ALCBS) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 49. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
GTP cyclohydrolase FolE2

EC=3.5.4.16
Gene names
Name:folE2
Ordered Locus Names:ABO_2144
OrganismAlcanivorax borkumensis (strain SK2 / ATCC 700651 / DSM 11573) [Complete proteome] [HAMAP]
Taxonomic identifier393595 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaOceanospirillalesAlcanivoracaceaeAlcanivorax

Protein attributes

Sequence length307 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Converts GTP to 7,8-dihydroneopterin triphosphate By similarity. HAMAP-Rule MF_01527

Catalytic activity

GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate. HAMAP-Rule MF_01527

Pathway

Cofactor biosynthesis; 7,8-dihydroneopterin triphosphate biosynthesis; 7,8-dihydroneopterin triphosphate from GTP: step 1/1. HAMAP-Rule MF_01527

Sequence similarities

Belongs to the GTP cyclohydrolase IV family.

Sequence caution

The sequence CAL17592.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Molecular functionHydrolase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_process7,8-dihydroneopterin 3'-triphosphate biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionGTP cyclohydrolase I activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 307307GTP cyclohydrolase FolE2 HAMAP-Rule MF_01527
PRO_0000289471

Sites

Site1521May be catalytically important By similarity

Sequences

Sequence LengthMass (Da)Tools
Q0VMK6 [UniParc].

Last modified May 5, 2009. Version 2.
Checksum: 1ABDF62C95C34D2D

FASTA30734,092
        10         20         30         40         50         60 
MPDVASNSMV DHIHTTLDWV GMSEIHLPAR VSDTLAGERP VSTSIQAYVN LANADAKGIH 

        70         80         90        100        110        120 
MSRLFLMLEE TFGDHSVSAG SIEQLLRNFL QTHEGLSTRG FVQLDFEYSM RRAALKSSYS 

       130        140        150        160        170        180 
GWKSYPVSIK GTLCEDGMRI ELSVEVPYSS TCPCSAALSR QLIQEQFRKD FEESKVDTDA 

       190        200        210        220        230        240 
VLEWLGTEEG ILATPHSQRS IAQVRVLLDH NVGDAFPITA LIDSIEGALK TPVQTAVKRV 

       250        260        270        280        290        300 
DEQEFALLNG QNLMFCEDAA RRLKTALNPQ SCYKDFWLRV NHLESLHAHN AVAIVTKEVE 


GGYLPIP 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AM286690 Genomic DNA. Translation: CAL17592.1. Different initiation.
RefSeqYP_693864.1. NC_008260.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING393595.ABO_2144.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAL17592; CAL17592; ABO_2144.
GeneID4212070.
KEGGabo:ABO_2144.
PATRIC20842149. VBIAlcBor124741_2244.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1469.
HOGENOMHOG000247517.
KOK09007.
OrthoDBEOG6X6RBH.
ProtClustDBPRK13674.

Enzyme and pathway databases

BioCycABOR393595:GHRI-2192-MONOMER.
UniPathwayUPA00848; UER00151.

Family and domain databases

HAMAPMF_01527_B. GTP_cyclohydrol_B.
InterProIPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
[Graphical view]
PfamPF02649. GCHY-1. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGCH4_ALCBS
AccessionPrimary (citable) accession number: Q0VMK6
Entry history
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: May 5, 2009
Last modified: February 19, 2014
This is version 49 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways