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Protein

Malonyl-[acyl-carrier protein] O-methyltransferase

Gene

bioC

Organism
Alcanivorax borkumensis (strain ATCC 700651 / DSM 11573 / NCIMB 13689 / SK2)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl-L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + malonyl-[acyl-carrier protein] = S-adenosyl-L-homocysteine + malonyl-[acyl-carrier protein] methyl ester.UniRule annotation

Pathwayi: biotin biosynthesis

This protein is involved in the pathway biotin biosynthesis, which is part of Cofactor biosynthesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway biotin biosynthesis and in Cofactor biosynthesis.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

Biotin biosynthesis

Keywords - Ligandi

S-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciABOR393595:GHRI-2266-MONOMER.
UniPathwayiUPA00078.

Names & Taxonomyi

Protein namesi
Recommended name:
Malonyl-[acyl-carrier protein] O-methyltransferaseUniRule annotation (EC:2.1.1.197UniRule annotation)
Short name:
Malonyl-ACP O-methyltransferaseUniRule annotation
Alternative name(s):
Biotin synthesis protein BioCUniRule annotation
Gene namesi
Name:bioCUniRule annotation
Ordered Locus Names:ABO_2217
OrganismiAlcanivorax borkumensis (strain ATCC 700651 / DSM 11573 / NCIMB 13689 / SK2)
Taxonomic identifieri393595 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaOceanospirillalesAlcanivoracaceaeAlcanivorax
Proteomesi
  • UP000008871 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 292292Malonyl-[acyl-carrier protein] O-methyltransferasePRO_0000412475Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi393595.ABO_2217.

Structurei

3D structure databases

ProteinModelPortaliQ0VMD3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the methyltransferase superfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG410626R. Bacteria.
COG0500. LUCA.
HOGENOMiHOG000265010.
KOiK02169.
OMAiLVHVNRF.
OrthoDBiPOG091H05JY.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
HAMAPiMF_00835. BioC. 1 hit.
InterProiIPR011814. BioC.
IPR013216. Methyltransf_11.
IPR029063. SAM-dependent_MTases.
[Graphical view]
PfamiPF08241. Methyltransf_11. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR02072. BioC. 1 hit.

Sequencei

Sequence statusi: Complete.

Q0VMD3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYPSCRPRTP LPRPCMTFIA TISWSAEAPV DTPVERSGKA VVSQHFGRAA
60 70 80 90 100
RSYDEHAVLQ LAVGRSLVQR LPEALPINHA LDLGCATAPF ARAQQQALPD
110 120 130 140 150
VQWQAVDLSS AMLAEAAERG RLDETYQPLC ADAENLPLST NSQGLVFSCF
160 170 180 190 200
ALQWCDPQVV MAEINRVLAP GGRLLLAVPL AGSLAELQSS WQRVNHRPHV
210 220 230 240 250
NALPSLADWR SAAFQAGFAD AQLQQQVMVE YYDSVKAIAR RLKATGADHV
260 270 280 290
SGASGLTGKN AWQAMVKEYE ARRTQQGLPL TWNVLFLEAE KS
Length:292
Mass (Da):31,899
Last modified:September 5, 2006 - v1
Checksum:i90389BA9FAB00879
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM286690 Genomic DNA. Translation: CAL17665.1.
RefSeqiWP_011589493.1. NC_008260.1.

Genome annotation databases

EnsemblBacteriaiCAL17665; CAL17665; ABO_2217.
KEGGiabo:ABO_2217.
PATRICi20842303. VBIAlcBor124741_2320.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM286690 Genomic DNA. Translation: CAL17665.1.
RefSeqiWP_011589493.1. NC_008260.1.

3D structure databases

ProteinModelPortaliQ0VMD3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi393595.ABO_2217.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAL17665; CAL17665; ABO_2217.
KEGGiabo:ABO_2217.
PATRICi20842303. VBIAlcBor124741_2320.

Phylogenomic databases

eggNOGiENOG410626R. Bacteria.
COG0500. LUCA.
HOGENOMiHOG000265010.
KOiK02169.
OMAiLVHVNRF.
OrthoDBiPOG091H05JY.

Enzyme and pathway databases

UniPathwayiUPA00078.
BioCyciABOR393595:GHRI-2266-MONOMER.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
HAMAPiMF_00835. BioC. 1 hit.
InterProiIPR011814. BioC.
IPR013216. Methyltransf_11.
IPR029063. SAM-dependent_MTases.
[Graphical view]
PfamiPF08241. Methyltransf_11. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR02072. BioC. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiBIOC_ALCBS
AccessioniPrimary (citable) accession number: Q0VMD3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 21, 2011
Last sequence update: September 5, 2006
Last modified: September 7, 2016
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.