Skip Header

Contribute Send feedback
Read comments (?) or add your own

Q0VMC3 (DCUP_ALCBS) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 43. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Uroporphyrinogen decarboxylase
Short name=UPD
Short name=URO-D
EC=4.1.1.37
Gene names
Name:hemE
Ordered Locus Names:ABO_2227
OrganismAlcanivorax borkumensis (strain SK2 / ATCC 700651 / DSM 11573) [Complete proteome] [HAMAP]
Taxonomic identifier393595 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Oceanospirillales › Alcanivoracaceae › Alcanivorax

Protein attributes

Sequence length353 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III By similarity. HAMAP MF_00218

Catalytic activity

Uroporphyrinogen III = coproporphyrinogen + 4 CO2. HAMAP MF_00218

Pathway

Porphyrin metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 4/4. HAMAP MF_00218

Subunit structure

Homodimer By similarity. HAMAP MF_00218

Subcellular location

Cytoplasm By similarity HAMAP MF_00218.

Sequence similarities

Belongs to the uroporphyrinogen decarboxylase family.

Ontologies

Keywords
   Biological processPorphyrin biosynthesis
   Cellular componentCytoplasm
   Molecular functionDecarboxylase
Lyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processporphyrin-containing compound biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionuroporphyrinogen decarboxylase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 353353Uroporphyrinogen decarboxylase HAMAP MF_00218
PRO_0000325620

Regions

Region29 – 335Substrate binding By similarity

Sites

Binding site791Substrate By similarity
Binding site1561Substrate By similarity
Binding site2111Substrate By similarity
Binding site3291Substrate By similarity
Site791Transition state stabilizer By similarity

Sequences

Sequence LengthMass (Da)Tools
Q0VMC3 [UniParc].

Last modified September 5, 2006. Version 1.
Checksum: 1C23D2AA76CFFD4F

FASTA35338,968
        10         20         30         40         50         60 
MTFAPLQNDR FLRALNRETV DRTPIWMMRQ AGRYLPEYRA AREHAGSFMD LCKNADLACE 

        70         80         90        100        110        120 
VTLQPLERYP LDAAILFSDI LTIPDAMGLG LYFETGEGPK FRKVVRTEAD VAALPIPDAE 

       130        140        150        160        170        180 
SDLGYVMNAV STIRGALNGR VPLIGFSGSP WTLATYMVEG GSSKDFRHLK AMVYSQPELA 

       190        200        210        220        230        240 
HAMLDKLAQS VTGYLNAQIR HGAQAVQIFD TWGGALSAEA YKEFSLRYMQ QIVDGLIRDN 

       250        260        270        280        290        300 
EGRKVPVILF TKNGGLWLES MAATGCDALG LDWTINIGDA RRRVGDKVAL QGNMDPAVLY 

       310        320        330        340        350 
ASPQAIRAEV KRILDDFGDH PGHIFNLGHG ITPQVDPEHA KVFIEAVVEL SQK

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AM286690 Genomic DNA. Translation: CAL17675.1.
RefSeqYP_693947.1. NC_008260.1.

3D structure databases

ProteinModelPortalQ0VMC3.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ0VMC3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4212185.
GenomeReviewsGene locus ABO_2227 in contig AM286690_GR.
KEGGabo:ABO_2227.
NMPDRfig|393595.12.peg.2227.
PATRIC20842325. VBIAlcBor124741_2331.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0407.
HOGENOMHBG628392.
OMAPRIHFGV.
PhylomeDBQ0VMC3.

Enzyme and pathway databases

BioCycABOR393595:ABO_2227-MONOMER.

Family and domain databases

HAMAPMF_00218. URO-D.
[Tree]
InterProIPR006361. Uroporphyrinogen_deCO2ase_HemE.
IPR000257. Uroporphyrinogen_deCOase.
[Graphical view]
KOK01599.
PANTHERPTHR21091:SF2. HemE. 1 hit.
PfamPF01208. URO-D. 1 hit.
[Graphical view]
TIGRFAMsTIGR01464. HemE. 1 hit.
PROSITEPS00906. UROD_1. 1 hit.
PS00907. UROD_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDCUP_ALCBS
AccessionPrimary (citable) accession number: Q0VMC3
Entry history
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: September 5, 2006
Last modified: January 25, 2012
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents