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Reviewed, UniProtKB/Swiss-Prot Q0VMC3 (DCUP_ALCBS)

Last modified June 16, 2009. Version 27. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Uroporphyrinogen decarboxylase
      Short name=URO-D
      Short name=UPD
    EC=4.1.1.37
Gene names
Name: hemE
Ordered Locus Names: ABO_2227
OrganismAlcanivorax borkumensis (strain SK2 / ATCC 700651 / DSM 11573) [Complete proteome] [HAMAP]
Taxonomic identifier393595 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Oceanospirillales › Alcanivoracaceae › Alcanivorax

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Protein attributes

Sequence length353 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

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General annotation (Comments)

Function

Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III By similarity.

Catalytic activity

Uroporphyrinogen III = coproporphyrinogen + 4 CO2. HAMAP MF_00218

Pathway

Porphyrin metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 4/4. HAMAP MF_00218

Subunit structure

Homodimer By similarity.

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the uroporphyrinogen decarboxylase family.

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Ontologies

Keywords
   Biological processPorphyrin biosynthesis
   Cellular componentCytoplasm
   Molecular functionDecarboxylase
Lyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processporphyrin biosynthetic process

Inferred from electronic annotation. Source: HAMAP

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionuroporphyrinogen decarboxylase activity

Inferred from electronic annotation. Source: HAMAP

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 353353Uroporphyrinogen decarboxylase HAMAP MF_00218
PRO_0000325620

Regions

Region29 – 335Substrate binding By similarity

Sites

Binding site791Substrate By similarity
Binding site1561Substrate By similarity
Binding site2111Substrate By similarity
Binding site3291Substrate By similarity
Site791Transition state stabilizer By similarity

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Sequences

Sequence LengthMass (Da)Tools
Q0VMC3-1 [UniParc].

Last modified September 5, 2006. Version 1.
Checksum: 1C23D2AA76CFFD4F

FASTA35338,968
        10         20         30         40         50         60 
MTFAPLQNDR FLRALNRETV DRTPIWMMRQ AGRYLPEYRA AREHAGSFMD LCKNADLACE 

        70         80         90        100        110        120 
VTLQPLERYP LDAAILFSDI LTIPDAMGLG LYFETGEGPK FRKVVRTEAD VAALPIPDAE 

       130        140        150        160        170        180 
SDLGYVMNAV STIRGALNGR VPLIGFSGSP WTLATYMVEG GSSKDFRHLK AMVYSQPELA 

       190        200        210        220        230        240 
HAMLDKLAQS VTGYLNAQIR HGAQAVQIFD TWGGALSAEA YKEFSLRYMQ QIVDGLIRDN 

       250        260        270        280        290        300 
EGRKVPVILF TKNGGLWLES MAATGCDALG LDWTINIGDA RRRVGDKVAL QGNMDPAVLY 

       310        320        330        340        350 
ASPQAIRAEV KRILDDFGDH PGHIFNLGHG ITPQVDPEHA KVFIEAVVEL SQK

« Hide

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Cross-references

Sequence databases

AM286690 Genomic DNA. Translation: CAL17675.1.
RefSeqYP_693947.1.

3D structure databases

ModBaseSearch...

Genome annotation databases

GeneID4212185.
GenomeReviewsGene locus ABO_2227 in contig AM286690_GR.
KEGGabo:ABO_2227.
NMPDRfig|393595.12.peg.2227.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMQ0VMC3.
OMAQ0VMC3. VFTKGGG.

Enzyme and pathway databases

BioCycABOR393595:ABO_2227-MON.

Family and domain databases

HAMAPMF_00218.
[Tree]
InterProIPR006361. Uroporphyrinogen_deCO2ase_HemE.
IPR000257. Uroporphyrinogen_deCOase.
[Graphical view]
PANTHERPTHR21091:SF2. HemE. 1 hit.
PfamPF01208. URO-D. 1 hit.
[Graphical view]
ProDomPD003225. Uro_decarbxyls. 1 hit.
[Graphical view] [Entries sharing at least one domain]
TIGRFAMsTIGR01464. hemE. 1 hit.
PROSITEPS00906. UROD_1. 1 hit.
PS00907. UROD_2. 1 hit.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry nameDCUP_ALCBS
AccessionPrimary (citable) accession number: Q0VMC3
Entry history
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: September 5, 2006
Last modified: June 16, 2009
This is version 27 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

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Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents