Reviewed, UniProtKB/Swiss-Prot Q0VM71 (HIS4_ALCBS)

Names and origin

Protein names

Recommended name:
    1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase
    EC=5.3.1.16
Alternative name(s):
    Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase

Gene names

Name:	hisA
Ordered Locus Names:	ABO_2279

Organism

Alcanivorax borkumensis (strain SK2 / ATCC 700651 / DSM 11573) [Complete proteome] [HAMAP]

Taxonomic identifier

393595 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Oceanospirillales › Alcanivoracaceae › Alcanivorax

Protein attributes

Sequence length	246 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	1-(5-phosphoribosyl)-5-((5-phosphoribosylamino)methylideneamino)imidazole-4-carboxamide = 5-((5-phospho-1-deoxyribulos-1-ylamino)methylideneamino)-1-(5-phosphoribosyl)imidazole-4-carboxamide. HAMAP MF_01014
Pathway	Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 4/9. HAMAP MF_01014
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the hisA/hisF family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Histidine biosynthesis
Cellular component	Cytoplasm
Molecular function	Isomerase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	histidine biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 246	246	1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase HAMAP MF_01014		PRO_0000290444
Sites
	Active site	8	1	Proton acceptor By similarity
	Active site	130	1	Proton donor By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q0VM71-1 [UniParc]. Last modified June 12, 2007. Version 2. Checksum: C86884857D33B682	FASTA	246	26,018
	10 20 30 40 50 60 MLLIPAIDLK DGKCVRLKQG RMEDDTVFSE DPVAVASHWV ERGARRLHLV DLNGAFAGEP 70 80 90 100 110 120 VNGDIVKAIA KAHPDLPIQI GGGIRSPEII QAYLDAGVQW VIIGTKAVNE PAFVKAMCEQ 130 140 150 160 170 180 FPGHIIVGLD AKDGKVATDG WANVTDVDVI DLAKQFENDG VSAIVYTDIS RDGMLQGVNV 190 200 210 220 230 240 DATVRLAQSM SIPVIASGGI TNLDDVRNLC AVADQGISGA ITGRAIYENT LDFADGQALS DELSGA

References

[1]

"Genome sequence of the ubiquitous hydrocarbon-degrading marine bacterium Alcanivorax borkumensis." Schneiker S., Martins dos Santos V.A.P., Bartels D., Bekel T., Brecht M., Buhrmester J., Chernikova T.N., Denaro R., Ferrer M., Gertler C., Goesmann A., Golyshina O.V., Kaminski F., Khachane A.N., Lang S., Linke B., McHardy A.C., Meyer F. , Nechitaylo T., Puehler A., Regenhardt D., Rupp O., Sabirova J.S., Selbitschka W., Yakimov M.M., Timmis K.N., Vorhoelter F.-J., Weidner S., Kaiser O., Golyshin P.N. Nat. Biotechnol. 24:997-1004(2006) [PubMed: 16878126] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AM286690 Genomic DNA. Translation: CAL17727.1. Different initiation.
RefSeq	YP_693999.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	4212197.
GenomeReviews	Gene locus ABO_2279 in contig AM286690_GR.
KEGG	abo:ABO_2279.
NMPDR	fig|393595.12.peg.2281.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q0VM71.
Enzyme and pathway databases
BioCyc	ABOR393595:ABO_2279-MON.
Family and domain databases
HAMAP	MF_01014. [Tree]
InterPro	IPR006063. His4. IPR006062. His_biosynth. [Graphical view]
Pfam	PF00977. His_biosynth. 1 hit. [Graphical view]
TIGRFAMs	TIGR00007. His4. 1 hit.
ProtoNet	Search...

Entry information

Entry name

HIS4_ALCBS

Accession

Primary (citable) accession number: Q0VM71

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 12, 2007
Last sequence update:	June 12, 2007
Last modified:	June 16, 2009
This is version 19 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)