Reviewed, UniProtKB/Swiss-Prot Q0VM25 (ARLY_ALCBS)

Names and origin

Protein names

Recommended name:
    Argininosuccinate lyase
      Short name=ASAL
    EC=4.3.2.1
Alternative name(s):
    Arginosuccinase

Gene names

Name:	argH
Ordered Locus Names:	ABO_2325

Organism

Alcanivorax borkumensis (strain SK2 / ATCC 700651 / DSM 11573) [Complete proteome] [HAMAP]

Taxonomic identifier

393595 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Oceanospirillales › Alcanivoracaceae › Alcanivorax

Protein attributes

Sequence length	464 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	2-(N(omega)-L-arginino)succinate = fumarate + L-arginine. HAMAP MF_00006
Pathway	Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 3/3. HAMAP MF_00006
Subcellular location	Cytoplasm Probable.
Sequence similarities	Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Arginine biosynthesis
Cellular component	Cytoplasm
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine biosynthetic process via ornithine Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	argininosuccinate lyase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 464	464	Argininosuccinate lyase HAMAP MF_00006		PRO_1000000450

Sequences

	Sequence		Length	Mass (Da)
	Q0VM25-1 [UniParc]. Last modified September 5, 2006. Version 1. Checksum: AA9D7479ED61EAF2	FASTA	464	52,247
	10 20 30 40 50 60 MTDKQQNKLW GGRFSESTDQ FVQEFTASVN FDRRMYRQDI YGSQAHATML AEVGVLTDEE 70 80 90 100 110 120 RDAIIVGLRE IQLEIENGEF QWSVALEDVH MNIEARLTDK IGITGKKLHT GRSRNDQVAT 130 140 150 160 170 180 DIRLWLRDEL LILEEQFLHL MQGLLNLAER EAATIMPGFT HLQTAQPVTF GHHLLAWFEM 190 200 210 220 230 240 LKRDRERLLD CKKRVNRMPL GAAALAGTTY PINRERTCEL LGFDGVCENS LDAVSDRDFA 250 260 270 280 290 300 IEFCAMAALT MTHLSRISEE LVLWTSAQFN FINLPDRFCT GSSIMPQKKN PDVPELVRGK 310 320 330 340 350 360 TGRVNGHLIS LLTLMKSQPL AYNKDNQEDK EPLYDAVDTL KGSLRAFGDM IPALEPNREV 370 380 390 400 410 420 MREAARRGFA TATDLADYLV RKGIAFRDSH EIVGKAVAYG VEKKKDLGDM SLSELKQFSD 430 440 450 460 QIEDNVFEVL TLEGSVSARN HIGGTAPDQV RAAVARAREA LDNT

References

[1]

"Genome sequence of the ubiquitous hydrocarbon-degrading marine bacterium Alcanivorax borkumensis." Schneiker S., Martins dos Santos V.A.P., Bartels D., Bekel T., Brecht M., Buhrmester J., Chernikova T.N., Denaro R., Ferrer M., Gertler C., Goesmann A., Golyshina O.V., Kaminski F., Khachane A.N., Lang S., Linke B., McHardy A.C., Meyer F. , Nechitaylo T., Puehler A., Regenhardt D., Rupp O., Sabirova J.S., Selbitschka W., Yakimov M.M., Timmis K.N., Vorhoelter F.-J., Weidner S., Kaiser O., Golyshin P.N. Nat. Biotechnol. 24:997-1004(2006) [PubMed: 16878126] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AM286690 Genomic DNA. Translation: CAL17773.1.
RefSeq	YP_694045.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	4213482.
GenomeReviews	Gene locus ABO_2325 in contig AM286690_GR.
KEGG	abo:ABO_2325.
NMPDR	fig|393595.12.peg.2326.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q0VM25.
OMA	Q0VM25. ATDTRLY.
Enzyme and pathway databases
BioCyc	ABOR393595:ABO_2325-MON.
Family and domain databases
HAMAP	MF_00006. [Tree]
InterPro	IPR009049. Argininosuccinate_lyase. IPR003031. D_crystallin. IPR000362. Fumarate_lyase. [Graphical view]
PANTHER	PTHR11444:SF3. argH. 1 hit.
Pfam	PF00206. Lyase_1. 1 hit. [Graphical view]
PRINTS	PR00145. DCRYSTALLIN. PR00149. FUMRATELYASE.
TIGRFAMs	TIGR00838. argH. 1 hit.
PROSITE	PS00163. FUMARATE_LYASES. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ARLY_ALCBS

Accession

Primary (citable) accession number: Q0VM25

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	September 5, 2006
Last modified:	June 16, 2009
This is version 26 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)