ID   TYSY_ALCBS              Reviewed;         277 AA.
AC   Q0VM06;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-SEP-2006, sequence version 1.
DT   16-JUN-2009, entry version 27.
DE   RecName: Full=Thymidylate synthase;
DE            Short=TS;
DE            Short=TSase;
DE            EC=2.1.1.45;
GN   Name=thyA; OrderedLocusNames=ABO_2344;
OS   Alcanivorax borkumensis (strain SK2 / ATCC 700651 / DSM 11573).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Oceanospirillales;
OC   Alcanivoracaceae; Alcanivorax.
OX   NCBI_TaxID=393595;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16878126; DOI=10.1038/nbt1232;
RA   Schneiker S., Martins dos Santos V.A.P., Bartels D., Bekel T.,
RA   Brecht M., Buhrmester J., Chernikova T.N., Denaro R., Ferrer M.,
RA   Gertler C., Goesmann A., Golyshina O.V., Kaminski F., Khachane A.N.,
RA   Lang S., Linke B., McHardy A.C., Meyer F., Nechitaylo T., Puehler A.,
RA   Regenhardt D., Rupp O., Sabirova J.S., Selbitschka W., Yakimov M.M.,
RA   Timmis K.N., Vorhoelter F.-J., Weidner S., Kaiser O., Golyshin P.N.;
RT   "Genome sequence of the ubiquitous hydrocarbon-degrading marine
RT   bacterium Alcanivorax borkumensis.";
RL   Nat. Biotechnol. 24:997-1004(2006).
CC   -!- FUNCTION: Provides the sole de novo source of dTMP for DNA
CC       biosynthesis (By similarity).
CC   -!- CATALYTIC ACTIVITY: 5,10-methylenetetrahydrofolate + dUMP =
CC       dihydrofolate + dTMP.
CC   -!- PATHWAY: Pyrimidine metabolism; dTTP biosynthesis.
CC   -!- SUBUNIT: Homodimer (By similarity).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC   -!- SIMILARITY: Belongs to the thymidylate synthase family. Bacterial-
CC       type thyA subfamily.
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DR   EMBL; AM286690; CAL17792.1; -; Genomic_DNA.
DR   RefSeq; YP_694064.1; -.
DR   GeneID; 4211942; -.
DR   GenomeReviews; AM286690_GR; ABO_2344.
DR   KEGG; abo:ABO_2344; -.
DR   NMPDR; fig|393595.12.peg.2345; -.
DR   HOGENOM; Q0VM06; -.
DR   OMA; Q0VM06; LGPVYGH.
DR   BioCyc; ABOR393595:ABO_2344-MON; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0004799; F:thymidylate synthase activity; IEA:HAMAP.
DR   GO; GO:0006231; P:dTMP biosynthetic process; IEA:HAMAP.
DR   HAMAP; MF_00008; -; 1.
DR   InterPro; IPR000398; Thymidylat_synth_C.
DR   Gene3D; G3DSA:3.30.572.10; Thymidylat_synth_C; 1.
DR   PANTHER; PTHR11549:SF2; Thymidylat_synth_C; 1.
DR   Pfam; PF00303; Thymidylat_synt; 1.
DR   PRINTS; PR00108; THYMDSNTHASE.
DR   ProDom; PD001180; Thymidylat_synth; 1.
DR   TIGRFAMs; TIGR03284; thym_sym; 1.
DR   PROSITE; PS00091; THYMIDYLATE_SYNTHASE; FALSE_NEG.
PE   3: Inferred from homology;
KW   Complete proteome; Cytoplasm; Methyltransferase;
KW   Nucleotide biosynthesis; Transferase.
FT   CHAIN         1    277       Thymidylate synthase.
FT                                /FTId=PRO_1000000571.
FT   ACT_SITE    159    159       By similarity.
SQ   SEQUENCE   277 AA;  31049 MW;  7807D5D137C0D0A3 CRC64;
     MKQYLDLLRH VREHGTYKED RTGTGTYAVF GYQMRYDLSQ GFPMLTTKKL HLRSIIHELL
     WFLSGDTNIR YLKENGVSIW DGWATPEGEL GPVYGEQWRS WKTADGGVID QITEVLKEIK
     RNPDSRRLVV SAWNPAVLPD PSISPDANAA AGKQALPPCH CLFQFYVADG KLSCQLYQRS
     GDIFLGVPFN IASYALLTLM MAQVCDLQPG DFVHTLGDAH LYSNHLEQAD TQLARTPGPL
     PTMTLNPAVK DLFAFTFDDF TVSNYNPDAH IKAPVAI
//