Reviewed, UniProtKB/Swiss-Prot Q0VLA8 (GCSPA_ALCBS)

Names and origin

Protein names

Recommended name:
    Probable glycine dehydrogenase [decarboxylating] subunit 1
    EC=1.4.4.2
Alternative name(s):
    Glycine decarboxylase subunit 1
    Glycine cleavage system P-protein subunit 1

Gene names

Name:	gcvPA
Ordered Locus Names:	ABO_2592

Organism

Alcanivorax borkumensis (strain SK2 / ATCC 700651 / DSM 11573) [Complete proteome] [HAMAP]

Taxonomic identifier

393595 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Oceanospirillales › Alcanivoracaceae › Alcanivorax

Protein attributes

Sequence length	452 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity.
Catalytic activity	Glycine + H-protein-lipoyllysine = H-protein-S-aminomethyldihydrolipoyllysine + CO2. HAMAP MF_00712
Subunit structure	The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is an heterodimer of two subunits By similarity.
Sequence similarities	Belongs to the gcvP family. N-terminal subunit subfamily.

Ontologies

Keywords
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	glycine decarboxylation via glycine cleavage system Inferred from electronic annotation. Source: HAMAP oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	glycine dehydrogenase (decarboxylating) activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 452	452	Probable glycine dehydrogenase [decarboxylating] subunit 1 HAMAP MF_00712		PRO_1000045634

Sequences

	Sequence		Length	Mass (Da)
	Q0VLA8-1 [UniParc]. Last modified September 5, 2006. Version 1. Checksum: C06CE02A24606C06	FASTA	452	48,258
	10 20 30 40 50 60 MPYIPHTPDD VRAMLDAIGA DSIEDLFDEI PSHLKAAGKL DALPEGLSEM DVTRLMSDRA 70 80 90 100 110 120 AQDAGAVSFI GAGAYQHHVP AAVWEIATRG EFYTAYTPYQ AEASQGTLQV IYEFQTLMTR 130 140 150 160 170 180 LTGMDVSNAS VYDGASGLAE AVLMSLRANR KSKSRKVLVP TAVNPRYTSA TQAIVENQDV 190 200 210 220 230 240 ALERVGFDAA SGQTPLDALK PYEGEDYAAL VISQPNFFGS LEEVDALTDW AHANKMLVIG 250 260 270 280 290 300 VVNPTSLALL TPPGEWGADG ADIVVGEGQP LGVPLSSGGP YFGFMCCKQK HVRQMPGRII 310 320 330 340 350 360 GRTVDMEGKQ GFTLTLQARE QHIRRSKATS NICTNQGLAM TAATIYTSLL GPDGLGNVAA 370 380 390 400 410 420 HCHANTQALA DKLTAIDGVE RAFTAPTFHE VVLTLPKPAD QVLAALAEKD VLGGVSLAGD 430 440 450 YDMNNAILVN ATEVHSEQDL QLFEQALKEV LA

References

[1]

"Genome sequence of the ubiquitous hydrocarbon-degrading marine bacterium Alcanivorax borkumensis." Schneiker S., Martins dos Santos V.A.P., Bartels D., Bekel T., Brecht M., Buhrmester J., Chernikova T.N., Denaro R., Ferrer M., Gertler C., Goesmann A., Golyshina O.V., Kaminski F., Khachane A.N., Lang S., Linke B., McHardy A.C., Meyer F. , Nechitaylo T., Puehler A., Regenhardt D., Rupp O., Sabirova J.S., Selbitschka W., Yakimov M.M., Timmis K.N., Vorhoelter F.-J., Weidner S., Kaiser O., Golyshin P.N. Nat. Biotechnol. 24:997-1004(2006) [PubMed: 16878126] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AM286690 Genomic DNA. Translation: CAL18040.1.
RefSeq	YP_694312.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	4211691.
GenomeReviews	Gene locus ABO_2592 in contig AM286690_GR.
KEGG	abo:ABO_2592.
NMPDR	fig|393595.12.peg.2596.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q0VLA8.
OMA	Q0VLA8. VANASMY.
Enzyme and pathway databases
BioCyc	ABOR393595:ABO_2592-MON.
Family and domain databases
HAMAP	MF_00712. [Tree]
InterPro	IPR003437. GDC-P. [Graphical view]
PANTHER	PTHR11773. GDC-P. 1 hit.
Pfam	PF02347. GDC-P. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GCSPA_ALCBS

Accession

Primary (citable) accession number: Q0VLA8

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	September 5, 2006
Last modified:	June 16, 2009
This is version 23 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)