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Q0VLA8

- GCSPA_ALCBS

UniProt

Q0VLA8 - GCSPA_ALCBS

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Protein
Probable glycine dehydrogenase (decarboxylating) subunit 1
Gene
gcvPA, ABO_2592
Organism
Alcanivorax borkumensis (strain SK2 / ATCC 700651 / DSM 11573)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine catabolic process Source: InterPro
  2. nucleoside metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Enzyme and pathway databases

BioCyciABOR393595:GHRI-2643-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glycine dehydrogenase (decarboxylating) subunit 1 (EC:1.4.4.2)
Alternative name(s):
Glycine cleavage system P-protein subunit 1
Glycine decarboxylase subunit 1
Glycine dehydrogenase (aminomethyl-transferring) subunit 1
Gene namesi
Name:gcvPA
Ordered Locus Names:ABO_2592
OrganismiAlcanivorax borkumensis (strain SK2 / ATCC 700651 / DSM 11573)
Taxonomic identifieri393595 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaOceanospirillalesAlcanivoracaceaeAlcanivorax
ProteomesiUP000008871: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 452452Probable glycine dehydrogenase (decarboxylating) subunit 1UniRule annotation
PRO_1000045634Add
BLAST

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits By similarity.

Protein-protein interaction databases

STRINGi393595.ABO_2592.

Structurei

3D structure databases

ProteinModelPortaliQ0VLA8.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0403.
HOGENOMiHOG000132025.
KOiK00282.
OMAiFFHEAVL.
OrthoDBiEOG6XWV3B.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
HAMAPiMF_00712. GcvPA.
InterProiIPR023010. GcvPA.
IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 1 hit.
[Graphical view]
PIRSFiPIRSF006815. GcvPA. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.

Sequencei

Sequence statusi: Complete.

Q0VLA8-1 [UniParc]FASTAAdd to Basket

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MPYIPHTPDD VRAMLDAIGA DSIEDLFDEI PSHLKAAGKL DALPEGLSEM    50
DVTRLMSDRA AQDAGAVSFI GAGAYQHHVP AAVWEIATRG EFYTAYTPYQ 100
AEASQGTLQV IYEFQTLMTR LTGMDVSNAS VYDGASGLAE AVLMSLRANR 150
KSKSRKVLVP TAVNPRYTSA TQAIVENQDV ALERVGFDAA SGQTPLDALK 200
PYEGEDYAAL VISQPNFFGS LEEVDALTDW AHANKMLVIG VVNPTSLALL 250
TPPGEWGADG ADIVVGEGQP LGVPLSSGGP YFGFMCCKQK HVRQMPGRII 300
GRTVDMEGKQ GFTLTLQARE QHIRRSKATS NICTNQGLAM TAATIYTSLL 350
GPDGLGNVAA HCHANTQALA DKLTAIDGVE RAFTAPTFHE VVLTLPKPAD 400
QVLAALAEKD VLGGVSLAGD YDMNNAILVN ATEVHSEQDL QLFEQALKEV 450
LA 452
Length:452
Mass (Da):48,258
Last modified:September 5, 2006 - v1
Checksum:iC06CE02A24606C06
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM286690 Genomic DNA. Translation: CAL18040.1.
RefSeqiYP_694312.1. NC_008260.1.

Genome annotation databases

EnsemblBacteriaiCAL18040; CAL18040; ABO_2592.
GeneIDi4211691.
KEGGiabo:ABO_2592.
PATRICi20843077. VBIAlcBor124741_2705.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM286690 Genomic DNA. Translation: CAL18040.1 .
RefSeqi YP_694312.1. NC_008260.1.

3D structure databases

ProteinModelPortali Q0VLA8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 393595.ABO_2592.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAL18040 ; CAL18040 ; ABO_2592 .
GeneIDi 4211691.
KEGGi abo:ABO_2592.
PATRICi 20843077. VBIAlcBor124741_2705.

Phylogenomic databases

eggNOGi COG0403.
HOGENOMi HOG000132025.
KOi K00282.
OMAi FFHEAVL.
OrthoDBi EOG6XWV3B.

Enzyme and pathway databases

BioCyci ABOR393595:GHRI-2643-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
HAMAPi MF_00712. GcvPA.
InterProi IPR023010. GcvPA.
IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 1 hit.
[Graphical view ]
PIRSFi PIRSF006815. GcvPA. 1 hit.
SUPFAMi SSF53383. SSF53383. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SK2 / ATCC 700651 / DSM 11573.

Entry informationi

Entry nameiGCSPA_ALCBS
AccessioniPrimary (citable) accession number: Q0VLA8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: September 5, 2006
Last modified: September 3, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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