Reviewed, UniProtKB/Swiss-Prot Q0VLA6 (GCST_ALCBS)

Names and origin

Protein names

Recommended name:
    Aminomethyltransferase
    EC=2.1.2.10
Alternative name(s):
    Glycine cleavage system T protein

Gene names

Name:	gcvT
Ordered Locus Names:	ABO_2594

Organism

Alcanivorax borkumensis (strain SK2 / ATCC 700651 / DSM 11573) [Complete proteome] [HAMAP]

Taxonomic identifier

393595 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Oceanospirillales › Alcanivoracaceae › Alcanivorax

Protein attributes

Sequence length	359 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	The glycine cleavage system catalyzes the degradation of glycine By similarity. HAMAP MF_00259
Catalytic activity	[Protein]-S(8)-aminomethyldihydrolipoyllysine + tetrahydrofolate = [protein]-dihydrolipoyllysine + 5,10-methylenetetrahydrofolate + NH3. HAMAP MF_00259
Subunit structure	The glycine cleavage system is composed of four proteins: P, T, L and H By similarity. HAMAP MF_00259
Sequence similarities	Belongs to the gcvT family.

Ontologies

Keywords
Molecular function	Aminotransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	glycine decarboxylation via glycine cleavage system Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: InterPro
Molecular function	aminomethyltransferase activity Inferred from electronic annotation. Source: HAMAP transaminase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 359	359	Aminomethyltransferase HAMAP MF_00259		PRO_1000047643

Sequences

	Sequence		Length	Mass (Da)
	Q0VLA6-1 [UniParc]. Last modified September 5, 2006. Version 1. Checksum: 33D8B0E2D0C7EA74	FASTA	359	39,186
	10 20 30 40 50 60 MAHRTALYDA HLAAGGKMVD FGGWDMPINY GSQIEEHHAV RQNAGVFDVS HMTVVDIAGA 70 80 90 100 110 120 GARDYLRQLL ANDVDRIDPG RALYTGMLND NGGVIDDLIV YKRDNDYRLV VNCATRETDL 130 140 150 160 170 180 GWMEKHAGGF AVDIHERPEL AMLAIQGPKA RDILAGLLNG SRADAVKSLK VFAFAEDGDW 190 200 210 220 230 240 MIARTGYTGE DGVEIMLPNA DALTLWEQLL EAGVSPIGLG ARDTLRLEAG LNLYGNDMDE 250 260 270 280 290 300 SITPWEANMG WTVMLNDREF IGRQPLLNQK ENGHSEQVGL ILEGKGVLRA HQKVLMPNGE 310 320 330 340 350 EGEITSGTFS PTLGKSIALA RLPAGATGKV DVEIRNKRQV AQVVKPPFVR NGNAVYKEQ

References

[1]

"Genome sequence of the ubiquitous hydrocarbon-degrading marine bacterium Alcanivorax borkumensis." Schneiker S., Martins dos Santos V.A.P., Bartels D., Bekel T., Brecht M., Buhrmester J., Chernikova T.N., Denaro R., Ferrer M., Gertler C., Goesmann A., Golyshina O.V., Kaminski F., Khachane A.N., Lang S., Linke B., McHardy A.C., Meyer F. , Nechitaylo T., Puehler A., Regenhardt D., Rupp O., Sabirova J.S., Selbitschka W., Yakimov M.M., Timmis K.N., Vorhoelter F.-J., Weidner S., Kaiser O., Golyshin P.N. Nat. Biotechnol. 24:997-1004(2006) [PubMed: 16878126] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AM286690 Genomic DNA. Translation: CAL18042.1.
RefSeq	YP_694314.1.
3D structure databases
SMR	Q0VLA6. Positions 4-355.
ModBase	Search...
Protein-protein interaction databases
STRING	Q0VLA6.
Genome annotation databases
GeneID	4211692.
GenomeReviews	Gene locus ABO_2594 in contig AM286690_GR.
KEGG	abo:ABO_2594.
NMPDR	fig|393595.12.peg.2598.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0404.
HOGENOM	HBG299834.
OMA	KALYGGM.
PhylomeDB	Q0VLA6.
Enzyme and pathway databases
BioCyc	ABOR393595:ABO_2594-MONOMER.
Family and domain databases
HAMAP	MF_00259. GcvT. [Tree]
InterPro	IPR013977. GCV_T_C. IPR006222. GCV_T_N. IPR006223. GcvT. [Graphical view]
Pfam	PF01571. GCV_T. 1 hit. PF08669. GCV_T_C. 1 hit. [Graphical view]
PIRSF	PIRSF006487. GcvT. 1 hit.
TIGRFAMs	TIGR00528. gcvT. 1 hit.
ProtoNet	Search...

Entry information

Entry name

GCST_ALCBS

Accession

Primary (citable) accession number: Q0VLA6

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	September 5, 2006
Last modified:	February 9, 2010
This is version 31 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)