Unreviewed, UniProtKB/TrEMBL Q0VIN8 (Q0VIN8_HUMAN)

Names and origin

Protein names

Recommended name:
    Ubiquitin carboxyl-terminal hydrolase RuleBase RU004435V0
    EC=3.1.2.15

Gene names

Name:

USP42 EMBL AAT67238.1

Organism

Homo sapiens (Human) EMBL AAT67238.1

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	1324 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Catalytic activity	Ubiquitin C-terminal thioester + H(2)O = ubiquitin + a thiol. RuleBase RU004435V0
Sequence similarities	Belongs to the peptidase C19 family. RuleBase RU004434V0

Ontologies

Keywords
Biological process	Ubl conjugation pathway RuleBase RU004434V0
Molecular function	Hydrolase Protease Thiol protease RuleBase RU004434V0
Gene Ontology (GO)
Uncategorized	ubiquitin cycle Inferred from electronic annotation. Source: UniProtKB-KW
Biological process	ubiquitin-dependent protein catabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	ubiquitin thiolesterase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q0VIN8-1 [UniParc]. Last modified September 5, 2006. Version 1. Checksum: C24DB3C6D1970839	FASTA	1,324	145,421
	10 20 30 40 50 60 MTIVDKASES SDPSAYQNQP GSSEAVSPGD MDAGSASWGA VSSLNDVSNH TLSLGPVPGA 70 80 90 100 110 120 VVYSSSSVPD KSKPSPQKDQ ALGDGIAPPQ KVLFPSEKIC LKWQQTHRVG AGLQNLGNTC 130 140 150 160 170 180 FANAALQCLT YTPPLANYML SHEHSKTCHA EGFCMMCTMQ AHITQALSNP GDVIKPMFVI 190 200 210 220 230 240 NEMRRIARHF RFGNQEDAHE FLQYTVDAMQ KACLNGSNKL DRHTQATTLV CQIFGGYLRS 250 260 270 280 290 300 RVKCLNCKGV SDTFDPYLDI TLEIKAAQSV NKALEQFVKP EQLDGENSYK CSKCKKMVPA 310 320 330 340 350 360 SKRFTIHRSS NVLTLSLKRF ANFTGGKIAK DVKYPEYLDI RPYMSQPNGE PIVYVLYAVL 370 380 390 400 410 420 VHTGFNCHAG HYFCYIKASN GLWYQMNDSI VSTSDIRSVL SQQAYVLFYI RSHDVKNGGE 430 440 450 460 470 480 LTHPTHSPGQ SSPRPVISQR VVTNKQAAPG FIGPQLPSHM IKNPPHLNGT GPLKDTPSSS 490 500 510 520 530 540 MSSPNGNSSV NRASPVNASA SVQNWSVNRS SVIPEHPKKQ KITISIHNKL PVRQCQSQPN 550 560 570 580 590 600 LHSNSLENPT KPVPSSTITN SAVQSTSNAS TMSVSSKVTK PIPRSESCSQ PVMNGKSKLN 610 620 630 640 650 660 SSVLVPYGAE SSEDSDEESK GLGKENGIGT IVSSHSPGQD AEDEEATPHE LQEPMTLNGA 670 680 690 700 710 720 NSADSDSDPK ENGLAPDGAS CQGQPALHSE NPFAKANGLP GKLMPAPLLS LPEDKILETF 730 740 750 760 770 780 RLSNKLKGST DEMSAPGAER GPPEDRDAEP QPGSPAAESL EEPDAAAGLS STKKAPPPRD 790 800 810 820 830 840 PGTPATKEGA WEAMAVAPEE PPPSAGEDIV GDTAPPDLCD PGSLTGDASP LSQDAKGMIA 850 860 870 880 890 900 EGPRDSALAE APEGLSPAPP ARSEEPCEQP LLVHPSGDHA RDAQDPSQSL GAPEAAERPP 910 920 930 940 950 960 APVLDMAPAG HPEGDAEPSP GERVEDAAAP KAPGPSPAKE KIGSLRKVDR GHYRSRRERS 970 980 990 1000 1010 1020 SSGEPARESR SKTEGHRHRR RRTCPRERDR QDRHAPEHHP GHGDRLSPGE RRSLGRCSHH 1030 1040 1050 1060 1070 1080 HSRHRSGVEL DWVRHHYTEG ERGWGREKFY PDRPRWDRCR YYHDRYALYA ARDWKPFHGG 1090 1100 1110 1120 1130 1140 REHERAGLHE RPHKDHNRGR RGCEPARERE RHRPSSPRAG APHALAPHPD RFSHDRTALV 1150 1160 1170 1180 1190 1200 AGDNCNLSDR FHEHENGKSR KRRHDSVENS DSHVEKKARR SEQKDPLEEP KAKKHKKSKK 1210 1220 1230 1240 1250 1260 KKKSKDKHRD RDSRHQRDSD LSAACSDADL HRHKKKKKKK KRHSRKSEDF VKDSELHLPR 1270 1280 1290 1300 1310 1320 VTSLETVAQF RRAQGGFPLS GGPPLEGVGP FREETKHLRM ESRDDRCRLF EYGQGKRRYL ELGR

References

[1]	"A discovery of a novel deubiquitinating enzyme human USP42." Baek K.-H., Yoo K.-J. Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AY618868 mRNA. Translation: AAT67238.1.
UniGene	Hs.31856 Hs.681841
3D structure databases
ModBase	Search...
Genome annotation databases
Ensembl	ENSG00000106346. Homo sapiens. [Contig view]
Organism-specific databases
HGNC	HGNC:20068. USP42.
GenAtlas	Search...
GeneCards	Search...
Phylogenomic databases
HOVERGEN	Q0VIN8.
Gene expression databases
ArrayExpress	Q0VIN8.
Family and domain databases
InterPro	IPR003006. Ig/MHC_CS. IPR001394. Peptidase_C19. [Graphical view]
Pfam	PF00443. UCH. 1 hit. [Graphical view]
PROSITE	PS00290. IG_MHC. 1 hit. Uncertain. PS00972. UCH_2_1. 1 hit. PS00973. UCH_2_2. 1 hit. PS50235. UCH_2_3. 1 hit. [Graphical view]

Entry information

Entry name

Q0VIN8_HUMAN

Accession

Primary (citable) accession number: Q0VIN8

Entry history

Integrated into UniProtKB/TrEMBL:	September 5, 2006
Last sequence update:	September 5, 2006
Last modified:	July 22, 2008
This is version 15 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)