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Protein

Protein TANC1

Gene

Tanc1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May be a scaffold component in the postsynaptic density.By similarity

GO - Biological processi

  • dendritic spine maintenance Source: MGI
  • myoblast fusion Source: MGI
  • visual learning Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Protein TANC1
Alternative name(s):
Tetratricopeptide repeat, ankyrin repeat and coiled-coil domain-containing protein 1
Gene namesi
Name:Tanc1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1914110. Tanc1.

Subcellular locationi

GO - Cellular componenti

  • axon terminus Source: MGI
  • cell junction Source: UniProtKB-KW
  • dendrite Source: MGI
  • neuronal cell body Source: MGI
  • postsynaptic density Source: UniProtKB-SubCell
  • postsynaptic membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 18561856Protein TANC1PRO_0000316960Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity
Modified residuei60 – 601PhosphoserineCombined sources
Modified residuei63 – 631PhosphoserineBy similarity
Modified residuei64 – 641PhosphoserineBy similarity
Modified residuei204 – 2041PhosphoserineBy similarity
Modified residuei267 – 2671PhosphoserineBy similarity
Modified residuei462 – 4621PhosphoserineBy similarity
Modified residuei1436 – 14361PhosphoserineBy similarity
Modified residuei1463 – 14631PhosphoserineBy similarity
Modified residuei1665 – 16651PhosphoserineCombined sources
Modified residuei1673 – 16731PhosphoserineCombined sources
Modified residuei1674 – 16741PhosphoserineCombined sources

Post-translational modificationi

Phosphorylated; by MINK1 and TNIK upon stimulation by RAP2A.By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ0VGY8.
MaxQBiQ0VGY8.
PaxDbiQ0VGY8.
PeptideAtlasiQ0VGY8.
PRIDEiQ0VGY8.

PTM databases

iPTMnetiQ0VGY8.
PhosphoSiteiQ0VGY8.

Expressioni

Gene expression databases

BgeeiENSMUSG00000035168.
ExpressionAtlasiQ0VGY8. baseline and differential.
GenevisibleiQ0VGY8. MM.

Interactioni

Subunit structurei

Interacts probably directly with DLG1, DLG4, HOMER1. Interacts with DLGAP1, INA, CAMK2A, GRIN2B and GRIA1. Interacts with TNIK and MINK1 (By similarity).By similarity

Protein-protein interaction databases

BioGridi211768. 1 interaction.
STRINGi10090.ENSMUSP00000036003.

Structurei

3D structure databases

ProteinModelPortaliQ0VGY8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati893 – 92533ANK 1Add
BLAST
Repeati931 – 96030ANK 2Add
BLAST
Repeati964 – 99330ANK 3Add
BLAST
Repeati997 – 102630ANK 4Add
BLAST
Repeati1037 – 106630ANK 5Add
BLAST
Repeati1075 – 110430ANK 6Add
BLAST
Repeati1108 – 113730ANK 7Add
BLAST
Repeati1141 – 117030ANK 8Add
BLAST
Repeati1174 – 120330ANK 9Add
BLAST
Repeati1207 – 123630ANK 10Add
BLAST
Repeati1240 – 126930ANK 11Add
BLAST
Repeati1286 – 131934TPR 1Add
BLAST
Repeati1333 – 136634TPR 2Add
BLAST
Repeati1368 – 140033TPR 3Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi167 – 24074Ser-richAdd
BLAST
Compositional biasi1647 – 168640Ser-richAdd
BLAST

Sequence similaritiesi

Belongs to the TANC family.Curated
Contains 11 ANK repeats.PROSITE-ProRule annotation
Contains 3 TPR repeats.PROSITE-ProRule annotation

Keywords - Domaini

ANK repeat, Repeat, TPR repeat

Phylogenomic databases

eggNOGiKOG0504. Eukaryota.
COG0666. LUCA.
GeneTreeiENSGT00840000129677.
HOGENOMiHOG000231045.
HOVERGENiHBG061464.
InParanoidiQ0VGY8.
OMAiEHRPRNT.
OrthoDBiEOG091G00QZ.
PhylomeDBiQ0VGY8.
TreeFamiTF323159.

Family and domain databases

Gene3Di1.25.40.10. 1 hit.
1.25.40.20. 4 hits.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR027417. P-loop_NTPase.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR019734. TPR_repeat.
[Graphical view]
PfamiPF00023. Ank. 1 hit.
PF12796. Ank_2. 3 hits.
[Graphical view]
SMARTiSM00248. ANK. 10 hits.
SM00028. TPR. 3 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
SSF48452. SSF48452. 1 hit.
SSF52540. SSF52540. 2 hits.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 6 hits.
PS50005. TPR. 3 hits.
PS50293. TPR_REGION. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q0VGY8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLKAVLKKSR EGGKGSKKEA GGDFGSETPA LSSSGDSPVN SLSTTEDTYR
60 70 80 90 100
VSLAKGVSMS LPSSPLLPRQ SLLTQSRSNK KSPGPVRKPK YVESPRVPGD
110 120 130 140 150
PVMIPFGEGS KPSEPSATEA KADNEPSCSP AAQELLTRLG FLLGEGIPSA
160 170 180 190 200
THITIEDKNE AMCTALSQGI SPCSTLTSST ASPSTDSPCS TLNSCVSKTA
210 220 230 240 250
ASKSPCETIS SPSSTLESKD SGIIATITSS SENDDRSGSS LEWNRDGSLR
260 270 280 290 300
LGVQKGVLHD RRADNCSPVA EEETTGSAES VLPKAEPSAG DGPVPYPQSS
310 320 330 340 350
GSLIMPRPNS VAATSSTKLE DLSYLDGQRN APLRTSIRLP WHNTAGGRAP
360 370 380 390 400
EVKARFAPYK PQEILLKPLL FEVPSITTDS VFVGRDWLFH QIEENLRNTE
410 420 430 440 450
LAENRGAVVV GSVGFGKTAI ISKLVALSCH GSRMRQIASS SPSLSPKSSD
460 470 480 490 500
PTQDLPGTPL LSPSSSTSAL SVTRTPAGPG TADSQRPRED AVKYLASKVV
510 520 530 540 550
AYHYCQADNT YTCLVPEFVH SIAALLCRSH QLAAYRDLLI KEPQLQSMLS
560 570 580 590 600
LRSCVQDPVA AFKRGVLEPL TSLRNEQKIP EEEYIILIDG LNEAEFHKPD
610 620 630 640 650
YGDTLSSFIT KIIPKFPTWL KLIVTVRANF QEIISALPFV KLSLDDFPDN
660 670 680 690 700
KDIHSDLHAY VQHRVHSSQD ILSNISLNGK ADAALISKVS SHLVLRSLGS
710 720 730 740 750
YLYLKLTLDL FQRGHLVIKS ASYKVVPVSL SELYLLQCNM KFMTQSAFDR
760 770 780 790 800
ALPILNVALA SLHPMTDEQI FQAINAGHIQ GEQGWEDFQQ RMEALSCFLI
810 820 830 840 850
KRRDKTRMFC HPSFREWLVW RADGESTAFL CEPRNGHALL AFMFSRQESK
860 870 880 890 900
LNRQQTMELG HHILKAHIFK GLSKKTGVSS SHLQALWIGY STEGLSAALA
910 920 930 940 950
SLRNLYTPNV KVSRLLILGG ANVNYRTEVL NNAPILCVQS HLGHEEVVTL
960 970 980 990 1000
LLEFGACLDG MSENGMNALC YAAAAGHMKL VCLLIKKGAR VDHLDKKGQC
1010 1020 1030 1040 1050
ALVHSALRGH SDILQYLLNC EWSAGPPQPG TLRKSQALQQ ALTAAASMGH
1060 1070 1080 1090 1100
SSVVQSLLGM AEEHEIEVNG TDTLWGETAL TAAAGRGKVE ICELLLERGA
1110 1120 1130 1140 1150
AVSRANRRGV PPLFCAARQG HWQVVRLLLD RGCDVNLSDK QGRTPLMVAS
1160 1170 1180 1190 1200
CEGHLSTVEF LLSKGAALSS LDKEGLSALS WACLKGHRAV VQYLVEEGAE
1210 1220 1230 1240 1250
IDQTDKNGRT PLDLAAFYGD AETVLYLVEK GAVIEHVDHS GMRPLDRAIG
1260 1270 1280 1290 1300
CRNTAVVVTL LRKGAKLGNA AWAMATSKPD ILIILLQKLV EEGNVMYKKG
1310 1320 1330 1340 1350
KMKEAAQRYQ YALRKFPREG LGEDMRPFNE LRVSLYLNLS RCRRKTNDFG
1360 1370 1380 1390 1400
LAEEFASKAL ELKPKSYEAF YARARAKRNS RQFLAALADL QEAVKLCPNN
1410 1420 1430 1440 1450
QEIKRLLARV EEECKQLQRN QQQKQQGPPP APANDSDNEE DAPASSLKDH
1460 1470 1480 1490 1500
FPIEEAEEED TSSQEESISP TPRSQPPPSV PSPYIRNLQE GLQSKGRSAS
1510 1520 1530 1540 1550
PQSRAGISKS LRETVAQSGL VMQPTKQAQI VKTNQHLGSG QSSMRNSSTK
1560 1570 1580 1590 1600
IQVSSQNPPP SPMPGRVSAA PAVSRNQHLE GTGPFTAGTG CGHFGDRLGA
1610 1620 1630 1640 1650
SQSLQLQRSE SGTAYPLPSK VKAAERLLAH ASVAVDMAPP NQGGPVSCSD
1660 1670 1680 1690 1700
VRHPASLSSS GSSGSPSSSI KMSSSTSSLT SSSSVSDGFK VQGPDSRIRD
1710 1720 1730 1740 1750
KGTTQVQGGT AEHRPRNTPF MGIMDKTARF QQQSNPPNRS WHCPVAEGLL
1760 1770 1780 1790 1800
TNTATAAGLQ SNSEKPTLKP GGYCSQAKPC SVPPLSMGVH NGAQVKELEE
1810 1820 1830 1840 1850
NKCQIPALCQ DNRITKGVPH LYPEGVSKQP LHVSTEAHRS HLTSAKPKRS

FIESNV
Length:1,856
Mass (Da):200,805
Last modified:February 5, 2008 - v2
Checksum:i5CD2DD065C564E33
GO
Isoform 2 (identifier: Q0VGY8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-102: Missing.
     1079-1092: ALTAAAGRGKVEIC → GNYASSVCSQQPRA
     1093-1856: Missing.

Note: No experimental confirmation available.
Show »
Length:990
Mass (Da):107,607
Checksum:i6112BB92165C4846
GO

Sequence cautioni

The sequence CAM27490 differs from that shown. Reason: Erroneous gene model prediction. Curated
The sequence CAM27492 differs from that shown. Reason: Erroneous gene model prediction. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti166 – 1661L → M in BAC26741 (PubMed:16141072).Curated
Sequence conflicti209 – 2091I → N in BAC26741 (PubMed:16141072).Curated
Sequence conflicti1102 – 11021V → L in AAH79914 (PubMed:15489334).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 102102Missing in isoform 2. 1 PublicationVSP_030829Add
BLAST
Alternative sequencei1079 – 109214ALTAA…KVEIC → GNYASSVCSQQPRA in isoform 2. 1 PublicationVSP_030830Add
BLAST
Alternative sequencei1093 – 1856764Missing in isoform 2. 1 PublicationVSP_030831Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK030022 mRNA. Translation: BAC26741.1.
AL929160 Genomic DNA. Translation: CAM27490.1. Sequence problems.
AL929160 Genomic DNA. Translation: CAM27492.1. Sequence problems.
BC079914 mRNA. Translation: AAH79914.1.
BC047437 mRNA. Translation: AAH47437.1.
CCDSiCCDS16054.1. [Q0VGY8-1]
RefSeqiNP_001277588.1. NM_001290659.1.
NP_938036.2. NM_198294.3. [Q0VGY8-1]
UniGeneiMm.27917.

Genome annotation databases

EnsembliENSMUST00000037526; ENSMUSP00000036003; ENSMUSG00000035168. [Q0VGY8-1]
ENSMUST00000139863; ENSMUSP00000123345; ENSMUSG00000035168. [Q0VGY8-1]
GeneIDi66860.
KEGGimmu:66860.
UCSCiuc008jtj.2. mouse. [Q0VGY8-1]
uc008jtk.1. mouse. [Q0VGY8-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK030022 mRNA. Translation: BAC26741.1.
AL929160 Genomic DNA. Translation: CAM27490.1. Sequence problems.
AL929160 Genomic DNA. Translation: CAM27492.1. Sequence problems.
BC079914 mRNA. Translation: AAH79914.1.
BC047437 mRNA. Translation: AAH47437.1.
CCDSiCCDS16054.1. [Q0VGY8-1]
RefSeqiNP_001277588.1. NM_001290659.1.
NP_938036.2. NM_198294.3. [Q0VGY8-1]
UniGeneiMm.27917.

3D structure databases

ProteinModelPortaliQ0VGY8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi211768. 1 interaction.
STRINGi10090.ENSMUSP00000036003.

PTM databases

iPTMnetiQ0VGY8.
PhosphoSiteiQ0VGY8.

Proteomic databases

EPDiQ0VGY8.
MaxQBiQ0VGY8.
PaxDbiQ0VGY8.
PeptideAtlasiQ0VGY8.
PRIDEiQ0VGY8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000037526; ENSMUSP00000036003; ENSMUSG00000035168. [Q0VGY8-1]
ENSMUST00000139863; ENSMUSP00000123345; ENSMUSG00000035168. [Q0VGY8-1]
GeneIDi66860.
KEGGimmu:66860.
UCSCiuc008jtj.2. mouse. [Q0VGY8-1]
uc008jtk.1. mouse. [Q0VGY8-2]

Organism-specific databases

CTDi85461.
MGIiMGI:1914110. Tanc1.

Phylogenomic databases

eggNOGiKOG0504. Eukaryota.
COG0666. LUCA.
GeneTreeiENSGT00840000129677.
HOGENOMiHOG000231045.
HOVERGENiHBG061464.
InParanoidiQ0VGY8.
OMAiEHRPRNT.
OrthoDBiEOG091G00QZ.
PhylomeDBiQ0VGY8.
TreeFamiTF323159.

Miscellaneous databases

ChiTaRSiTanc1. mouse.
PROiQ0VGY8.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000035168.
ExpressionAtlasiQ0VGY8. baseline and differential.
GenevisibleiQ0VGY8. MM.

Family and domain databases

Gene3Di1.25.40.10. 1 hit.
1.25.40.20. 4 hits.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR027417. P-loop_NTPase.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR019734. TPR_repeat.
[Graphical view]
PfamiPF00023. Ank. 1 hit.
PF12796. Ank_2. 3 hits.
[Graphical view]
SMARTiSM00248. ANK. 10 hits.
SM00028. TPR. 3 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
SSF48452. SSF48452. 1 hit.
SSF52540. SSF52540. 2 hits.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 6 hits.
PS50005. TPR. 3 hits.
PS50293. TPR_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTANC1_MOUSE
AccessioniPrimary (citable) accession number: Q0VGY8
Secondary accession number(s): A2AUL4
, A2AUL6, Q80VD2, Q8C0Q6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: February 5, 2008
Last modified: September 7, 2016
This is version 95 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.