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Protein

Protein ZGRF1

Gene

Zgrf1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Names & Taxonomyi

Protein namesi
Recommended name:
Protein ZGRF1
Alternative name(s):
GRF-type zinc finger domain-containing protein 1
Gene namesi
Name:Zgrf1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:1918893. Zgrf1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei1705 – 1725HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002866271 – 1863Protein ZGRF1Add BLAST1863

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei331PhosphoserineCombined sources1
Modified residuei445PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ0VGT4.
PaxDbiQ0VGT4.
PRIDEiQ0VGT4.

PTM databases

iPTMnetiQ0VGT4.
PhosphoSitePlusiQ0VGT4.

Expressioni

Gene expression databases

BgeeiENSMUSG00000051278.
CleanExiMM_4930422G04RIK.
ExpressionAtlasiQ0VGT4. baseline and differential.
GenevisibleiQ0VGT4. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000044432.

Structurei

3D structure databases

SMRiQ0VGT4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1802. Eukaryota.
COG1112. LUCA.
GeneTreeiENSGT00800000124068.
HOVERGENiHBG103782.
InParanoidiQ0VGT4.
OMAiHCLGVSQ.
OrthoDBiEOG091G00H5.
TreeFamiTF317543.

Family and domain databases

InterProiView protein in InterPro
IPR018838. DUF2439.
IPR027417. P-loop_NTPase.
IPR010666. Znf_GRF.
PfamiView protein in Pfam
PF10382. DUF2439. 1 hit.
PF06839. zf-GRF. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q0VGT4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MECQEFIVLY THQKMKKSKV WQDGVLKITH LGNKAILYDD KGACLESLFL
60 70 80 90 100
KCLEVKPGDD LESERYLITV EEAKAVGSRA VEPDGSREAL ESGSRTLVSS
110 120 130 140 150
SRSLGCQPSG LKRKATGFQR PYKMPKKVTI TENSEPAASL GDENPGPPGP
160 170 180 190 200
RLLPTFSSTL PLFPTVGQKD LTPVSTDNQS PITFSNRERS DTPLSLPSSY
210 220 230 240 250
FKINTNTLGK EDKLCFPVSS ETKHSDSLLA SEPMRRNGLD SHCPGVSQNV
260 270 280 290 300
RSKAQILALL KSSSTNRKDL HGEIPGHFPK IEPQGCLNII SKPEEDYAET
310 320 330 340 350
QSIGNLRCEQ QSENPTRTTS RWARYLPSQR SPPCSAADEN DTEDKPEAQE
360 370 380 390 400
DVNIFNLSEL LQKKSELFET CSKKGELHSE DKPVDNTCQY WNQEDNLAPS
410 420 430 440 450
FCKNSSVLVS CSSKENASLL SESDIQYSSK VPVNQHEKVW TREGSQGADA
460 470 480 490 500
DAALEPEYRP VSPLPEIGHK QTEVEASLST SSRISDDIAD MGSKSNADRE
510 520 530 540 550
DLKTVHKAVQ PFLEVSFNLS NFETSDTDEA SQEDSRLSQD SERWEKEAVL
560 570 580 590 600
TDDSCVQKSC EDIGCREIVG KLPLLSSTDD EPKEALPADG TLLSEFCDRT
610 620 630 640 650
CVGFNSGPHG DVKTGKALEG QCHSDTGSSL DSSLEWSEDV AGDSREDASQ
660 670 680 690 700
SIQGNAINCG GVSPSKKPRG VNRSLYSPYL LTAVTDPAPE NSDLLSEARK
710 720 730 740 750
SPAIEVSRAL LECPCEHRAS QQPVEFQGHQ VKGSATSGVM VRGHSLQRGC
760 770 780 790 800
TQFPDSIDYE NFLTDTCVWT PGLPSTYGQT DFLQVISPEQ KIPALSPAPT
810 820 830 840 850
FSFNTRNEDT VLELSEESLK TRTLPGLKTI GFQDSKNLQR FPFLSGASAP
860 870 880 890 900
FATLPADDGP AVLDPCSFMI DDDAREPSGS SMLNLCEESG LSFDLGLEGQ
910 920 930 940 950
GGTPGGVSLL PKSSTQSKWL KYQNPPQCNS TAPNRLASEV TEGLFAEAVS
960 970 980 990 1000
GLHFSHTSES ESSVDPVRLQ MIKGLLHQQQ QDLVSRKQAF SLTLNQTCKT
1010 1020 1030 1040 1050
QEHETVLGSS ASKNCRAKDL QEINNSDLCF PNGQKIISAY LPQRQVHIPA
1060 1070 1080 1090 1100
VFQSPAHYRQ VFTASIIEHL NILLFELAQR LYKALSKVDI SFYTSSKGET
1110 1120 1130 1140 1150
MRSGKNNSPS CHHNQPAKLV MVKKEGPNKG RLFYTCDKSK DNQCKFFKWL
1160 1170 1180 1190 1200
EEVTPGQLPQ NTSQSTMVFN DIKSIGSYLR SQKVPVYEEC QLLLRRGFDF
1210 1220 1230 1240 1250
QRKQCGKLKK LTTVNPDFYS ETKSKIYLKL SRRESSSVYS KGDLWVISKT
1260 1270 1280 1290 1300
LDFELDTFIA CSAFFGPSSV NEVELLPLKG YFPSNWPTNI TVHALLVCNA
1310 1320 1330 1340 1350
STELTTLQNI QDYFNPAALP LMPYLLAMSQ SATVSSKNIS KRKFIPPAIT
1360 1370 1380 1390 1400
SIKTKTELHL GATLQLAREL INVHRLNKDQ ATALIQIAQM MASQGSDEDA
1410 1420 1430 1440 1450
LEPFGHSLPI TVIHGVFGAG KSYLLAVVIL FLVELFEKCD SGTVGNARPW
1460 1470 1480 1490 1500
KVLVSSSTNV AVDRVLLGLL SLGFEKFIRV GSVRKIAKPV LPYSLHAGSD
1510 1520 1530 1540 1550
NESEQLKELN ALLKEELTPI ERVYVRKSIE QHKLGTNRVL LKQVRVVGVT
1560 1570 1580 1590 1600
CAACAFPCLN DLKFPVVVLD ECSQMTEPAS LLPIARFQCE KLILVGDPKQ
1610 1620 1630 1640 1650
LPPTIQGSDA AHENGLEQTL FDRLCLMGHK PVLLRTQYRC HPAISAIAND
1660 1670 1680 1690 1700
LFYEGSLVNG ISERERSPVL EWLPTLCFYN VTGAEQVERE NSFVNVAEAT
1710 1720 1730 1740 1750
FTLKLIQSLM ASGVESCMIG VITLYKSQMY KICNLLSAVD VGHPDVKAVQ
1760 1770 1780 1790 1800
VSTVDAFQGA EKEITILSCV RTRQVGFIDS EKRMNVALTR GRRHLLIVGS
1810 1820 1830 1840 1850
LSCLRKNRLW GRVIQHCEGR EDGLQHASQC EPQLDHLLKD YLEKQAEEKQ
1860
KKKEKEKSKD KSH
Length:1,863
Mass (Da):205,737
Last modified:October 16, 2013 - v2
Checksum:i14D5C95C1FB6727F
GO
Isoform 2 (identifier: Q0VGT4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     698-856: ARKSPAIEVS...ASAPFATLPA → GTQLFILQSH...SRDPDVSPKG
     857-1863: Missing.

Show »
Length:856
Mass (Da):94,240
Checksum:i8268A8C1153AFD55
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_053245698 – 856ARKSP…ATLPA → GTQLFILQSHRDRNDEQVLS PISSSDISGQLLSTTQDHFE CHELEESSTQISSPLFYPMG IKHPIYRDSEAYISESKELG RIRSLPCDHFEVETTQRNQQ SWATSKSSSELSEVINNMSL LKSQSEHSTALGHLTILKKK HAFPHEVPHSRDPDVSPKG in isoform 2. 1 PublicationAdd BLAST159
Alternative sequenceiVSP_053246857 – 1863Missing in isoform 2. 1 PublicationAdd BLAST1007

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC113952 Genomic DNA. No translation available.
AC158308 Genomic DNA. No translation available.
BC085187 mRNA. Translation: AAH85187.1.
CCDSiCCDS51066.1. [Q0VGT4-1]
RefSeqiNP_932114.2. NM_197997.2. [Q0VGT4-1]
UniGeneiMm.274884.
Mm.454006.

Genome annotation databases

EnsembliENSMUST00000043108; ENSMUSP00000044432; ENSMUSG00000051278. [Q0VGT4-1]
ENSMUST00000195955; ENSMUSP00000142886; ENSMUSG00000051278. [Q0VGT4-2]
ENSMUST00000196141; ENSMUSP00000143761; ENSMUSG00000051278. [Q0VGT4-1]
GeneIDi71643.
KEGGimmu:71643.
UCSCiuc008rhe.1. mouse. [Q0VGT4-2]
uc008rhh.2. mouse. [Q0VGT4-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiZGRF1_MOUSE
AccessioniPrimary (citable) accession number: Q0VGT4
Secondary accession number(s): E9Q2K6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: October 16, 2013
Last modified: June 7, 2017
This is version 57 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot