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Q0VGT2

- GLI2_MOUSE

UniProt

Q0VGT2 - GLI2_MOUSE

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Protein

Zinc finger protein GLI2

Gene
Gli2, Thp
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Acts as a transcriptional activator. May play a role during embryogenesis. Binds to the DNA sequence 5'-GAACCACCCA-3' which is part of the TRE-2S regulatory element. Is involved in the smoothened (SHH) signaling pathway.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri417 – 44428C2H2-type 1Add
BLAST
Zinc fingeri455 – 47723C2H2-type 2; degenerateAdd
BLAST
Zinc fingeri483 – 50725C2H2-type 3Add
BLAST
Zinc fingeri513 – 53826C2H2-type 4Add
BLAST
Zinc fingeri544 – 56926C2H2-type 5Add
BLAST

GO - Molecular functioni

  1. chromatin binding Source: MGI
  2. DNA binding Source: MGI
  3. protein binding Source: UniProtKB
  4. sequence-specific DNA binding Source: MGI
  5. sequence-specific DNA binding transcription factor activity Source: MGI
  6. transcription regulatory region DNA binding Source: MGI
  7. zinc ion binding Source: Ensembl

GO - Biological processi

  1. anatomical structure development Source: MGI
  2. anatomical structure formation involved in morphogenesis Source: MGI
  3. axon guidance Source: MGI
  4. branching morphogenesis of an epithelial tube Source: MGI
  5. cell differentiation Source: MGI
  6. cell proliferation Source: MGI
  7. cellular response to organic cyclic compound Source: MGI
  8. cerebellar cortex morphogenesis Source: MGI
  9. chondrocyte differentiation Source: MGI
  10. cochlea morphogenesis Source: MGI
  11. developmental growth Source: MGI
  12. dorsal/ventral neural tube patterning Source: MGI
  13. dorsal/ventral pattern formation Source: MGI
  14. embryonic digestive tract development Source: MGI
  15. embryonic digit morphogenesis Source: MGI
  16. epidermal cell differentiation Source: Ensembl
  17. floor plate formation Source: MGI
  18. head development Source: MGI
  19. heart development Source: MGI
  20. hindbrain development Source: MGI
  21. hindgut morphogenesis Source: MGI
  22. in utero embryonic development Source: MGI
  23. kidney development Source: MGI
  24. lung development Source: MGI
  25. mammary gland development Source: MGI
  26. mammary gland duct morphogenesis Source: MGI
  27. morphogenesis of an epithelium Source: MGI
  28. negative regulation of chondrocyte differentiation Source: MGI
  29. negative regulation of transcription from RNA polymerase II promoter Source: MGI
  30. neural tube development Source: MGI
  31. neuron development Source: MGI
  32. notochord regression Source: MGI
  33. odontogenesis of dentin-containing tooth Source: MGI
  34. osteoblast development Source: MGI
  35. osteoblast differentiation Source: MGI
  36. pattern specification process Source: MGI
  37. pituitary gland development Source: MGI
  38. positive regulation of cell proliferation Source: MGI
  39. positive regulation of DNA replication Source: Ensembl
  40. positive regulation of neuron differentiation Source: MGI
  41. positive regulation of transcription, DNA-templated Source: UniProtKB
  42. positive regulation of transcription from RNA polymerase II promoter Source: MGI
  43. prostatic bud formation Source: MGI
  44. proximal/distal pattern formation Source: MGI
  45. regulation of smoothened signaling pathway Source: MGI
  46. response to mechanical stimulus Source: Ensembl
  47. skeletal system development Source: MGI
  48. smoothened signaling pathway Source: MGI
  49. smoothened signaling pathway involved in dorsal/ventral neural tube patterning Source: MGI
  50. smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation Source: MGI
  51. smoothened signaling pathway involved in spinal cord motor neuron cell fate specification Source: MGI
  52. smoothened signaling pathway involved in ventral spinal cord interneuron specification Source: MGI
  53. spinal cord dorsal/ventral patterning Source: MGI
  54. spinal cord motor neuron differentiation Source: MGI
  55. spinal cord ventral commissure morphogenesis Source: MGI
  56. transcription, DNA-templated Source: UniProtKB-KW
  57. tube development Source: MGI
  58. ventral midline development Source: MGI
  59. ventral spinal cord development Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein GLI2
Alternative name(s):
Tax helper protein
Gene namesi
Name:Gli2
Synonyms:Thp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 1

Organism-specific databases

MGIiMGI:95728. Gli2.

Subcellular locationi

Nucleus 1 Publication

GO - Cellular componenti

  1. ciliary tip Source: MGI
  2. cilium Source: MGI
  3. cytoplasm Source: MGI
  4. membrane Source: MGI
  5. motile primary cilium Source: MGI
  6. nuclear speck Source: MGI
  7. nucleus Source: UniProtKB
  8. primary cilium Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 15441544Zinc finger protein GLI2PRO_0000406215Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei145 – 1451Phosphoserine By similarity
Modified residuei230 – 2301Phosphoserine By similarity
Modified residuei232 – 2321Phosphoserine By similarity
Modified residuei238 – 2381Phosphoserine By similarity
Modified residuei385 – 3851Phosphoserine; by DYRK2 By similarity
Modified residuei707 – 7071Phosphoserine1 Publication
Modified residuei708 – 7081Phosphothreonine1 Publication
Modified residuei740 – 7401N6-acetyllysine; by EP300 By similarity
Modified residuei997 – 9971Phosphoserine; by DYRK2 By similarity

Post-translational modificationi

Phosphorylated in vitro by ULK3. Phosphorylated by DYRK2; this inhibits GLI2 transcription factor activity and promotes proteasomal degradation of GLI2 By similarity.
Acetylation at Lys-740 inhibits Hh target gene expression, probably by impeding entry into chromatin thus preventing promoter occupancy By similarity.

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PRIDEiQ0VGT2.

PTM databases

PhosphoSiteiQ0VGT2.

Expressioni

Gene expression databases

ArrayExpressiQ0VGT2.
BgeeiQ0VGT2.
GenevestigatoriQ0VGT2.

Interactioni

Subunit structurei

Interaction with ZIC1 By similarity.

Binary interactionsi

WithEntry#Exp.IntActNotes
SUFUQ9UMX13EBI-9344284,EBI-740595From a different organism.

Protein-protein interaction databases

BioGridi199943. 13 interactions.
DIPiDIP-60772N.
IntActiQ0VGT2. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ0VGT2.
SMRiQ0VGT2. Positions 416-570.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi789 – 85466Ser-richAdd
BLAST

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri417 – 44428C2H2-type 1Add
BLAST
Zinc fingeri455 – 47723C2H2-type 2; degenerateAdd
BLAST
Zinc fingeri483 – 50725C2H2-type 3Add
BLAST
Zinc fingeri513 – 53826C2H2-type 4Add
BLAST
Zinc fingeri544 – 56926C2H2-type 5Add
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5048.
GeneTreeiENSGT00740000115106.
HOGENOMiHOG000290688.
HOVERGENiHBG005844.
InParanoidiQ0VGT2.
KOiK16798.
OMAiSYPQQSH.
OrthoDBiEOG7X6KZ8.
TreeFamiTF350216.

Family and domain databases

Gene3Di3.30.160.60. 5 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 2 hits.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 5 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 4 hits.
PS50157. ZINC_FINGER_C2H2_2. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q0VGT2-1 [UniParc]FASTAAdd to Basket

« Hide

METSAPAPAL EKKEAKSGLL EDSSFPDPGK KACPLAVAAA VAAHGVPQQL     50
LPAFHAPLPI DMRHQEGRYH YDPHSVHSVH GPPTLSGSPV ISDISLIRLS 100
PHPAGPGESP FSAHHPYVNP HMEHYLRSVH SSPTLSMISA ARGLSPADVA 150
HEHLKERGLF SLAAPGTNPS DYYHQMTLMA SHPTPYGDLL MQSGGAASAP 200
HLHDYLNPVD ASRFSSPRVT PRLSRKRALS ISPLSDASLD LQRMIRTSPN 250
SLVAYINNSR SSSAASGSYG HLSAGALSPA FTFPHPINPV AYQQILSQQR 300
GLGSAFGHTP PLIQPSPTFL AQQPMTLTSI STMPTQLSSS SSNCLNDANQ 350
NKQNSESAVS STVNPITIHK RSKVKTEAEG LRPASPLGLT QEQLADLKED 400
LDRDDCKQEA EVVIYETNCH WADCTKEYDT QEQLVHHINN EHIHGEKKEF 450
VCRWQACTRE QKPFKAQYML VVHMRRHTGE KPHKCTFEGC SKAYSRLENL 500
KTHLRSHTGE KPYVCEHEGC NKAFSNASDR AKHQNRTHSN EKPYICKIPG 550
CTKRYTDPSS LRKHVKTVHG PDAHVTKKQR NDVHVRAPLL KENGDNEASA 600
EPGGRGPEES VEASSTSHTV EDCLHIKAIK TESSGLCQSS PGAQSSCSSE 650
PSPLGSAPNN DSGMEMPGTG PGSLGDLTAL ADTCPGADTS ALAAPSTGGL 700
QLRKHMSTVH RFEQLKREKL KSLKDSCSWA GPAPHTRNTK LPPLPVNGSV 750
LENFNNTGGG GPAGLLPSQR LPELTEVTML SQLQERRDSS TSTMSSAYTV 800
SRRSSGISPY FSSRRSSEAS PLGGLRPHNA SSADSYDPIS TDASRRSSEA 850
SQCSGGGPGL LNLTPAQQYN LRAKYAAATG GPPPTPLPGL DRVSLRTRLA 900
LLDAPERALP GACPHPLGPR RGSDGPTYSH GHGHGYAGAA PAFPHEGPNS 950
STRRASDPVR RPDPLILPRV QRFHSTHNMN PGSLPPCADR RGLHVQSHPS 1000
VDSNLTRNAY SPRPPSINEN VVMEAVAAGV DGPGLECDLG LVEDELVLPD 1050
DVVQYIKAHT GGTLDDGIRQ GYPTEGTGFP ENSKLPSPGL QGHRRLAAAD 1100
SNMGPSAPGL GGCQLSYSPS SNLNKSNMPV QWNEVSSGTV DALPTQVKPP 1150
PFPHSNLAVV QQKPAFGQYP GYNPQSVQSS SGGLDSTQPH LQLRGAPSAS 1200
RGSYTQQPRQ PAAGSQCLGM SAAMSPQASY SQAHPQLSPN IVSGSLNQFS 1250
PSCSNMAAKP SHLGLPQQME VVPNATIMNG HQREHGVPNS SLAAVSQPHP 1300
VLSYPQQDSY QQGSNLLSSH QPGFMESQQN AGFGLMQPRP PLEPNTASRH 1350
RGVRSGQQQL YARTTGQAMV TSANQETAEA MPKGPAGTMV SLAPQPSQDT 1400
GRAQDQNTLY YYGQIHMYEQ NGGCPAVQPQ PPQPQACSDS IQPEPLPSPG 1450
VNQVSSTVDS QLLEPPQIDF DAIMDDGDHS SLFSGALSPT LLHNLSQNSS 1500
RLTTPRNSLT LPSIPAGISN MAVGDMSSML TSLAEESKFL NMMT 1544
Length:1,544
Mass (Da):165,031
Last modified:July 27, 2011 - v2
Checksum:iEA290773B3DE1D6A
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti71 – 711Y → S in AAH85190. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC109271 Genomic DNA. No translation available.
AC122287 Genomic DNA. No translation available.
AC132589 Genomic DNA. No translation available.
BC085190 mRNA. Translation: AAH85190.1.
CCDSiCCDS35692.1.
RefSeqiNP_001074594.1. NM_001081125.1.
XP_006529203.1. XM_006529140.1.
UniGeneiMm.273292.

Genome annotation databases

EnsembliENSMUST00000062483; ENSMUSP00000054837; ENSMUSG00000048402.
GeneIDi14633.
KEGGimmu:14633.
UCSCiuc007cim.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC109271 Genomic DNA. No translation available.
AC122287 Genomic DNA. No translation available.
AC132589 Genomic DNA. No translation available.
BC085190 mRNA. Translation: AAH85190.1 .
CCDSi CCDS35692.1.
RefSeqi NP_001074594.1. NM_001081125.1.
XP_006529203.1. XM_006529140.1.
UniGenei Mm.273292.

3D structure databases

ProteinModelPortali Q0VGT2.
SMRi Q0VGT2. Positions 416-570.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 199943. 13 interactions.
DIPi DIP-60772N.
IntActi Q0VGT2. 1 interaction.

PTM databases

PhosphoSitei Q0VGT2.

Proteomic databases

PRIDEi Q0VGT2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000062483 ; ENSMUSP00000054837 ; ENSMUSG00000048402 .
GeneIDi 14633.
KEGGi mmu:14633.
UCSCi uc007cim.1. mouse.

Organism-specific databases

CTDi 2736.
MGIi MGI:95728. Gli2.

Phylogenomic databases

eggNOGi COG5048.
GeneTreei ENSGT00740000115106.
HOGENOMi HOG000290688.
HOVERGENi HBG005844.
InParanoidi Q0VGT2.
KOi K16798.
OMAi SYPQQSH.
OrthoDBi EOG7X6KZ8.
TreeFami TF350216.

Miscellaneous databases

NextBioi 286486.
PROi Q0VGT2.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q0VGT2.
Bgeei Q0VGT2.
Genevestigatori Q0VGT2.

Family and domain databases

Gene3Di 3.30.160.60. 5 hits.
InterProi IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view ]
Pfami PF00096. zf-C2H2. 2 hits.
[Graphical view ]
SMARTi SM00355. ZnF_C2H2. 5 hits.
[Graphical view ]
PROSITEi PS00028. ZINC_FINGER_C2H2_1. 4 hits.
PS50157. ZINC_FINGER_C2H2_2. 4 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Eye.
  3. "Physical and functional interactions between Zic and Gli proteins."
    Koyabu Y., Nakata K., Mizugishi K., Aruga J., Mikoshiba K.
    J. Biol. Chem. 276:6889-6892(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH ZIC1, SUBCELLULAR LOCATION.
  4. "Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry."
    Sweet S.M., Bailey C.M., Cunningham D.L., Heath J.K., Cooper H.J.
    Mol. Cell. Proteomics 8:904-912(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-707 AND THR-708, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic fibroblast.

Entry informationi

Entry nameiGLI2_MOUSE
AccessioniPrimary (citable) accession number: Q0VGT2
Secondary accession number(s): E9PYJ4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 5, 2011
Last sequence update: July 27, 2011
Last modified: September 3, 2014
This is version 77 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi