Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Ragulator complex protein LAMTOR4

Gene

LAMTOR4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated.1 Publication

GO - Biological processi

  • cell cycle arrest Source: Reactome
  • cellular response to amino acid stimulus Source: UniProtKB
  • macroautophagy Source: Reactome
  • positive regulation of GTPase activity Source: GOC
  • positive regulation of TOR signaling Source: UniProtKB
  • protein localization to lysosome Source: UniProtKB
  • regulation of cell size Source: UniProtKB
Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-HSA-1632852. Macroautophagy.
R-HSA-165159. mTOR signalling.
R-HSA-166208. mTORC1-mediated signalling.
R-HSA-380972. Energy dependent regulation of mTOR by LKB1-AMPK.
R-HSA-5628897. TP53 Regulates Metabolic Genes.

Names & Taxonomyi

Protein namesi
Recommended name:
Ragulator complex protein LAMTOR4
Alternative name(s):
Late endosomal/lysosomal adaptor and MAPK and MTOR activator 4
Cleaved into the following chain:
Gene namesi
Name:LAMTOR4
Synonyms:C7orf59
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:33772. LAMTOR4.

Subcellular locationi

  • Lysosome 1 Publication

GO - Cellular componenti

  • intracellular membrane-bounded organelle Source: HPA
  • lysosomal membrane Source: Reactome
  • lysosome Source: UniProtKB
  • Ragulator complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Lysosome

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162380687.

Polymorphism and mutation databases

BioMutaiLAMTOR4.
DMDMi121940512.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 9999Ragulator complex protein LAMTOR4PRO_0000424498Add
BLAST
Initiator methionineiRemoved; alternateCombined sources
Chaini2 – 9998Ragulator complex protein LAMTOR4, N-terminally processedPRO_0000325841Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineCombined sources
Modified residuei2 – 21N-acetylthreonine; in Ragulator complex protein LAMTOR4, N-terminally processedCombined sources

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ0VGL1.
MaxQBiQ0VGL1.
PaxDbiQ0VGL1.
PeptideAtlasiQ0VGL1.
PRIDEiQ0VGL1.
TopDownProteomicsiQ0VGL1.

PTM databases

iPTMnetiQ0VGL1.
PhosphoSiteiQ0VGL1.

Expressioni

Gene expression databases

BgeeiENSG00000188186.
CleanExiHS_C7orf59.
ExpressionAtlasiQ0VGL1. baseline and differential.
GenevisibleiQ0VGL1. HS.

Organism-specific databases

HPAiHPA020998.

Interactioni

Subunit structurei

Part of the Ragulator complex composed of LAMTOR1, LAMTOR2, LAMTOR3, LAMTOR4 and LAMTOR5. LAMTOR4 and LAMTOR5 form a heterodimer that interacts, through LAMTOR1, with a LAMTOR2, LAMTOR3 heterodimer. The Ragulator complex interacts with both the mTORC1 complex and heterodimers constituted of the Rag GTPases RRAGA, RRAGB, RRAGC and RRAGD; regulated by amino acid availability. The Ragulator complex interacts with SLC38A9; the probable amino acid sensor (PubMed:25561175, PubMed:25567906).3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
LAMTOR5A0A0C4DGV43EBI-5658976,EBI-10173304
LAMTOR5O435043EBI-5658976,EBI-713382
SLC38A9Q8NBW43EBI-5658976,EBI-9978316

Protein-protein interaction databases

BioGridi133178. 14 interactions.
DIPiDIP-61481N.
IntActiQ0VGL1. 16 interactions.
STRINGi9606.ENSP00000343118.

Structurei

3D structure databases

ProteinModelPortaliQ0VGL1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LAMTOR4 family.Curated

Phylogenomic databases

eggNOGiENOG410IZEZ. Eukaryota.
ENOG4112495. LUCA.
GeneTreeiENSGT00390000016053.
HOGENOMiHOG000047533.
HOVERGENiHBG107668.
InParanoidiQ0VGL1.
OMAiMVRTACR.
PhylomeDBiQ0VGL1.
TreeFamiTF324352.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q0VGL1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSALTQGLE RIPDQLGYLV LSEGAVLASS GDLENDEQAA SAISELVSTA
60 70 80 90
CGFRLHRGMN VPFKRLSVVF GEHTLLVTVS GQRVFVVKRQ NRGREPIDV
Length:99
Mass (Da):10,741
Last modified:September 5, 2006 - v1
Checksum:i0FB3D6613F295DEB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH471091 Genomic DNA. Translation: EAW76585.1.
BC063401 mRNA. Translation: AAH63401.1.
BC105609 mRNA. Translation: AAI05610.1.
BC130553 mRNA. Translation: AAI30554.1.
BC130559 mRNA. Translation: AAI30560.1.
CCDSiCCDS34702.1.
RefSeqiNP_001008396.1. NM_001008395.3.
UniGeneiHs.406520.

Genome annotation databases

EnsembliENST00000341942; ENSP00000343118; ENSG00000188186.
GeneIDi389541.
KEGGihsa:389541.
UCSCiuc003utq.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH471091 Genomic DNA. Translation: EAW76585.1.
BC063401 mRNA. Translation: AAH63401.1.
BC105609 mRNA. Translation: AAI05610.1.
BC130553 mRNA. Translation: AAI30554.1.
BC130559 mRNA. Translation: AAI30560.1.
CCDSiCCDS34702.1.
RefSeqiNP_001008396.1. NM_001008395.3.
UniGeneiHs.406520.

3D structure databases

ProteinModelPortaliQ0VGL1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi133178. 14 interactions.
DIPiDIP-61481N.
IntActiQ0VGL1. 16 interactions.
STRINGi9606.ENSP00000343118.

PTM databases

iPTMnetiQ0VGL1.
PhosphoSiteiQ0VGL1.

Polymorphism and mutation databases

BioMutaiLAMTOR4.
DMDMi121940512.

Proteomic databases

EPDiQ0VGL1.
MaxQBiQ0VGL1.
PaxDbiQ0VGL1.
PeptideAtlasiQ0VGL1.
PRIDEiQ0VGL1.
TopDownProteomicsiQ0VGL1.

Protocols and materials databases

DNASUi389541.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000341942; ENSP00000343118; ENSG00000188186.
GeneIDi389541.
KEGGihsa:389541.
UCSCiuc003utq.3. human.

Organism-specific databases

CTDi389541.
GeneCardsiLAMTOR4.
H-InvDBHIX0033651.
HGNCiHGNC:33772. LAMTOR4.
HPAiHPA020998.
neXtProtiNX_Q0VGL1.
PharmGKBiPA162380687.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IZEZ. Eukaryota.
ENOG4112495. LUCA.
GeneTreeiENSGT00390000016053.
HOGENOMiHOG000047533.
HOVERGENiHBG107668.
InParanoidiQ0VGL1.
OMAiMVRTACR.
PhylomeDBiQ0VGL1.
TreeFamiTF324352.

Enzyme and pathway databases

ReactomeiR-HSA-1632852. Macroautophagy.
R-HSA-165159. mTOR signalling.
R-HSA-166208. mTORC1-mediated signalling.
R-HSA-380972. Energy dependent regulation of mTOR by LKB1-AMPK.
R-HSA-5628897. TP53 Regulates Metabolic Genes.

Miscellaneous databases

GenomeRNAii389541.
PROiQ0VGL1.

Gene expression databases

BgeeiENSG00000188186.
CleanExiHS_C7orf59.
ExpressionAtlasiQ0VGL1. baseline and differential.
GenevisibleiQ0VGL1. HS.

Family and domain databases

ProtoNetiSearch...

Entry informationi

Entry nameiLTOR4_HUMAN
AccessioniPrimary (citable) accession number: Q0VGL1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: September 5, 2006
Last modified: September 7, 2016
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.