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Protein

Lysophospholipase D GDPD1

Gene

Gdpd1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Hydrolyzes lysoglycerophospholipids to produce lysophosphatidic acid (LPA) and the corresponding amines. Shows a preference for 1-O-alkyl-sn-glycero-3-phosphocholine (lyso-PAF), lysophosphatidylethanolamine (lyso-PE) and lysophosphatidylcholine (lyso-PC). May be involved in bioactive N-acylethanolamine biosynthesis. Does not display glycerophosphodiester phosphodiesterase activity, since it cannot hydrolyze either glycerophosphoinositol or glycerophosphocholine.By similarity

Catalytic activityi

1-alkyl-sn-glycero-3-phosphoethanolamine + H2O = 1-alkyl-sn-glycerol 3-phosphate + ethanolamine.By similarity
1-acyl-sn-glycero-3-phospho-(N-acyl)-ethanolamine + H2O = 1-acyl-sn-glycero-3-phosphate + N-acylethanolamine.By similarity
1-acyl-sn-glycero-3-phosphoethanolamine + H2O = 1-acyl-sn-glycero-3-phosphate + ethanolamine.By similarity
1-O-(alk-1Z-enyl)-sn-glycero-3-phospho-(N-acyl)-ethanolamine + H2O = 1-O-(1Z-alkenyl)-sn-glycero-3-phosphate + N-acylethanolamine.By similarity
1-acyl-sn-glycero-3-phosphocholine + H2O = 1-acyl-sn-glycero-3-phosphate + choline.By similarity
1-O-alkyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphate + choline.By similarity
1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O 1-hexadecanoyl-sn-glycero-3-phosphate + choline.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi72Divalent metal cationSequence analysis1
Metal bindingi74Divalent metal cationSequence analysis1
Metal bindingi87Divalent metal cationSequence analysis1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
LigandMetal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Lysophospholipase D GDPD1Curated (EC:3.1.4.39By similarity)
Alternative name(s):
Glycerophosphodiester phosphodiesterase 4
Glycerophosphodiester phosphodiesterase domain-containing protein 1
Gene namesi
Name:Gdpd1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1311813. Gdpd1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 3ExtracellularSequence analysis3
Transmembranei4 – 24HelicalSequence analysisAdd BLAST21
Topological domaini25 – 195CytoplasmicSequence analysisAdd BLAST171
Transmembranei196 – 216HelicalSequence analysisAdd BLAST21
Topological domaini217 – 314ExtracellularSequence analysisAdd BLAST98

Keywords - Cellular componenti

Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002519331 – 314Lysophospholipase D GDPD1Add BLAST314

Proteomic databases

PaxDbiQ0VGK4.
PRIDEiQ0VGK4.

PTM databases

iPTMnetiQ0VGK4.
PhosphoSitePlusiQ0VGK4.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000048572.

Structurei

3D structure databases

ProteinModelPortaliQ0VGK4.
SMRiQ0VGK4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini40 – 309GP-PDEAdd BLAST270

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2258. Eukaryota.
COG0584. LUCA.
HOGENOMiHOG000008170.
HOVERGENiHBG054611.
InParanoidiQ0VGK4.
PhylomeDBiQ0VGK4.
TreeFamiTF328545.

Family and domain databases

Gene3Di3.20.20.190. 1 hit.
InterProiView protein in InterPro
IPR030395. GP_PDE_dom.
IPR017946. PLC-like_Pdiesterase_TIM-brl.
PfamiView protein in Pfam
PF03009. GDPD. 1 hit.
SUPFAMiSSF51695. SSF51695. 1 hit.
PROSITEiView protein in PROSITE
PS51704. GP_PDE. 1 hit.

Sequencei

Sequence statusi: Complete.

Q0VGK4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSTAAFCLL STLGGYLVTS FLLLKYPALL HQRKKQRFLS RHISHRGGAG
60 70 80 90 100
ENLENTMAAF QHAVTIGTDM LELDCHITKD EQVVVSHDAN LKRSTGVNVN
110 120 130 140 150
VSDLKYCELP PYLCKLDVPF QRACKCEGTD TRIPLLKEVF EAFPETPINI
160 170 180 190 200
DIKVNNNVLI QKVSELVKQY KREHLTVWGN ASSEIVDKCY KENSDIPILF
210 220 230 240 250
SLQRVLLILG LFFTGLLPFV PIREQFFEIP MPSIILKLKE PHIISKGHKF
260 270 280 290 300
LIWLSDTLLM RKALFDHLTA RGIQVYIWVL NEEHEYKRAF DLGATGVMTD
310
YPTKLKEFLN NMSA
Length:314
Mass (Da):35,811
Last modified:September 5, 2006 - v1
Checksum:iE79B6AA1599F96DD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC105620 mRNA. Translation: AAI05621.1.
RefSeqiNP_001037703.1. NM_001044238.1.
UniGeneiRn.138410.

Genome annotation databases

GeneIDi303407.
KEGGirno:303407.

Similar proteinsi

Entry informationi

Entry nameiGDPD1_RAT
AccessioniPrimary (citable) accession number: Q0VGK4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: September 5, 2006
Last modified: November 22, 2017
This is version 73 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families