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Q0VGK0

- GBRL1_RAT

UniProt

Q0VGK0 - GBRL1_RAT

Protein

Gamma-aminobutyric acid receptor-associated protein-like 1

Gene

Gabarapl1

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Ubiquitin-like modifier that increases cell-surface expression of kappa-type opioid receptor through facilitating anterograde intracellular trafficking of the receptor. Involved in formation of autophagosomal vacuoles. Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation By similarity.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei116 – 1172Cleavage; by ATG4BBy similarity

    GO - Molecular functioni

    1. protein binding Source: RGD

    GO - Biological processi

    1. autophagy Source: UniProtKB-KW

    Keywords - Biological processi

    Autophagy

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Gamma-aminobutyric acid receptor-associated protein-like 1
    Alternative name(s):
    GABA(A) receptor-associated protein-like 1
    Glandular epithelial cell protein 1
    Short name:
    GEC-1
    Gene namesi
    Name:Gabarapl1
    Synonyms:Gec1
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 4

    Organism-specific databases

    RGDi1596143. Gabarapl1.

    Subcellular locationi

    Cytoplasmcytoskeleton 1 Publication. Cytoplasmic vesicle membrane By similarity; Lipid-anchor By similarity. Endoplasmic reticulum 1 Publication. Golgi apparatus 1 Publication. Cytoplasmic vesicleautophagosome By similarity

    GO - Cellular componenti

    1. autophagic vacuole Source: UniProtKB-SubCell
    2. cell body Source: RGD
    3. cytoplasmic vesicle membrane Source: UniProtKB-SubCell
    4. dendrite cytoplasm Source: RGD
    5. dendrite membrane Source: RGD
    6. endoplasmic reticulum Source: RGD
    7. Golgi apparatus Source: RGD
    8. microtubule Source: UniProtKB-KW

    Keywords - Cellular componenti

    Cytoplasm, Cytoplasmic vesicle, Cytoskeleton, Endoplasmic reticulum, Golgi apparatus, Membrane, Microtubule

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 116116Gamma-aminobutyric acid receptor-associated protein-like 1PRO_0000342410Add
    BLAST
    Propeptidei117 – 1171Removed in mature formBy similarityPRO_0000420211

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Lipidationi116 – 1161Phosphatidylethanolamine amidated glycineCurated

    Post-translational modificationi

    The precursor molecule is cleaved by ATG4B to form the cytosolic form, GABARAPL1-I. This is activated by APG7L/ATG7, transferred to ATG3 and conjugated to phospholipid to form the membrane-bound form, GABARAPL1-II By similarity. ATG4B also mediates the delipidation required for GABARAPL1 recycling when autophagosomes fuse with lysosomes By similarity.By similarity

    Keywords - PTMi

    Lipoprotein

    Proteomic databases

    PRIDEiQ0VGK0.

    Expressioni

    Tissue specificityi

    High expression in liver and brain, lower in lung and heart and very low in kidney and skeletal muscle (at protein level). Present in all brain regions and spinal cord (at protein level).1 Publication

    Gene expression databases

    GenevestigatoriQ0VGK0.

    Interactioni

    Subunit structurei

    Interacts with GABRG2 and beta-tubulin. Interacts with ATG13, OPRK1, RB1CC1 and ULK1. Interacts with TP53INP1 and TP53INP2. Directly interacts with SQSTM1. Interacts with ATG3, ATG7 and MAP15. Interacts with TECPR2.By similarity

    Protein-protein interaction databases

    IntActiQ0VGK0. 1 interaction.
    STRINGi10116.ENSRNOP00000011942.

    Structurei

    3D structure databases

    ProteinModelPortaliQ0VGK0.
    SMRiQ0VGK0. Positions 3-111.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 2222Interaction with beta-tubulinBy similarityAdd
    BLAST
    Regioni36 – 6833Interaction with GABRG2By similarityAdd
    BLAST

    Sequence similaritiesi

    Belongs to the ATG8 family.Curated

    Phylogenomic databases

    eggNOGiNOG263746.
    GeneTreeiENSGT00390000012937.
    HOGENOMiHOG000232034.
    HOVERGENiHBG051706.
    InParanoidiQ0VGK0.
    KOiK08341.
    OMAiSRIREKH.
    OrthoDBiEOG70KGRK.
    PhylomeDBiQ0VGK0.
    TreeFamiTF314556.

    Family and domain databases

    InterProiIPR004241. Atg8_like.
    IPR029071. Ubiquitin-rel_dom.
    [Graphical view]
    PANTHERiPTHR10969. PTHR10969. 1 hit.
    PfamiPF02991. Atg8. 1 hit.
    [Graphical view]
    SUPFAMiSSF54236. SSF54236. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q0VGK0-1 [UniParc]FASTAAdd to Basket

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    MKFQYKEDHP FEYRKKEGEK IRKKYPDRVP VIVEKAPKAR VPDLDKRKYL    50
    VPSDLTVGQF YFLIRKRIHL RPEDALFFFV NNTIPPTSAT MGQLYEDNHE 100
    EDYFLYVAYS DESVYGK 117
    Length:117
    Mass (Da):14,044
    Last modified:September 5, 2006 - v1
    Checksum:i7F56E345255F564B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC105627 mRNA. Translation: AAI05628.1.
    RefSeqiNP_001037759.1. NM_001044294.1.
    UniGeneiRn.118264.

    Genome annotation databases

    EnsembliENSRNOT00000011942; ENSRNOP00000011942; ENSRNOG00000008498.
    GeneIDi689161.
    KEGGirno:689161.
    UCSCiRGD:1596143. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC105627 mRNA. Translation: AAI05628.1 .
    RefSeqi NP_001037759.1. NM_001044294.1.
    UniGenei Rn.118264.

    3D structure databases

    ProteinModelPortali Q0VGK0.
    SMRi Q0VGK0. Positions 3-111.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q0VGK0. 1 interaction.
    STRINGi 10116.ENSRNOP00000011942.

    Proteomic databases

    PRIDEi Q0VGK0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000011942 ; ENSRNOP00000011942 ; ENSRNOG00000008498 .
    GeneIDi 689161.
    KEGGi rno:689161.
    UCSCi RGD:1596143. rat.

    Organism-specific databases

    CTDi 23710.
    RGDi 1596143. Gabarapl1.

    Phylogenomic databases

    eggNOGi NOG263746.
    GeneTreei ENSGT00390000012937.
    HOGENOMi HOG000232034.
    HOVERGENi HBG051706.
    InParanoidi Q0VGK0.
    KOi K08341.
    OMAi SRIREKH.
    OrthoDBi EOG70KGRK.
    PhylomeDBi Q0VGK0.
    TreeFami TF314556.

    Miscellaneous databases

    NextBioi 738082.

    Gene expression databases

    Genevestigatori Q0VGK0.

    Family and domain databases

    InterProi IPR004241. Atg8_like.
    IPR029071. Ubiquitin-rel_dom.
    [Graphical view ]
    PANTHERi PTHR10969. PTHR10969. 1 hit.
    Pfami PF02991. Atg8. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54236. SSF54236. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Liver.
    2. Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiGBRL1_RAT
    AccessioniPrimary (citable) accession number: Q0VGK0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 2008
    Last sequence update: September 5, 2006
    Last modified: October 1, 2014
    This is version 66 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3