Q0VGK0 (GBRL1_RAT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Gamma-aminobutyric acid receptor-associated protein-like 1

Alternative name(s):
GABA(A) receptor-associated protein-like 1
Glandular epithelial cell protein 1
Short name=GEC-1

Gene names

Name:	Gabarapl1
Synonyms:	Gec1

Organism

Rattus norvegicus (Rat) [Reference proteome]

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	117 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Increases cell-surface expression of kappa-type opioid receptor through facilitating anterograde intracellular trafficking of the receptor. Involved in formation of autophagosomal vacuoles By similarity.
Subunit structure	Interacts with GABRG2 and beta-tubulin By similarity. Interacts with OPRK1 By similarity. Interacts with TP53INP1 and TP53INP2 By similarity. Directly interacts with SQSTM1 By similarity.
Subcellular location	Cytoplasm › cytoskeleton. Cytoplasmic vesicle membrane; Lipid-anchor By similarity. Endoplasmic reticulum. Golgi apparatus. Cytoplasmic vesicle › autophagosome By similarity Ref.2.
Tissue specificity	High expression in liver and brain, lower in lung and heart and very low in kidney and skeletal muscle (at protein level). Present in all brain regions and spinal cord (at protein level). Ref.2
Post-translational modification	The precursor molecule is cleaved by APG4B/ATG4B. ATG4B also mediates the delipidation required for GABARAPL1 recycling when autophagosomes fuse with lysosomes By similarity.
Sequence similarities	Belongs to the MAP1 LC3 family.

Ontologies

Keywords
Biological process	Autophagy
Cellular component	Cytoplasm Cytoplasmic vesicle Cytoskeleton Endoplasmic reticulum Golgi apparatus Membrane Microtubule
PTM	Lipoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	autophagy Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	Golgi apparatus Inferred from direct assay Ref.2. Source: RGD autophagic vacuole Inferred from electronic annotation. Source: UniProtKB-SubCell cell body Inferred from direct assay Ref.2. Source: RGD cytoplasmic vesicle membrane Inferred from electronic annotation. Source: UniProtKB-SubCell dendrite cytoplasm Inferred from direct assay Ref.2. Source: RGD dendrite membrane Inferred from direct assay Ref.2. Source: RGD endoplasmic reticulum Inferred from direct assay Ref.2. Source: RGD microtubule Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 116	116	Gamma-aminobutyric acid receptor-associated protein-like 1		PRO_0000342410
	Propeptide	117	1	Removed in mature form By similarity		PRO_0000420211
Regions
	Region	1 – 22	22	Interaction with beta-tubulin By similarity
	Region	36 – 68	33	Interaction with GABRG2 By similarity
Amino acid modifications
	Lipidation	116	1	Phosphatidylethanolamine amidated glycine Probable

Sequences

	Sequence		Length	Mass (Da)
	Q0VGK0 [UniParc]. Last modified September 5, 2006. Version 1. Checksum: 7F56E345255F564B	FASTA	117	14,044
	10 20 30 40 50 60 MKFQYKEDHP FEYRKKEGEK IRKKYPDRVP VIVEKAPKAR VPDLDKRKYL VPSDLTVGQF 70 80 90 100 110 YFLIRKRIHL RPEDALFFFV NNTIPPTSAT MGQLYEDNHE EDYFLYVAYS DESVYGK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Liver.
[2]	"Distribution and ultrastructural localization of GEC1 in the rat CNS." Wang Y., Dun S.L., Huang P., Chen C., Chen Y., Unterwald E.M., Dun N.J., Van Bockstaele E.J., Liu-Chen L.-Y. Neuroscience 140:1265-1276(2006) [PubMed] [Europe PMC] [Abstract] Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC105627 mRNA. Translation: AAI05628.1.
IPI	IPI00203882.
RefSeq	NP_001037759.1. NM_001044294.1.
UniGene	Rn.118264.
3D structure databases
ProteinModelPortal	Q0VGK0.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q0VGK0. 1 interaction.
STRING	10116.ENSRNOP00000011942.
Proteomic databases
PRIDE	Q0VGK0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSRNOT00000011942; ENSRNOP00000011942; ENSRNOG00000008498.
GeneID	689161.
KEGG	rno:689161.
UCSC	RGD:1596143. rat.
Organism-specific databases
CTD	23710.
RGD	1596143. Gabarapl1.
Phylogenomic databases
eggNOG	NOG263746.
GeneTree	ENSGT00390000012937.
HOGENOM	HOG000232034.
HOVERGEN	HBG051706.
InParanoid	Q0VGK0.
KO	K08341.
OrthoDB	EOG4T4CWW.
Gene expression databases
Genevestigator	Q0VGK0.
Family and domain databases
InterPro	IPR004241. Atg8_ubiquitin-like. [Graphical view]
PANTHER	PTHR10969. PTHR10969. 1 hit.
Pfam	PF02991. Atg8. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	738082.

Entry information

Entry name

GBRL1_RAT

Accession

Primary (citable) accession number: Q0VGK0

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 1, 2008
Last sequence update:	September 5, 2006
Last modified:	May 1, 2013
This is version 55 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program