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Q0VGK0

- GBRL1_RAT

UniProt

Q0VGK0 - GBRL1_RAT

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Protein

Gamma-aminobutyric acid receptor-associated protein-like 1

Gene
Gabarapl1, Gec1
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Ubiquitin-like modifier that increases cell-surface expression of kappa-type opioid receptor through facilitating anterograde intracellular trafficking of the receptor. Involved in formation of autophagosomal vacuoles. Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei116 – 1172Cleavage; by ATG4B By similarity

GO - Molecular functioni

  1. GABA receptor binding Source: RefGenome
  2. microtubule binding Source: RefGenome
  3. phosphatidylethanolamine binding Source: RefGenome
  4. protein binding Source: RGD

GO - Biological processi

  1. autophagic vacuole assembly Source: RefGenome
  2. CVT pathway Source: RefGenome
  3. late nucleophagy Source: RefGenome
  4. mitochondrion degradation Source: RefGenome
  5. piecemeal microautophagy of nucleus Source: RefGenome
  6. programmed cell death Source: RefGenome
  7. protein targeting to vacuole involved in autophagy Source: RefGenome
Complete GO annotation...

Keywords - Biological processi

Autophagy

Names & Taxonomyi

Protein namesi
Recommended name:
Gamma-aminobutyric acid receptor-associated protein-like 1
Alternative name(s):
GABA(A) receptor-associated protein-like 1
Glandular epithelial cell protein 1
Short name:
GEC-1
Gene namesi
Name:Gabarapl1
Synonyms:Gec1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 4

Organism-specific databases

RGDi1596143. Gabarapl1.

Subcellular locationi

Cytoplasmcytoskeleton. Cytoplasmic vesicle membrane; Lipid-anchor By similarity. Endoplasmic reticulum. Golgi apparatus. Cytoplasmic vesicleautophagosome By similarity 1 Publication

GO - Cellular componenti

  1. autophagic vacuole membrane Source: RefGenome
  2. cell body Source: RGD
  3. cytoplasmic vesicle membrane Source: UniProtKB-SubCell
  4. cytosol Source: RefGenome
  5. dendrite cytoplasm Source: RGD
  6. dendrite membrane Source: RGD
  7. endoplasmic reticulum Source: RGD
  8. Golgi apparatus Source: RGD
  9. microtubule Source: UniProtKB-KW
  10. pre-autophagosomal structure Source: RefGenome
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoplasmic vesicle, Cytoskeleton, Endoplasmic reticulum, Golgi apparatus, Membrane, Microtubule

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 116116Gamma-aminobutyric acid receptor-associated protein-like 1PRO_0000342410Add
BLAST
Propeptidei117 – 1171Removed in mature form By similarityPRO_0000420211

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi116 – 1161Phosphatidylethanolamine amidated glycine Inferred

Post-translational modificationi

The precursor molecule is cleaved by ATG4B to form the cytosolic form, GABARAPL1-I. This is activated by APG7L/ATG7, transferred to ATG3 and conjugated to phospholipid to form the membrane-bound form, GABARAPL1-II By similarity. ATG4B also mediates the delipidation required for GABARAPL1 recycling when autophagosomes fuse with lysosomes By similarity.

Keywords - PTMi

Lipoprotein

Proteomic databases

PRIDEiQ0VGK0.

Expressioni

Tissue specificityi

High expression in liver and brain, lower in lung and heart and very low in kidney and skeletal muscle (at protein level). Present in all brain regions and spinal cord (at protein level).1 Publication

Gene expression databases

GenevestigatoriQ0VGK0.

Interactioni

Subunit structurei

Interacts with GABRG2 and beta-tubulin By similarity. Interacts with ATG13, OPRK1, RB1CC1 and ULK1 By similarity. Interacts with TP53INP1 and TP53INP2 By similarity. Directly interacts with SQSTM1 By similarity. Interacts with ATG3, ATG7 and MAP15 By similarity. Interacts with TECPR2 By similarity.

Protein-protein interaction databases

IntActiQ0VGK0. 1 interaction.
STRINGi10116.ENSRNOP00000011942.

Structurei

3D structure databases

ProteinModelPortaliQ0VGK0.
SMRiQ0VGK0. Positions 3-111.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 2222Interaction with beta-tubulin By similarityAdd
BLAST
Regioni36 – 6833Interaction with GABRG2 By similarityAdd
BLAST

Sequence similaritiesi

Belongs to the ATG8 family.

Phylogenomic databases

eggNOGiNOG263746.
GeneTreeiENSGT00390000012937.
HOGENOMiHOG000232034.
HOVERGENiHBG051706.
InParanoidiQ0VGK0.
KOiK08341.
OMAiSRIREKH.
OrthoDBiEOG70KGRK.
PhylomeDBiQ0VGK0.
TreeFamiTF314556.

Family and domain databases

InterProiIPR004241. Atg8_like.
IPR029071. Ubiquitin-rel_dom.
[Graphical view]
PANTHERiPTHR10969. PTHR10969. 1 hit.
PfamiPF02991. Atg8. 1 hit.
[Graphical view]
SUPFAMiSSF54236. SSF54236. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q0VGK0-1 [UniParc]FASTAAdd to Basket

« Hide

MKFQYKEDHP FEYRKKEGEK IRKKYPDRVP VIVEKAPKAR VPDLDKRKYL    50
VPSDLTVGQF YFLIRKRIHL RPEDALFFFV NNTIPPTSAT MGQLYEDNHE 100
EDYFLYVAYS DESVYGK 117
Length:117
Mass (Da):14,044
Last modified:September 5, 2006 - v1
Checksum:i7F56E345255F564B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC105627 mRNA. Translation: AAI05628.1.
RefSeqiNP_001037759.1. NM_001044294.1.
UniGeneiRn.118264.

Genome annotation databases

EnsembliENSRNOT00000011942; ENSRNOP00000011942; ENSRNOG00000008498.
GeneIDi689161.
KEGGirno:689161.
UCSCiRGD:1596143. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC105627 mRNA. Translation: AAI05628.1 .
RefSeqi NP_001037759.1. NM_001044294.1.
UniGenei Rn.118264.

3D structure databases

ProteinModelPortali Q0VGK0.
SMRi Q0VGK0. Positions 3-111.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q0VGK0. 1 interaction.
STRINGi 10116.ENSRNOP00000011942.

Proteomic databases

PRIDEi Q0VGK0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000011942 ; ENSRNOP00000011942 ; ENSRNOG00000008498 .
GeneIDi 689161.
KEGGi rno:689161.
UCSCi RGD:1596143. rat.

Organism-specific databases

CTDi 23710.
RGDi 1596143. Gabarapl1.

Phylogenomic databases

eggNOGi NOG263746.
GeneTreei ENSGT00390000012937.
HOGENOMi HOG000232034.
HOVERGENi HBG051706.
InParanoidi Q0VGK0.
KOi K08341.
OMAi SRIREKH.
OrthoDBi EOG70KGRK.
PhylomeDBi Q0VGK0.
TreeFami TF314556.

Miscellaneous databases

NextBioi 738082.

Gene expression databases

Genevestigatori Q0VGK0.

Family and domain databases

InterProi IPR004241. Atg8_like.
IPR029071. Ubiquitin-rel_dom.
[Graphical view ]
PANTHERi PTHR10969. PTHR10969. 1 hit.
Pfami PF02991. Atg8. 1 hit.
[Graphical view ]
SUPFAMi SSF54236. SSF54236. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Liver.
  2. Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY.

Entry informationi

Entry nameiGBRL1_RAT
AccessioniPrimary (citable) accession number: Q0VGK0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 2008
Last sequence update: September 5, 2006
Last modified: September 3, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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