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Q0VGJ1 (Q0VGJ1_MOUSE) Unreviewed, UniProtKB/TrEMBL

Last modified May 14, 2014. Version 76. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein names
Gene names
Name:Hey2 EMBL AAI05653.1 MGI 1341884
ORF Names:mCG_15061 EMBL EDL04855.1
OrganismMus musculus (Mouse) EMBL AAI05653.1
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length339 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Subcellular location

Nucleus By similarity SAAS SAAS003650.

Sequence similarities

Contains 1 basic helix-loop-helix (bHLH) domain. RuleBase RU000367

Contains Orange domain. SAAS SAAS003650

Contains bHLH (basic helix-loop-helix) domain. SAAS SAAS003650

Ontologies

Keywords
   Biological processTranscription
Transcription regulation SAAS SAAS003650
   Cellular componentNucleus SAAS SAAS003650
Gene Ontology (GO)
   Biological_processNotch signaling pathway

Inferred from electronic annotation. Source: Ensembl

anterior/posterior axis specification

Inferred from genetic interaction PubMed 15680351. Source: MGI

artery development

Inferred from genetic interaction PubMed 15680351. Source: MGI

atrioventricular valve development

Inferred from mutant phenotype PubMed 15297376. Source: MGI

blood vessel development

Inferred from genetic interaction PubMed 15680351. Source: MGI

cardiac muscle hypertrophy

Inferred from mutant phenotype PubMed 20382855. Source: MGI

cardiac muscle hypertrophy in response to stress

Inferred from direct assay PubMed 16603706. Source: MGI

cardiac vascular smooth muscle cell development

Inferred from mutant phenotype PubMed 20619341. Source: MGI

cell fate commitment

Inferred from mutant phenotype PubMed 19154718. Source: MGI

cochlea development

Inferred from mutant phenotype PubMed 18302773. Source: MGI

coronary vasculature morphogenesis

Inferred from mutant phenotype PubMed 20619341. Source: MGI

endocardial cushion to mesenchymal transition involved in heart valve formation

Inferred from genetic interaction PubMed 15680351. Source: MGI

negative regulation of cardiac muscle cell apoptotic process

Inferred from mutant phenotype PubMed 20382855. Source: MGI

negative regulation of gene expression

Inferred from mutant phenotype PubMed 20382855PubMed 22615585. Source: MGI

negative regulation of transcription from RNA polymerase II promoter

Inferred from direct assay PubMed 10692439. Source: MGI

negative regulation of transcription initiation from RNA polymerase II promoter

Inferred from electronic annotation. Source: Ensembl

pattern specification process

Inferred from mutant phenotype PubMed 18302773. Source: MGI

positive regulation of cardiac muscle cell proliferation

Inferred from mutant phenotype PubMed 17332425. Source: MGI

positive regulation of heart rate

Inferred from mutant phenotype PubMed 15297376. Source: MGI

protein-DNA complex assembly

Inferred from direct assay PubMed 10692439PubMed 16603706. Source: MGI

regulation of auditory receptor cell differentiation

Inferred from genetic interaction PubMed 19154718. Source: MGI

regulation of gene expression

Inferred from mutant phenotype PubMed 20619341. Source: MGI

regulation of transcription from RNA polymerase II promoter

Inferred from sequence or structural similarity PubMed 10588864. Source: MGI

transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

tricuspid valve formation

Inferred from mutant phenotype PubMed 15297376. Source: MGI

vasculogenesis

Inferred from genetic interaction PubMed 15107403. Source: MGI

ventricular trabecula myocardium morphogenesis

Inferred from genetic interaction PubMed 15680351. Source: MGI

   Cellular_componentSin3 complex

Inferred from electronic annotation. Source: Ensembl

transcription factor complex

Inferred from sequence or structural similarity PubMed 10588864. Source: MGI

transcriptional repressor complex

Inferred from electronic annotation. Source: Ensembl

   Molecular_functionsequence-specific DNA binding

Inferred from direct assay PubMed 22615585. Source: MGI

sequence-specific DNA binding transcription factor activity

Inferred from sequence or structural similarity PubMed 10860664. Source: MGI

transcription factor binding

Inferred from physical interaction PubMed 16603706. Source: MGI

Complete GO annotation...

Sequences

Sequence LengthMass (Da)Tools
Q0VGJ1 [UniParc].

Last modified September 5, 2006. Version 1.
Checksum: 105BEEA06DE50444

FASTA33935,873
        10         20         30         40         50         60 
MKRPCEETTS ESDLDETIDV GSENNYPGHA TSSVMRSNSP TTTSQIMARK KRRGIIEKRR 

        70         80         90        100        110        120 
RDRINNSLSE LRRLVPTAFE KQGSAKLEKA EILQMTVDHL KMLQATGGKG YFDAHALATD 

       130        140        150        160        170        180 
FMSIGFRECL TEVARYLSSV EGLDPSDPLR VRLVSHLSTC ASQREAAVMT SSMAHHHHPL 

       190        200        210        220        230        240 
HPHHWAAAFH HLPTALLQPN GLHTSESTPC RLSTSSEVPS AHGSALLTAT FAHADSALRM 

       250        260        270        280        290        300 
PSGGTVAPCV PPLSTSLLSL SATVHAAAAA ATAAAHSFPL SFAGAFPMLP SNAAAAAAVA 

       310        320        330 
AATAISPPLS VSAASSPQQT STGTNNKPYQ PWGTEVGAF 

« Hide

References

« Hide 'large scale' references
[1]"A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome."
Mural R.J., Adams M.D., Myers E.W., Smith H.O., Miklos G.L., Wides R., Halpern A., Li P.W., Sutton G.G., Nadeau J., Salzberg S.L., Holt R.A., Kodira C.D., Lu F., Chen L., Deng Z., Evangelista C.C., Gan W. expand/collapse author list , Heiman T.J., Li J., Li Z., Merkulov G.V., Milshina N.V., Naik A.K., Qi R., Shue B.C., Wang A., Wang J., Wang X., Yan X., Ye J., Yooseph S., Zhao Q., Zheng L., Zhu S.C., Biddick K., Bolanos R., Delcher A.L., Dew I.M., Fasulo D., Flanigan M.J., Huson D.H., Kravitz S.A., Miller J.R., Mobarry C.M., Reinert K., Remington K.A., Zhang Q., Zheng X.H., Nusskern D.R., Lai Z., Lei Y., Zhong W., Yao A., Guan P., Ji R.R., Gu Z., Wang Z.Y., Zhong F., Xiao C., Chiang C.C., Yandell M., Wortman J.R., Amanatides P.G., Hladun S.L., Pratts E.C., Johnson J.E., Dodson K.L., Woodford K.J., Evans C.A., Gropman B., Rusch D.B., Venter E., Wang M., Smith T.J., Houck J.T., Tompkins D.E., Haynes C., Jacob D., Chin S.H., Allen D.R., Dahlke C.E., Sanders R., Li K., Liu X., Levitsky A.A., Majoros W.H., Chen Q., Xia A.C., Lopez J.R., Donnelly M.T., Newman M.H., Glodek A., Kraft C.L., Nodell M., Ali F., An H.J., Baldwin-Pitts D., Beeson K.Y., Cai S., Carnes M., Carver A., Caulk P.M., Center A., Chen Y.H., Cheng M.L., Coyne M.D., Crowder M., Danaher S., Davenport L.B., Desilets R., Dietz S.M., Doup L., Dullaghan P., Ferriera S., Fosler C.R., Gire H.C., Gluecksmann A., Gocayne J.D., Gray J., Hart B., Haynes J., Hoover J., Howland T., Ibegwam C., Jalali M., Johns D., Kline L., Ma D.S., MacCawley S., Magoon A., Mann F., May D., McIntosh T.C., Mehta S., Moy L., Moy M.C., Murphy B.J., Murphy S.D., Nelson K.A., Nuri Z., Parker K.A., Prudhomme A.C., Puri V.N., Qureshi H., Raley J.C., Reardon M.S., Regier M.A., Rogers Y.H., Romblad D.L., Schutz J., Scott J.L., Scott R., Sitter C.D., Smallwood M., Sprague A.C., Stewart E., Strong R.V., Suh E., Sylvester K., Thomas R., Tint N.N., Tsonis C., Wang G., Wang G., Williams M.S., Williams S.M., Windsor S.M., Wolfe K., Wu M.M., Zaveri J., Chaturvedi K., Gabrielian A.E., Ke Z., Sun J., Subramanian G., Venter J.C., Pfannkoch C.M., Barnstead M., Stephenson L.D.
Science 296:1661-1671(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: Mixed EMBL EDL04855.1.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M. expand/collapse author list , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: PCR rescued clones EMBL AAI05653.1.
[3]Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: Mixed EMBL EDL04855.1.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC105651 mRNA. Translation: AAI05652.1.
BC105652 mRNA. Translation: AAI05653.1.
CH466540 Genomic DNA. Translation: EDL04855.1.
RefSeqNP_038932.1. NM_013904.1.
UniGeneMm.103573.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID15214.
KEGGmmu:15214.

Organism-specific databases

CTD23493.
MGIMGI:1341884. Hey2.

Phylogenomic databases

HOVERGENHBG003275.
InParanoidQ0VGJ1.
KOK09091.
OMASTCASQR.

Gene expression databases

GenevestigatorQ0VGJ1.

Family and domain databases

Gene3D4.10.280.10. 1 hit.
InterProIPR011598. bHLH_dom.
IPR003650. Orange.
IPR018352. Orange_subgr.
[Graphical view]
PfamPF07527. Hairy_orange. 1 hit.
PF00010. HLH. 1 hit.
[Graphical view]
SMARTSM00353. HLH. 1 hit.
SM00511. ORANGE. 1 hit.
[Graphical view]
SUPFAMSSF47459. SSF47459. 1 hit.
PROSITEPS50888. BHLH. 1 hit.
PS51054. ORANGE. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio287789.
SOURCESearch...

Entry information

Entry nameQ0VGJ1_MOUSE
AccessionPrimary (citable) accession number: Q0VGJ1
Entry history
Integrated into UniProtKB/TrEMBL: September 5, 2006
Last sequence update: September 5, 2006
Last modified: May 14, 2014
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)