Q0VGJ1 (Q0VGJ1_MOUSE) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Hairy/enhancer-of-split related with YRPW motif 2 EMBL AAI05653.1

Gene names

Name:	Hey2 EMBL EDL04855.1 MGI 1341884
ORF Names:	mCG_15061 EMBL EDL04855.1

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	339 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities

Contains 1 Orange domain. SAAS SAAS003650 Contains 1 bHLH (basic helix-loop-helix) domain. SAAS SAAS003650 Contains 1 basic helix-loop-helix (bHLH) domain. RuleBase RU000367

Ontologies

Keywords
Biological process	Transcription Transcription regulation SAAS SAAS003650
Cellular component	Nucleus SAAS SAAS003650
Gene Ontology (GO)
Biological_process	anterior/posterior axis specification Inferred from genetic interaction PubMed 15680351. Source: MGI artery development Inferred from genetic interaction PubMed 15680351. Source: MGI atrioventricular valve development Inferred from mutant phenotype PubMed 15297376. Source: MGI cardiac muscle hypertrophy in response to stress Inferred from direct assay PubMed 16603706. Source: MGI cardiac vascular smooth muscle cell development Inferred from mutant phenotype PubMed 20619341. Source: MGI cell fate commitment Inferred from mutant phenotype PubMed 19154718. Source: MGI cochlea development Inferred from mutant phenotype PubMed 18302773. Source: MGI coronary vasculature morphogenesis Inferred from mutant phenotype PubMed 20619341. Source: MGI endocardial cushion to mesenchymal transition involved in heart valve formation Inferred from genetic interaction PubMed 15680351. Source: MGI negative regulation of cardiac muscle cell apoptotic process Inferred from mutant phenotype PubMed 20382855. Source: MGI negative regulation of transcription from RNA polymerase II promoter Inferred from direct assay PubMed 10692439. Source: MGI negative regulation of transcription initiation from RNA polymerase II promoter Inferred from electronic annotation. Source: Compara negative regulation of transcription regulatory region DNA binding Inferred from electronic annotation. Source: Compara positive regulation of cardiac muscle cell proliferation Inferred from mutant phenotype PubMed 17332425. Source: MGI positive regulation of heart rate Inferred from mutant phenotype PubMed 15297376. Source: MGI protein-DNA complex assembly Inferred from direct assay PubMed 10692439PubMed 16603706. Source: MGI regulation of auditory receptor cell differentiation Inferred from genetic interaction PubMed 19154718. Source: MGI transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW tricuspid valve formation Inferred from mutant phenotype PubMed 15297376. Source: MGI vasculogenesis Inferred from genetic interaction PubMed 15107403. Source: MGI ventricular trabecula myocardium morphogenesis Inferred from genetic interaction PubMed 15680351. Source: MGI
Cellular_component	Sin3 complex Inferred from electronic annotation. Source: Compara transcription factor complex Inferred from sequence or structural similarity PubMed 10588864. Source: MGI transcriptional repressor complex Inferred from electronic annotation. Source: Compara
Molecular_function	microsatellite binding Inferred from electronic annotation. Source: Compara protein binding transcription factor activity Inferred from electronic annotation. Source: Compara sequence-specific DNA binding Inferred from direct assay PubMed 22615585. Source: MGI sequence-specific DNA binding transcription factor activity Inferred from sequence or structural similarity PubMed 10860664. Source: MGI
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q0VGJ1 [UniParc]. Last modified September 5, 2006. Version 1. Checksum: 105BEEA06DE50444	FASTA	339	35,873
	10 20 30 40 50 60 MKRPCEETTS ESDLDETIDV GSENNYPGHA TSSVMRSNSP TTTSQIMARK KRRGIIEKRR 70 80 90 100 110 120 RDRINNSLSE LRRLVPTAFE KQGSAKLEKA EILQMTVDHL KMLQATGGKG YFDAHALATD 130 140 150 160 170 180 FMSIGFRECL TEVARYLSSV EGLDPSDPLR VRLVSHLSTC ASQREAAVMT SSMAHHHHPL 190 200 210 220 230 240 HPHHWAAAFH HLPTALLQPN GLHTSESTPC RLSTSSEVPS AHGSALLTAT FAHADSALRM 250 260 270 280 290 300 PSGGTVAPCV PPLSTSLLSL SATVHAAAAA ATAAAHSFPL SFAGAFPMLP SNAAAAAAVA 310 320 330 AATAISPPLS VSAASSPQQT STGTNNKPYQ PWGTEVGAF

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome." Mural R.J., Adams M.D., Myers E.W., Smith H.O., Miklos G.L., Wides R., Halpern A., Li P.W., Sutton G.G., Nadeau J., Salzberg S.L., Holt R.A., Kodira C.D., Lu F., Chen L., Deng Z., Evangelista C.C., Gan W. , Heiman T.J., Li J., Li Z., Merkulov G.V., Milshina N.V., Naik A.K., Qi R., Shue B.C., Wang A., Wang J., Wang X., Yan X., Ye J., Yooseph S., Zhao Q., Zheng L., Zhu S.C., Biddick K., Bolanos R., Delcher A.L., Dew I.M., Fasulo D., Flanigan M.J., Huson D.H., Kravitz S.A., Miller J.R., Mobarry C.M., Reinert K., Remington K.A., Zhang Q., Zheng X.H., Nusskern D.R., Lai Z., Lei Y., Zhong W., Yao A., Guan P., Ji R.R., Gu Z., Wang Z.Y., Zhong F., Xiao C., Chiang C.C., Yandell M., Wortman J.R., Amanatides P.G., Hladun S.L., Pratts E.C., Johnson J.E., Dodson K.L., Woodford K.J., Evans C.A., Gropman B., Rusch D.B., Venter E., Wang M., Smith T.J., Houck J.T., Tompkins D.E., Haynes C., Jacob D., Chin S.H., Allen D.R., Dahlke C.E., Sanders R., Li K., Liu X., Levitsky A.A., Majoros W.H., Chen Q., Xia A.C., Lopez J.R., Donnelly M.T., Newman M.H., Glodek A., Kraft C.L., Nodell M., Ali F., An H.J., Baldwin-Pitts D., Beeson K.Y., Cai S., Carnes M., Carver A., Caulk P.M., Center A., Chen Y.H., Cheng M.L., Coyne M.D., Crowder M., Danaher S., Davenport L.B., Desilets R., Dietz S.M., Doup L., Dullaghan P., Ferriera S., Fosler C.R., Gire H.C., Gluecksmann A., Gocayne J.D., Gray J., Hart B., Haynes J., Hoover J., Howland T., Ibegwam C., Jalali M., Johns D., Kline L., Ma D.S., MacCawley S., Magoon A., Mann F., May D., McIntosh T.C., Mehta S., Moy L., Moy M.C., Murphy B.J., Murphy S.D., Nelson K.A., Nuri Z., Parker K.A., Prudhomme A.C., Puri V.N., Qureshi H., Raley J.C., Reardon M.S., Regier M.A., Rogers Y.H., Romblad D.L., Schutz J., Scott J.L., Scott R., Sitter C.D., Smallwood M., Sprague A.C., Stewart E., Strong R.V., Suh E., Sylvester K., Thomas R., Tint N.N., Tsonis C., Wang G., Wang G., Williams M.S., Williams S.M., Windsor S.M., Wolfe K., Wu M.M., Zaveri J., Chaturvedi K., Gabrielian A.E., Ke Z., Sun J., Subramanian G., Venter J.C., Pfannkoch C.M., Barnstead M., Stephenson L.D. Science 296:1661-1671(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: Mixed EMBL EDL04855.1.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M. , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J. Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: PCR rescued clones EMBL AAI05653.1.
[3]	Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: Mixed EMBL EDL04855.1.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC105651 mRNA. Translation: AAI05652.1. BC105652 mRNA. Translation: AAI05653.1. CH466540 Genomic DNA. Translation: EDL04855.1.
IPI	IPI00132126.
RefSeq	NP_038932.1. NM_013904.1.
UniGene	Mm.103573.
3D structure databases
SMR	Q0VGJ1. Positions 56-107, 110-164.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	15214.
KEGG	mmu:15214.
UCSC	uc007etp.1. mouse.
Organism-specific databases
CTD	23493.
MGI	MGI:1341884. Hey2.
Phylogenomic databases
HOVERGEN	HBG003275.
InParanoid	Q0VGJ1.
KO	K09091.
OMA	TCASQRE.
Gene expression databases
Genevestigator	Q0VGJ1.
Family and domain databases
Gene3D	4.10.280.10. 1 hit.
InterPro	IPR011598. bHLH_dom. IPR003650. Orange. IPR018352. Orange_subgr. [Graphical view]
Pfam	PF07527. Hairy_orange. 1 hit. PF00010. HLH. 1 hit. [Graphical view]
SMART	SM00353. HLH. 1 hit. SM00511. ORANGE. 1 hit. [Graphical view]
SUPFAM	SSF47459. HLH_basic. 1 hit.
PROSITE	PS50888. BHLH. 1 hit. PS51054. ORANGE. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	287789.
SOURCE	Search...

Entry information

Entry name

Q0VGJ1_MOUSE

Accession

Primary (citable) accession number: Q0VGJ1

Entry history

Integrated into UniProtKB/TrEMBL:	September 5, 2006
Last sequence update:	September 5, 2006
Last modified:	May 1, 2013
This is version 67 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)