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Protein

Zinc finger protein 816

Gene

ZNF816

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri227 – 251C2H2-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri257 – 279C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri285 – 307C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri313 – 335C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri341 – 363C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri369 – 391C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri397 – 419C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri425 – 447C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri453 – 475C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri481 – 503C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri509 – 531C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri537 – 559C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri565 – 587C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri593 – 615C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri621 – 643C2H2-type 15PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 816
Gene namesi
Name:ZNF816
Synonyms:ZNF816A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000180257.13
HGNCiHGNC:26995 ZNF816
neXtProtiNX_Q0VGE8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi125893
OpenTargetsiENSG00000180257
PharmGKBiPA165394953

Polymorphism and mutation databases

BioMutaiZNF816
DMDMi290457609

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002943621 – 651Zinc finger protein 816Add BLAST651

Proteomic databases

EPDiQ0VGE8
MaxQBiQ0VGE8
PaxDbiQ0VGE8
PeptideAtlasiQ0VGE8
PRIDEiQ0VGE8

PTM databases

iPTMnetiQ0VGE8
PhosphoSitePlusiQ0VGE8

Expressioni

Gene expression databases

BgeeiENSG00000180257
CleanExiHS_ZNF816A
ExpressionAtlasiQ0VGE8 baseline and differential
GenevisibleiQ0VGE8 HS

Organism-specific databases

HPAiHPA042466

Interactioni

Protein-protein interaction databases

BioGridi125933, 14 interactors
STRINGi9606.ENSP00000350295

Structurei

3D structure databases

ProteinModelPortaliQ0VGE8
SMRiQ0VGE8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini24 – 98KRABPROSITE-ProRule annotationAdd BLAST75

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri227 – 251C2H2-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri257 – 279C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri285 – 307C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri313 – 335C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri341 – 363C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri369 – 391C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri397 – 419C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri425 – 447C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri453 – 475C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri481 – 503C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri509 – 531C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri537 – 559C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri565 – 587C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri593 – 615C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri621 – 643C2H2-type 15PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00690000102079
HOVERGENiHBG018163
InParanoidiQ0VGE8
KOiK09228
OMAiMREKPCQ
OrthoDBiEOG091G02KC
PhylomeDBiQ0VGE8
TreeFamiTF341892

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 15 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 8 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 15 hits
PS50157 ZINC_FINGER_C2H2_2, 15 hits

Sequencei

Sequence statusi: Complete.

Q0VGE8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLREEATKKS KEKEPGMALP QGRLTFRDVA IEFSLEEWKC LNPAQRALYR
60 70 80 90 100
AVMLENYRNL EFVDSSLKSM MEFSSTRHSI TGEVIHTGTL QRHKSHHIGD
110 120 130 140 150
FCFPEMKKDI HHFEFQWQEV ERNGHEAPMT KIKKLTGSTD RSDHRHAGNK
160 170 180 190 200
PIKDQLGLSF HSHLPELHMF QTKGKISNQL DKSIGASSAS ESQRISCRLK
210 220 230 240 250
THISNKYGKN FLHSSFTQIQ EICMREKPCQ SNECGKAFNY SSLLRRHHIT
260 270 280 290 300
HSREREYKCD VCGKIFNQKQ YIVYHHRCHT GEKTYKCNEC GKTFTQMSSL
310 320 330 340 350
VCHRRLHTGE KPYKCNECGK TFSEKSSLRC HRRLHTGEKP YKCNECGKTF
360 370 380 390 400
GRNSALVIHK AIHTGEKPYK CNECGKTFSQ KSSLQCHHIL HTGEKPYKCE
410 420 430 440 450
ECDNVYIRRS HLERHRKIHT GEGSYKCKVC DKVFRSDSYL AEHQRVHTGE
460 470 480 490 500
KPYKCNKCGR SFSRKSSLQY HHTLHTGEKP YTCNECGKVF SRRENLARHH
510 520 530 540 550
RLHAGEKPYK CEECDKVFSR RSHLERHRRI HTGEKPYKCK VCDKAFRSDS
560 570 580 590 600
CLANHTRVHT GEKPYKCNKC AKVFNQKGIL AQHQRVHTGE KPYKCNECGK
610 620 630 640 650
VFNQKASLAK HQRVHTAEKP YKCNECGKAF TGQSTLIHHQ AIHGCRETLQ

M
Length:651
Mass (Da):75,725
Last modified:March 2, 2010 - v2
Checksum:i833956CE190312A3
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti184I → IS in AAI05741 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03316580I → N1 PublicationCorresponds to variant dbSNP:rs12459008Ensembl.1
Natural variantiVAR_033166162S → L1 PublicationCorresponds to variant dbSNP:rs11084210Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK291990 mRNA Translation: BAF84679.1
AC010487 Genomic DNA No translation available.
AC010328 Genomic DNA No translation available.
CH471135 Genomic DNA Translation: EAW72106.1
BC105739 mRNA Translation: AAI05740.1
BC105740 mRNA Translation: AAI05741.1
BC105930 mRNA Translation: AAI05931.1
AL713804 mRNA Translation: CAH56373.1
CCDSiCCDS33096.1
RefSeqiNP_001026835.1, NM_001031665.2
NP_001189385.1, NM_001202456.1
NP_001189386.1, NM_001202457.1
UniGeneiHs.655592

Genome annotation databases

EnsembliENST00000357666; ENSP00000350295; ENSG00000180257
ENST00000444460; ENSP00000403266; ENSG00000180257
GeneIDi125893
KEGGihsa:125893
UCSCiuc002qal.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiZN816_HUMAN
AccessioniPrimary (citable) accession number: Q0VGE8
Secondary accession number(s): A8K7H5, Q3KR39, Q659B3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: March 2, 2010
Last modified: May 23, 2018
This is version 106 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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