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Protein

Zinc finger protein 816

Gene

ZNF816

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri227 – 25125C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri257 – 27923C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri285 – 30723C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri313 – 33523C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri341 – 36323C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri369 – 39123C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri397 – 41923C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri425 – 44723C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri453 – 47523C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri481 – 50323C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri509 – 53123C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri537 – 55923C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri565 – 58723C2H2-type 13PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri593 – 61523C2H2-type 14PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri621 – 64323C2H2-type 15PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 816
Gene namesi
Name:ZNF816
Synonyms:ZNF816A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:26995. ZNF816.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA165394953.

Polymorphism and mutation databases

BioMutaiZNF816.
DMDMi290457609.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 651651Zinc finger protein 816PRO_0000294362Add
BLAST

Proteomic databases

MaxQBiQ0VGE8.
PaxDbiQ0VGE8.
PRIDEiQ0VGE8.

PTM databases

iPTMnetiQ0VGE8.
PhosphoSiteiQ0VGE8.

Expressioni

Gene expression databases

BgeeiQ0VGE8.
CleanExiHS_ZNF816A.
ExpressionAtlasiQ0VGE8. baseline and differential.
GenevisibleiQ0VGE8. HS.

Organism-specific databases

HPAiHPA042466.

Interactioni

Protein-protein interaction databases

BioGridi125933. 13 interactions.
STRINGi9606.ENSP00000350295.

Structurei

3D structure databases

ProteinModelPortaliQ0VGE8.
SMRiQ0VGE8. Positions 238-649.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini24 – 9875KRABPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 15 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri227 – 25125C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri257 – 27923C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri285 – 30723C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri313 – 33523C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri341 – 36323C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri369 – 39123C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri397 – 41923C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri425 – 44723C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri453 – 47523C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri481 – 50323C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri509 – 53123C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri537 – 55923C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri565 – 58723C2H2-type 13PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri593 – 61523C2H2-type 14PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri621 – 64323C2H2-type 15PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00690000102079.
HOVERGENiHBG018163.
InParanoidiQ0VGE8.
KOiK09228.
OMAiMREKPCQ.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ0VGE8.
TreeFamiTF341892.

Family and domain databases

Gene3Di3.30.160.60. 15 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 4 hits.
PF13912. zf-C2H2_6. 3 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 15 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 15 hits.
PS50157. ZINC_FINGER_C2H2_2. 15 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q0VGE8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLREEATKKS KEKEPGMALP QGRLTFRDVA IEFSLEEWKC LNPAQRALYR
60 70 80 90 100
AVMLENYRNL EFVDSSLKSM MEFSSTRHSI TGEVIHTGTL QRHKSHHIGD
110 120 130 140 150
FCFPEMKKDI HHFEFQWQEV ERNGHEAPMT KIKKLTGSTD RSDHRHAGNK
160 170 180 190 200
PIKDQLGLSF HSHLPELHMF QTKGKISNQL DKSIGASSAS ESQRISCRLK
210 220 230 240 250
THISNKYGKN FLHSSFTQIQ EICMREKPCQ SNECGKAFNY SSLLRRHHIT
260 270 280 290 300
HSREREYKCD VCGKIFNQKQ YIVYHHRCHT GEKTYKCNEC GKTFTQMSSL
310 320 330 340 350
VCHRRLHTGE KPYKCNECGK TFSEKSSLRC HRRLHTGEKP YKCNECGKTF
360 370 380 390 400
GRNSALVIHK AIHTGEKPYK CNECGKTFSQ KSSLQCHHIL HTGEKPYKCE
410 420 430 440 450
ECDNVYIRRS HLERHRKIHT GEGSYKCKVC DKVFRSDSYL AEHQRVHTGE
460 470 480 490 500
KPYKCNKCGR SFSRKSSLQY HHTLHTGEKP YTCNECGKVF SRRENLARHH
510 520 530 540 550
RLHAGEKPYK CEECDKVFSR RSHLERHRRI HTGEKPYKCK VCDKAFRSDS
560 570 580 590 600
CLANHTRVHT GEKPYKCNKC AKVFNQKGIL AQHQRVHTGE KPYKCNECGK
610 620 630 640 650
VFNQKASLAK HQRVHTAEKP YKCNECGKAF TGQSTLIHHQ AIHGCRETLQ

M
Length:651
Mass (Da):75,725
Last modified:March 2, 2010 - v2
Checksum:i833956CE190312A3
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti184 – 1841I → IS in AAI05741 (PubMed:15489334).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti80 – 801I → N.1 Publication
Corresponds to variant rs12459008 [ dbSNP | Ensembl ].
VAR_033165
Natural varianti162 – 1621S → L.1 Publication
Corresponds to variant rs11084210 [ dbSNP | Ensembl ].
VAR_033166

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK291990 mRNA. Translation: BAF84679.1.
AC010487 Genomic DNA. No translation available.
AC010328 Genomic DNA. No translation available.
CH471135 Genomic DNA. Translation: EAW72106.1.
BC105739 mRNA. Translation: AAI05740.1.
BC105740 mRNA. Translation: AAI05741.1.
BC105930 mRNA. Translation: AAI05931.1.
AL713804 mRNA. Translation: CAH56373.1.
CCDSiCCDS33096.1.
RefSeqiNP_001026835.1. NM_001031665.2.
NP_001189385.1. NM_001202456.1.
NP_001189386.1. NM_001202457.1.
UniGeneiHs.655592.

Genome annotation databases

EnsembliENST00000357666; ENSP00000350295; ENSG00000180257.
ENST00000444460; ENSP00000403266; ENSG00000180257.
GeneIDi125893.
KEGGihsa:125893.
UCSCiuc002qal.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK291990 mRNA. Translation: BAF84679.1.
AC010487 Genomic DNA. No translation available.
AC010328 Genomic DNA. No translation available.
CH471135 Genomic DNA. Translation: EAW72106.1.
BC105739 mRNA. Translation: AAI05740.1.
BC105740 mRNA. Translation: AAI05741.1.
BC105930 mRNA. Translation: AAI05931.1.
AL713804 mRNA. Translation: CAH56373.1.
CCDSiCCDS33096.1.
RefSeqiNP_001026835.1. NM_001031665.2.
NP_001189385.1. NM_001202456.1.
NP_001189386.1. NM_001202457.1.
UniGeneiHs.655592.

3D structure databases

ProteinModelPortaliQ0VGE8.
SMRiQ0VGE8. Positions 238-649.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125933. 13 interactions.
STRINGi9606.ENSP00000350295.

PTM databases

iPTMnetiQ0VGE8.
PhosphoSiteiQ0VGE8.

Polymorphism and mutation databases

BioMutaiZNF816.
DMDMi290457609.

Proteomic databases

MaxQBiQ0VGE8.
PaxDbiQ0VGE8.
PRIDEiQ0VGE8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000357666; ENSP00000350295; ENSG00000180257.
ENST00000444460; ENSP00000403266; ENSG00000180257.
GeneIDi125893.
KEGGihsa:125893.
UCSCiuc002qal.3. human.

Organism-specific databases

CTDi125893.
GeneCardsiZNF816.
HGNCiHGNC:26995. ZNF816.
HPAiHPA042466.
neXtProtiNX_Q0VGE8.
PharmGKBiPA165394953.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00690000102079.
HOVERGENiHBG018163.
InParanoidiQ0VGE8.
KOiK09228.
OMAiMREKPCQ.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ0VGE8.
TreeFamiTF341892.

Miscellaneous databases

GenomeRNAii125893.
NextBioi81560.
PROiQ0VGE8.

Gene expression databases

BgeeiQ0VGE8.
CleanExiHS_ZNF816A.
ExpressionAtlasiQ0VGE8. baseline and differential.
GenevisibleiQ0VGE8. HS.

Family and domain databases

Gene3Di3.30.160.60. 15 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 4 hits.
PF13912. zf-C2H2_6. 3 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 15 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 15 hits.
PS50157. ZINC_FINGER_C2H2_2. 15 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Small intestine.
  2. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS ASN-80 AND LEU-162.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 380-651.
    Tissue: Testis.

Entry informationi

Entry nameiZN816_HUMAN
AccessioniPrimary (citable) accession number: Q0VGE8
Secondary accession number(s): A8K7H5, Q3KR39, Q659B3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: March 2, 2010
Last modified: March 16, 2016
This is version 90 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.