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Protein
Submitted name:

Parathyroid hormone 1 receptor

Gene

PTH1R

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptorSAAS annotation, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Submitted name:
Parathyroid hormone 1 receptorImported
Gene namesi
Name:PTH1RImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei189 – 21224HelicalSequence analysisAdd
BLAST
Transmembranei224 – 24522HelicalSequence analysisAdd
BLAST
Transmembranei320 – 34122HelicalSequence analysisAdd
BLAST
Transmembranei361 – 38525HelicalSequence analysisAdd
BLAST
Transmembranei406 – 42621HelicalSequence analysisAdd
BLAST
Transmembranei446 – 46621HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2828Sequence analysisAdd
BLAST
Chaini29 – 593565Sequence analysisPRO_5004178874Add
BLAST

Proteomic databases

PaxDbiQ0VGD7.

Expressioni

Gene expression databases

GenevisibleiQ0VGD7. HS.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000321999.

Structurei

3D structure databases

ProteinModelPortaliQ0VGD7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini47 – 174128G_PROTEIN_RECEP_F2_3InterPro annotationAdd
BLAST
Domaini187 – 463277G_PROTEIN_RECEP_F2_4InterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the G-protein coupled receptor 2 family.SAAS annotation

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG4564. Eukaryota.
ENOG410XRS2. LUCA.
HOVERGENiHBG008318.

Family and domain databases

InterProiIPR017981. GPCR_2-like.
IPR001879. GPCR_2_extracellular_dom.
IPR002170. GPCR_2_parathyroid_rcpt.
IPR000832. GPCR_2_secretin-like.
IPR017983. GPCR_2_secretin-like_CS.
[Graphical view]
PANTHERiPTHR12011:SF24. PTHR12011:SF24. 2 hits.
PfamiPF00002. 7tm_2. 1 hit.
PF02793. HRM. 1 hit.
[Graphical view]
PRINTSiPR00249. GPCRSECRETIN.
PR00393. PTRHORMONER.
SMARTiSM00008. HormR. 1 hit.
[Graphical view]
PROSITEiPS00649. G_PROTEIN_RECEP_F2_1. 1 hit.
PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q0VGD7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGTARIAPGL ALLLCCPVLS SAYALVDADD VMTKEEQIFL LHRAQAQCGK
60 70 80 90 100
RLKEVLQRPA SIMESDKGWT SASTSGKPRK DKASGKLYPE SEEDKEAPTG
110 120 130 140 150
SRYRGRPCLP EWDHILCWPL GAPGEVVAVP CPDYIYDFNH KGHAYRRCDR
160 170 180 190 200
NGSWELVPGH NRTWANYSEC VKFLTNETRE REVFDRLGMI YTVGYSVSLA
210 220 230 240 250
SLTVAVLILA YFRRLHCTRN YIHMHLFLSF MLRAVSIFVK DAVLYSGATL
260 270 280 290 300
DEAERLTEEE LRAIAQAPPP PATAAAGYAG CRVAVTFFLY FLATNYYWIL
310 320 330 340 350
VEGLYLHSLI FMAFFSEKKY LWGFTVFGWG LPAVFVAVWV SVRATLANTG
360 370 380 390 400
CWDLSSGNKK WIIQVPILAS IVLNFILFIN IVRVLATKLR ETNAGRCDTR
410 420 430 440 450
QQYRKLLKST LVLMPLFGVH YIVFMATPYT EVSGTLWQVQ MHYEMLFNSF
460 470 480 490 500
QGFFVAIIYC FCNGEVQAEI KKSWSRWTLA LDFKRKARSG SSSYSYGPMV
510 520 530 540 550
SHTSVTNVGP RVGLGLPLSP RLLPTATTNG HPQLPGHAKP GTPALETLET
560 570 580 590
TPPAMAAPKD DGFLNGSCSG LDEEASGPER PPALLQEEWE TVM
Length:593
Mass (Da):66,289
Last modified:September 5, 2006 - v1
Checksum:iDA81DF2F6B0C7F2B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC110388 mRNA. Translation: AAI10389.1.
RefSeqiNP_001171673.1. NM_001184744.1.
UniGeneiHs.1019.

Genome annotation databases

GeneIDi5745.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC110388 mRNA. Translation: AAI10389.1.
RefSeqiNP_001171673.1. NM_001184744.1.
UniGeneiHs.1019.

3D structure databases

ProteinModelPortaliQ0VGD7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000321999.

Protein family/group databases

GPCRDBiSearch...

Proteomic databases

PaxDbiQ0VGD7.

Protocols and materials databases

DNASUi5745.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi5745.

Organism-specific databases

CTDi5745.

Phylogenomic databases

eggNOGiKOG4564. Eukaryota.
ENOG410XRS2. LUCA.
HOVERGENiHBG008318.

Miscellaneous databases

GenomeRNAii5745.

Gene expression databases

GenevisibleiQ0VGD7. HS.

Family and domain databases

InterProiIPR017981. GPCR_2-like.
IPR001879. GPCR_2_extracellular_dom.
IPR002170. GPCR_2_parathyroid_rcpt.
IPR000832. GPCR_2_secretin-like.
IPR017983. GPCR_2_secretin-like_CS.
[Graphical view]
PANTHERiPTHR12011:SF24. PTHR12011:SF24. 2 hits.
PfamiPF00002. 7tm_2. 1 hit.
PF02793. HRM. 1 hit.
[Graphical view]
PRINTSiPR00249. GPCRSECRETIN.
PR00393. PTRHORMONER.
SMARTiSM00008. HormR. 1 hit.
[Graphical view]
PROSITEiPS00649. G_PROTEIN_RECEP_F2_1. 1 hit.
PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ0VGD7_HUMAN
AccessioniPrimary (citable) accession number: Q0VGD7
Entry historyi
Integrated into UniProtKB/TrEMBL: September 5, 2006
Last sequence update: September 5, 2006
Last modified: June 8, 2016
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.