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Protein
Submitted name:

Parathyroid hormone 1 receptor

Gene

PTH1R

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptorSAAS annotation, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Submitted name:
Parathyroid hormone 1 receptorImported
Gene namesi
Name:PTH1RImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei189 – 212HelicalSequence analysisAdd BLAST24
Transmembranei224 – 245HelicalSequence analysisAdd BLAST22
Transmembranei320 – 341HelicalSequence analysisAdd BLAST22
Transmembranei361 – 385HelicalSequence analysisAdd BLAST25
Transmembranei406 – 426HelicalSequence analysisAdd BLAST21
Transmembranei446 – 466HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 28Sequence analysisAdd BLAST28
ChainiPRO_500417887429 – 593Sequence analysisAdd BLAST565

Proteomic databases

PeptideAtlasiQ0VGD7

Expressioni

Gene expression databases

GenevisibleiQ0VGD7 HS

Structurei

3D structure databases

ProteinModelPortaliQ0VGD7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini47 – 174G_PROTEIN_RECEP_F2_3InterPro annotationAdd BLAST128
Domaini187 – 463G_PROTEIN_RECEP_F2_4InterPro annotationAdd BLAST277

Sequence similaritiesi

Belongs to the G-protein coupled receptor 2 family.SAAS annotation

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG4564 Eukaryota
ENOG410XRS2 LUCA
HOVERGENiHBG008318

Family and domain databases

Gene3Di4.10.1240.10, 1 hit
InterProiView protein in InterPro
IPR017981 GPCR_2-like
IPR036445 GPCR_2_extracell_dom_sf
IPR001879 GPCR_2_extracellular_dom
IPR002170 GPCR_2_parathyroid_rcpt
IPR000832 GPCR_2_secretin-like
IPR017983 GPCR_2_secretin-like_CS
PANTHERiPTHR12011:SF24 PTHR12011:SF24, 1 hit
PfamiView protein in Pfam
PF00002 7tm_2, 1 hit
PF02793 HRM, 1 hit
PRINTSiPR00249 GPCRSECRETIN
PR00393 PTRHORMONER
SMARTiView protein in SMART
SM00008 HormR, 1 hit
SUPFAMiSSF111418 SSF111418, 1 hit
PROSITEiView protein in PROSITE
PS00649 G_PROTEIN_RECEP_F2_1, 1 hit
PS00650 G_PROTEIN_RECEP_F2_2, 1 hit
PS50227 G_PROTEIN_RECEP_F2_3, 1 hit
PS50261 G_PROTEIN_RECEP_F2_4, 1 hit

Sequencei

Sequence statusi: Complete.

Q0VGD7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGTARIAPGL ALLLCCPVLS SAYALVDADD VMTKEEQIFL LHRAQAQCGK
60 70 80 90 100
RLKEVLQRPA SIMESDKGWT SASTSGKPRK DKASGKLYPE SEEDKEAPTG
110 120 130 140 150
SRYRGRPCLP EWDHILCWPL GAPGEVVAVP CPDYIYDFNH KGHAYRRCDR
160 170 180 190 200
NGSWELVPGH NRTWANYSEC VKFLTNETRE REVFDRLGMI YTVGYSVSLA
210 220 230 240 250
SLTVAVLILA YFRRLHCTRN YIHMHLFLSF MLRAVSIFVK DAVLYSGATL
260 270 280 290 300
DEAERLTEEE LRAIAQAPPP PATAAAGYAG CRVAVTFFLY FLATNYYWIL
310 320 330 340 350
VEGLYLHSLI FMAFFSEKKY LWGFTVFGWG LPAVFVAVWV SVRATLANTG
360 370 380 390 400
CWDLSSGNKK WIIQVPILAS IVLNFILFIN IVRVLATKLR ETNAGRCDTR
410 420 430 440 450
QQYRKLLKST LVLMPLFGVH YIVFMATPYT EVSGTLWQVQ MHYEMLFNSF
460 470 480 490 500
QGFFVAIIYC FCNGEVQAEI KKSWSRWTLA LDFKRKARSG SSSYSYGPMV
510 520 530 540 550
SHTSVTNVGP RVGLGLPLSP RLLPTATTNG HPQLPGHAKP GTPALETLET
560 570 580 590
TPPAMAAPKD DGFLNGSCSG LDEEASGPER PPALLQEEWE TVM
Length:593
Mass (Da):66,289
Last modified:September 5, 2006 - v1
Checksum:iDA81DF2F6B0C7F2B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC110388 mRNA Translation: AAI10389.1
RefSeqiNP_001171673.1, NM_001184744.1
UniGeneiHs.1019

Genome annotation databases

GeneIDi5745

Similar proteinsi

Entry informationi

Entry nameiQ0VGD7_HUMAN
AccessioniPrimary (citable) accession number: Q0VGD7
Entry historyiIntegrated into UniProtKB/TrEMBL: September 5, 2006
Last sequence update: September 5, 2006
Last modified: April 25, 2018
This is version 80 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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