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Protein

Coiled-coil domain-containing protein 173

Gene

CCDC173

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Caution

It is uncertain whether Met-1 or Met-7 is the initiator.Curated

Names & Taxonomyi

Protein namesi
Recommended name:
Coiled-coil domain-containing protein 173
Gene namesi
Name:CCDC173
Synonyms:C2orf77
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000154479.12
HGNCiHGNC:25064 CCDC173
neXtProtiNX_Q0VFZ6

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000154479
PharmGKBiPA162379577

Polymorphism and mutation databases

BioMutaiCCDC173
DMDMi327478499

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003188461 – 552Coiled-coil domain-containing protein 173Add BLAST552

Proteomic databases

PaxDbiQ0VFZ6
PeptideAtlasiQ0VFZ6
PRIDEiQ0VFZ6

PTM databases

iPTMnetiQ0VFZ6
PhosphoSitePlusiQ0VFZ6

Expressioni

Gene expression databases

BgeeiENSG00000154479
CleanExiHS_C2orf77
ExpressionAtlasiQ0VFZ6 baseline and differential
GenevisibleiQ0VFZ6 HS

Organism-specific databases

HPAiHPA042995
HPA048454

Interactioni

Protein-protein interaction databases

BioGridi126216, 5 interactors
STRINGi9606.ENSP00000391504

Structurei

3D structure databases

ProteinModelPortaliQ0VFZ6
SMRiQ0VFZ6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili53 – 143Sequence analysisAdd BLAST91
Coiled coili186 – 307Sequence analysisAdd BLAST122
Coiled coili348 – 409Sequence analysisAdd BLAST62
Coiled coili460 – 488Sequence analysisAdd BLAST29

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IERG Eukaryota
ENOG410ZE2M LUCA
GeneTreeiENSGT00730000111149
HOGENOMiHOG000006604
HOVERGENiHBG106646
InParanoidiQ0VFZ6
OMAiAKKEMHF
OrthoDBiEOG091G0JME
PhylomeDBiQ0VFZ6
TreeFamiTF328736

Sequencei

Sequence statusi: Complete.

Q0VFZ6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDTSSEMLVR FGRRCGRAKE STEIRNSEED QVLYLPLLPS KVDLQQVTII
60 70 80 90 100
PHDEWKRIQD SLDRLTREAA CLRAERKAKK EMHLRSQEVV KHWTNTYAGM
110 120 130 140 150
KEQKLEAKKK RDEEIEAERQ ILDLEEEIYK QGKRKKAIEN AKQYQFYQTE
160 170 180 190 200
RVKNFHSGLL LSRVMKERDA QIEFRKSKIK SDKKWEEQLK LNIEKAFKEE
210 220 230 240 250
QEKAEKRHRE RVALAKDHLK QIKEHEEEEE RRKKYEEKDA EEIKRQNALY
260 270 280 290 300
EIEMRKKLEK KREEMHESRR RFLEHMQDKH IIKAVEQQQQ EEEDEKMRKF
310 320 330 340 350
IKAKKRLIQM GKEKEAETHR LMEKRRERIH NFLSELLKEK LDNEDMIIAR
360 370 380 390 400
DIAEAEAEWE KREREKDEKN KAELKTIAEY RAIVMKNKEE EERQRKIEAK
410 420 430 440 450
EQLLAVMKAD QIFWEHEKEK KCKADKEHQE VQDAHIQQMA KNKFNAKQAK
460 470 480 490 500
QAELDYCRLT EALVAEKEKE FQDYAREVIE LESETTNKYI YPLVKAVQEG
510 520 530 540 550
PGGGRGPVFV DRGGLRPSYQ ANDVTGVQLP FYNSQGPKYN FQKSKRRLGF

TW
Length:552
Mass (Da):66,403
Last modified:April 5, 2011 - v2
Checksum:iA727A02E40660938
GO

Sequence cautioni

The sequence AAI17446 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC016772 Genomic DNA No translation available.
BC015980 mRNA Translation: AAH15980.1
BC117445 mRNA Translation: AAI17446.1 Different initiation.
CCDSiCCDS46445.1
RefSeqiNP_001078916.1, NM_001085447.1
UniGeneiHs.370111

Genome annotation databases

EnsembliENST00000447353; ENSP00000391504; ENSG00000154479
GeneIDi129881
KEGGihsa:129881
UCSCiuc002ufe.3 human

Similar proteinsi

Entry informationi

Entry nameiCC173_HUMAN
AccessioniPrimary (citable) accession number: Q0VFZ6
Secondary accession number(s): Q6PJF6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: April 5, 2011
Last modified: February 28, 2018
This is version 81 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
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