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Protein

Coiled-coil domain-containing protein 173

Gene

CCDC173

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Coiled-coil domain-containing protein 173
Gene namesi
Name:CCDC173
Synonyms:C2orf77
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:25064. CCDC173.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162379577.

Polymorphism and mutation databases

BioMutaiCCDC173.
DMDMi327478499.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 552552Coiled-coil domain-containing protein 173PRO_0000318846Add
BLAST

Proteomic databases

PaxDbiQ0VFZ6.
PeptideAtlasiQ0VFZ6.
PRIDEiQ0VFZ6.

PTM databases

iPTMnetiQ0VFZ6.
PhosphoSiteiQ0VFZ6.

Expressioni

Gene expression databases

BgeeiENSG00000154479.
CleanExiHS_C2orf77.
ExpressionAtlasiQ0VFZ6. baseline and differential.
GenevisibleiQ0VFZ6. HS.

Organism-specific databases

HPAiHPA042995.
HPA048454.

Interactioni

Protein-protein interaction databases

BioGridi126216. 4 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ0VFZ6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili53 – 14391Sequence analysisAdd
BLAST
Coiled coili186 – 307122Sequence analysisAdd
BLAST
Coiled coili348 – 40962Sequence analysisAdd
BLAST
Coiled coili460 – 48829Sequence analysisAdd
BLAST

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IERG. Eukaryota.
ENOG410ZE2M. LUCA.
GeneTreeiENSGT00730000111149.
HOGENOMiHOG000006604.
HOVERGENiHBG106646.
InParanoidiQ0VFZ6.
OMAiAKKEMHF.
OrthoDBiEOG091G0JME.
PhylomeDBiQ0VFZ6.
TreeFamiTF328736.

Sequencei

Sequence statusi: Complete.

Q0VFZ6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDTSSEMLVR FGRRCGRAKE STEIRNSEED QVLYLPLLPS KVDLQQVTII
60 70 80 90 100
PHDEWKRIQD SLDRLTREAA CLRAERKAKK EMHLRSQEVV KHWTNTYAGM
110 120 130 140 150
KEQKLEAKKK RDEEIEAERQ ILDLEEEIYK QGKRKKAIEN AKQYQFYQTE
160 170 180 190 200
RVKNFHSGLL LSRVMKERDA QIEFRKSKIK SDKKWEEQLK LNIEKAFKEE
210 220 230 240 250
QEKAEKRHRE RVALAKDHLK QIKEHEEEEE RRKKYEEKDA EEIKRQNALY
260 270 280 290 300
EIEMRKKLEK KREEMHESRR RFLEHMQDKH IIKAVEQQQQ EEEDEKMRKF
310 320 330 340 350
IKAKKRLIQM GKEKEAETHR LMEKRRERIH NFLSELLKEK LDNEDMIIAR
360 370 380 390 400
DIAEAEAEWE KREREKDEKN KAELKTIAEY RAIVMKNKEE EERQRKIEAK
410 420 430 440 450
EQLLAVMKAD QIFWEHEKEK KCKADKEHQE VQDAHIQQMA KNKFNAKQAK
460 470 480 490 500
QAELDYCRLT EALVAEKEKE FQDYAREVIE LESETTNKYI YPLVKAVQEG
510 520 530 540 550
PGGGRGPVFV DRGGLRPSYQ ANDVTGVQLP FYNSQGPKYN FQKSKRRLGF

TW
Length:552
Mass (Da):66,403
Last modified:April 5, 2011 - v2
Checksum:iA727A02E40660938
GO

Sequence cautioni

The sequence AAI17446 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC016772 Genomic DNA. No translation available.
BC015980 mRNA. Translation: AAH15980.1.
BC117445 mRNA. Translation: AAI17446.1. Different initiation.
CCDSiCCDS46445.1.
RefSeqiNP_001078916.1. NM_001085447.1.
UniGeneiHs.370111.

Genome annotation databases

EnsembliENST00000447353; ENSP00000391504; ENSG00000154479.
GeneIDi129881.
KEGGihsa:129881.
UCSCiuc002ufe.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC016772 Genomic DNA. No translation available.
BC015980 mRNA. Translation: AAH15980.1.
BC117445 mRNA. Translation: AAI17446.1. Different initiation.
CCDSiCCDS46445.1.
RefSeqiNP_001078916.1. NM_001085447.1.
UniGeneiHs.370111.

3D structure databases

ProteinModelPortaliQ0VFZ6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126216. 4 interactions.

PTM databases

iPTMnetiQ0VFZ6.
PhosphoSiteiQ0VFZ6.

Polymorphism and mutation databases

BioMutaiCCDC173.
DMDMi327478499.

Proteomic databases

PaxDbiQ0VFZ6.
PeptideAtlasiQ0VFZ6.
PRIDEiQ0VFZ6.

Protocols and materials databases

DNASUi129881.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000447353; ENSP00000391504; ENSG00000154479.
GeneIDi129881.
KEGGihsa:129881.
UCSCiuc002ufe.3. human.

Organism-specific databases

CTDi129881.
GeneCardsiCCDC173.
HGNCiHGNC:25064. CCDC173.
HPAiHPA042995.
HPA048454.
neXtProtiNX_Q0VFZ6.
PharmGKBiPA162379577.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IERG. Eukaryota.
ENOG410ZE2M. LUCA.
GeneTreeiENSGT00730000111149.
HOGENOMiHOG000006604.
HOVERGENiHBG106646.
InParanoidiQ0VFZ6.
OMAiAKKEMHF.
OrthoDBiEOG091G0JME.
PhylomeDBiQ0VFZ6.
TreeFamiTF328736.

Miscellaneous databases

GenomeRNAii129881.
PROiQ0VFZ6.

Gene expression databases

BgeeiENSG00000154479.
CleanExiHS_C2orf77.
ExpressionAtlasiQ0VFZ6. baseline and differential.
GenevisibleiQ0VFZ6. HS.

Family and domain databases

ProtoNetiSearch...

Entry informationi

Entry nameiCC173_HUMAN
AccessioniPrimary (citable) accession number: Q0VFZ6
Secondary accession number(s): Q6PJF6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: April 5, 2011
Last modified: September 7, 2016
This is version 72 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-7 is the initiator.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.