ID   GMPPA_XENTR             Reviewed;         421 AA.
AC   Q0VFM6;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-SEP-2006, sequence version 1.
DT   16-JUN-2009, entry version 26.
DE   RecName: Full=Mannose-1-phosphate guanyltransferase alpha;
DE            EC=2.7.7.13;
DE   AltName: Full=GTP-mannose-1-phosphate guanylyltransferase alpha;
DE   AltName: Full=GDP-mannose pyrophosphorylase A;
GN   Name=gmppa;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Amphibia; Batrachia; Anura; Mesobatrachia; Pipoidea; Pipidae;
OC   Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY: GTP + alpha-D-mannose 1-phosphate =
CC       diphosphate + GDP-mannose.
CC   -!- PATHWAY: Protein modification; protein glycosylation.
CC   -!- SIMILARITY: Belongs to the transferase hexapeptide repeat family.
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DR   EMBL; BC118773; AAI18774.1; -; mRNA.
DR   RefSeq; NP_001072208.1; -.
DR   UniGene; Str.66276; -.
DR   GeneID; 779654; -.
DR   KEGG; xtr:779654; -.
DR   Xenbase; XB-FEAT-984238; gmppa.
DR   HOVERGEN; Q0VFM6; -.
DR   BRENDA; 2.7.7.13; 279072.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004475; F:mannose-1-phosphate guanylyltransferase act...; IEA:EC.
DR   GO; GO:0009058; P:biosynthetic process; IEA:InterPro.
DR   InterPro; IPR001451; Hexapep_transf.
DR   InterPro; IPR018357; Hexapep_transf_CS.
DR   InterPro; IPR005835; NTP_transferase.
DR   Pfam; PF00132; Hexapep; 4.
DR   Pfam; PF00483; NTP_transferase; 1.
DR   PROSITE; PS00101; HEXAPEP_TRANSFERASES; 1.
PE   2: Evidence at transcript level;
KW   GTP-binding; Nucleotide-binding; Nucleotidyltransferase; Transferase.
FT   CHAIN         1    421       Mannose-1-phosphate guanyltransferase
FT                                alpha.
FT                                /FTId=PRO_0000327880.
SQ   SEQUENCE   421 AA;  46232 MW;  6ADD7947E4F48F7B CRC64;
     MLKAVILIGG PQKGTRFRPL SFEVPKPLFP VAGVPMVQHH IEACSKVPNL KEILLIGFYQ
     PNEALSSFLL KAQQEFKVAI RYLQEYSALG TGGGIYHFRD QILSGGPQAF FVMNADVCSA
     FPLVPMLDFH KQHGGSQSYV ILGTTANRSQ SLNYGCIVAN GETQEVLHYV EKPGTFVSDI
     INCGIYLFSP SIFQHIAEVF QRNQQELQLE ENSSWQRTEV IRLEQDVFTT LAGRGKLYVY
     KTEGCWSQIK SAGSAIYASR LYLSQYGSTH PERLASTKEG GPTIRGNVYI HPTANVDPSA
     VLGPNVSIGM GVTVGAGVRI RESIVLHGAV LQDHSCVLNT IVGWDSTVGR WARVEGTPSD
     PNPNDPYSKI DSETLFREGK LTPSITILGC NVSIPAEVVI LNSIVLPHKE LSRSFKNQII
     L
//