Q0VFM6 (GMPPA_XENTR) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Mannose-1-phosphate guanyltransferase alpha
EC=2.7.7.13

Alternative name(s):
GDP-mannose pyrophosphorylase A
GTP-mannose-1-phosphate guanylyltransferase alpha

Gene names

Name:

gmppa

Organism

Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)

Taxonomic identifier

8364 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Mesobatrachia › Pipoidea › Pipidae › Xenopodinae › Xenopus › Silurana

Protein attributes

Sequence length	421 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Catalytic activity	GTP + alpha-D-mannose 1-phosphate = diphosphate + GDP-mannose.
Pathway	Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose biosynthesis; GDP-alpha-D-mannose from alpha-D-mannose 1-phosphate (GTP route): step 1/1.
Sequence similarities	Belongs to the transferase hexapeptide repeat family.

Ontologies

Keywords
Ligand	GTP-binding Nucleotide-binding
Molecular function	Nucleotidyltransferase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	biosynthetic process Inferred from electronic annotation. Source: InterPro
Molecular function	GTP binding Inferred from electronic annotation. Source: UniProtKB-KW mannose-1-phosphate guanylyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 421	421	Mannose-1-phosphate guanyltransferase alpha		PRO_0000327880

Sequences

	Sequence		Length	Mass (Da)
	Q0VFM6 [UniParc]. Last modified September 5, 2006. Version 1. Checksum: 6ADD7947E4F48F7B	FASTA	421	46,232
	10 20 30 40 50 60 MLKAVILIGG PQKGTRFRPL SFEVPKPLFP VAGVPMVQHH IEACSKVPNL KEILLIGFYQ 70 80 90 100 110 120 PNEALSSFLL KAQQEFKVAI RYLQEYSALG TGGGIYHFRD QILSGGPQAF FVMNADVCSA 130 140 150 160 170 180 FPLVPMLDFH KQHGGSQSYV ILGTTANRSQ SLNYGCIVAN GETQEVLHYV EKPGTFVSDI 190 200 210 220 230 240 INCGIYLFSP SIFQHIAEVF QRNQQELQLE ENSSWQRTEV IRLEQDVFTT LAGRGKLYVY 250 260 270 280 290 300 KTEGCWSQIK SAGSAIYASR LYLSQYGSTH PERLASTKEG GPTIRGNVYI HPTANVDPSA 310 320 330 340 350 360 VLGPNVSIGM GVTVGAGVRI RESIVLHGAV LQDHSCVLNT IVGWDSTVGR WARVEGTPSD 370 380 390 400 410 420 PNPNDPYSKI DSETLFREGK LTPSITILGC NVSIPAEVVI LNSIVLPHKE LSRSFKNQII L

References

[1]	NIH - Xenopus Gene Collection (XGC) project Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Testis.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC118773 mRNA. Translation: AAI18774.1.
RefSeq	NP_001072208.1. NM_001078740.1.
UniGene	Str.66276.
3D structure databases
ProteinModelPortal	Q0VFM6.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSXETT00000041701; ENSXETP00000041701; ENSXETG00000019242.
GeneID	779654.
KEGG	xtr:779654.
Organism-specific databases
CTD	29926.
Xenbase	XB-GENE-984239. gmppa.
Phylogenomic databases
eggNOG	veNOG05238.
GeneTree	ENSGT00530000063581.
HOVERGEN	HBG059531.
Gene expression databases
Bgee	Q0VFM6.
Family and domain databases
InterPro	IPR001451. Hexapep_transf. IPR018357. Hexapep_transf_CS. IPR005835. NTP_transferase. [Graphical view]
KO	K00966.
Pfam	PF00132. Hexapep. 1 hit. PF00483. NTP_transferase. 1 hit. [Graphical view]
PROSITE	PS00101. HEXAPEP_TRANSFERASES. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GMPPA_XENTR

Accession

Primary (citable) accession number: Q0VFM6

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 8, 2008
Last sequence update:	September 5, 2006
Last modified:	December 14, 2011
This is version 46 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program