Q0VF99 (Q0VF99_HUMAN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Oxysterol-binding protein RuleBase RU003845

Gene names

Name:	OSBP2 EMBL AAI18915.1 Ensembl ENSP00000392080
ORF Names:	RP3-430N8.7-005 EMBL CAQ07397.1

Organism

Homo sapiens (Human) EMBL AAI18915.1

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	915 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities

Belongs to the OSBP family. RuleBase RU003844 Contains 1 PH domain. RuleBase RU003350

Ontologies

Keywords
Biological process	Lipid transport RuleBase RU003845 Transport
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	lipid transport Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q0VF99 [UniParc]. Last modified September 5, 2006. Version 1. Checksum: 383DAC37FA97D07D	FASTA	915	101,179
	10 20 30 40 50 60 MGKAAAPSRG GGCGGRSRGL SSLFTVVPCL SCHTAAPGMS ASTSGSGPEP KPQPQPVPEP 70 80 90 100 110 120 ERGPLSEQVS EAVSEAVPRS EPVSETTSEP EPGAGQPSEL LQGSRPGSES SSGVGAGPFT 130 140 150 160 170 180 KAASEPLSRA VGSATFLRPE SGSLPALKPL PLLRPGQAKT PLGVPMSGTG TTSSAPLALL 190 200 210 220 230 240 PLDSFEGWLL KWTNYLKGYQ RRWFVLGNGL LSYYRNQGEM AHTCRGTINL STAHIDTEDS 250 260 270 280 290 300 CGILLTSGAR SYHLKASSEV DRQQWITALE LAKAKAVRVM NTHSDDSGDD DEATTPADKS 310 320 330 340 350 360 ELHHTLKNLS LKLDDLSTCN DLIAKHGAAL QRSLTELDGL KIPSESGEKL KVVNERATLF 370 380 390 400 410 420 RITSNAMINA CRDFLELAEI HSRKWQRALQ YEQEQRVHLE ETIEQLAKQH NSLERAFHSA 430 440 450 460 470 480 PGRPANPSKS FIEGSLLTPK GEDSEEDEDT EYFDAMEDST SFITVITEAK EDRKAEGSTG 490 500 510 520 530 540 TSSVDWSSAD NVLDGASLVP KGSSKVKRRV RIPNKPNYSL NLWSIMKNCI GRELSRIPMP 550 560 570 580 590 600 VNFNEPLSML QRLTEDLEYH HLLDKAVHCT SSVEQMCLVA AFSVSSYSTT VHRIAKPFNP 610 620 630 640 650 660 MLGETFELDR LDDMGLRSLC EQVSHHPPSA AHYVFSKHGW SLWQEITISS KFRGKYISIM 670 680 690 700 710 720 PLGAIHLEFQ ASGNHYVWRK STSTVHNIIV GKLWIDQSGD IEIVNHKTND RCQLKFLPYS 730 740 750 760 770 780 YFSKEAARKV TGVVSDSQGK AHYVLSGSWD EQMECSKVMH SSPSSPSSDG KQKTVYQTLS 790 800 810 820 830 840 AKLLWKKYPL PENAENMYYF SELALTLNEH EEGVAPTDSR LRPDQRLMEK GRWDEANTEK 850 860 870 880 890 900 QRLEEKQRLS RRRRLEACGP GSSCSSEEEK EADAYTPLWF EKRLDPLTGE MACVYKGGYW 910 EAKEKQDWHM CPNIF

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The DNA sequence of human chromosome 22." Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M., Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C., Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M. , Buck D., Burgess J., Burrill W.D., Burton J., Carder C., Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G., Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V., Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M., Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A., Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C., Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E., Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F., Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M., Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A., Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D., Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y., Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S., Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E., Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L., Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L., Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N., Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A., Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L., Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P., Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P., Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q., Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J., Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J., Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D., Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T., Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P., Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K., Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R., Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L., McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J., Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E., Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P., Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y., Wright H. Nature 402:489-495(1999) [PubMed: 10591208] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: PCR rescued clones EMBL AAI18915.1.
[3]	Bird C. Submitted (JAN-2009) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
[4]	Steward C. Submitted (JAN-2009) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
[5]	Ensembl Submitted (JUL-2011) to UniProtKB Cited for: IDENTIFICATION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC118914 mRNA. Translation: AAI18915.1. AL079299, AC004542, AL022336 Genomic DNA. Translation: CAQ07397.1. AL022336, AC004542, AL079299 Genomic DNA. Translation: CAQ07893.1.
IPI	IPI00878043.
UniGene	Hs.517546.
3D structure databases
ProteinModelPortal	Q0VF99.
SMR	Q0VF99. Positions 7-43, 182-277.
ModBase	Search...
Protein-protein interaction databases
STRING	Q0VF99.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000446658; ENSP00000392080; ENSG00000184792.
Organism-specific databases
HGNC	HGNC:8504. OSBP2.
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	HBG053374.
Gene expression databases
ArrayExpress	Q0VF99.
Bgee	Q0VF99.
Family and domain databases
InterPro	IPR000648. Oxysterol-bd. IPR018494. Oxysterol-bd_CS. IPR011993. PH_type. IPR001849. Pleckstrin_homology. [Graphical view]
Gene3D	G3DSA:2.30.29.30. PH_type. 1 hit.
PANTHER	PTHR10972. Oxysterol_bd. 1 hit.
Pfam	PF01237. Oxysterol_BP. 1 hit. PF00169. PH. 1 hit. [Graphical view]
SMART	SM00233. PH. 1 hit. [Graphical view]
PROSITE	PS01013. OSBP. 1 hit. PS50003. PH_DOMAIN. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q0VF99_HUMAN

Accession

Primary (citable) accession number: Q0VF99

Entry history

Integrated into UniProtKB/TrEMBL:	September 5, 2006
Last sequence update:	September 5, 2006
Last modified:	November 16, 2011
This is version 43 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.