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Q0VF58

- COJA1_MOUSE

UniProt

Q0VF58 - COJA1_MOUSE

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Protein
Collagen alpha-1(XIX) chain
Gene
Col19a1
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

May act as a cross-bridge between fibrils and other extracellular matrix molecules. Involved in skeletal myogenesis in the developing esophagus. May play a role in organization of the pericellular matrix or the sphinteric smooth muscle.1 Publication

GO - Biological processi

  1. cell adhesion Source: UniProtKB-KW
  2. cell differentiation Source: UniProtKB-KW
  3. extracellular matrix organization Source: MGI
  4. skeletal muscle tissue development Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Cell adhesion, Differentiation, Myogenesis

Enzyme and pathway databases

ReactomeiREACT_198984. Collagen biosynthesis and modifying enzymes.
REACT_199055. Collagen degradation.

Names & Taxonomyi

Protein namesi
Recommended name:
Collagen alpha-1(XIX) chain
Alternative name(s):
Collagen alpha-1(Y) chain
Gene namesi
Name:Col19a1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 1

Organism-specific databases

MGIiMGI:1095415. Col19a1.

Subcellular locationi

GO - Cellular componenti

  1. collagen trimer Source: UniProtKB-KW
  2. proteinaceous extracellular matrix Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

Pathology & Biotechi

Disruption phenotypei

Mice show severe signs of malnourishment and the majority die within the first three weeks of postnatal life. Newborn homozygotes do not show gross anatomical abnormalities, except for smaller size of the internal organs. However, necroscopy of the mice that survive past the weaning stage reveals a dilated esophagus (megaesophagus) with retention of ingesta immediately above the diaphragm level. Mutant mice also exhibit an additional defect, namely impaired smooth-to-skeletal muscle cell transdifferentiation in the abdominal segment of the esophagus. Heterozygotes by comparison are morphologically normal, viable and fertile.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323 Reviewed prediction
Add
BLAST
Chaini24 – 11361113Collagen alpha-1(XIX) chain
PRO_0000284731Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi47 – 471N-linked (GlcNAc...) Reviewed prediction

Post-translational modificationi

Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.

Keywords - PTMi

Disulfide bond, Glycoprotein, Hydroxylation

Proteomic databases

PaxDbiQ0VF58.
PRIDEiQ0VF58.

PTM databases

PhosphoSiteiQ0VF58.

Expressioni

Developmental stagei

Expressed in the myotome of somites from E9.5. In muscular tissues, expression is transient and is confined to a few sites of the developing embryo, such as limbs, tongue, and smooth muscle layers of stomach and esophagus. Also detected in skin at E16.5 and in cerebral cortex and hippocampus of the newborn brain. In adult, expression is only observed in cerebrum, cerebellum, eyes, and testis. In CNS, expression gradually increases following birth. Also expressed in embryonic fibroblasts and to a lesser extent in adult fibroblasts.2 Publications

Gene expression databases

ArrayExpressiQ0VF58.
BgeeiQ0VF58.
CleanExiMM_COL19A1.
GenevestigatoriQ0VF58.

Interactioni

Subunit structurei

Oligomer; disulfide-linked By similarity.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ0VF58.
SMRiQ0VF58. Positions 48-242.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini47 – 231185Laminin G-like
Add
BLAST
Domaini292 – 34655Collagen-like 1
Add
BLAST
Domaini347 – 38842Collagen-like 2
Add
BLAST
Domaini389 – 43042Collagen-like 3
Add
BLAST
Domaini519 – 57759Collagen-like 4
Add
BLAST
Domaini578 – 61841Collagen-like 5
Add
BLAST
Domaini620 – 67354Collagen-like 6
Add
BLAST
Domaini722 – 77756Collagen-like 7
Add
BLAST
Domaini778 – 81033Collagen-like 8
Add
BLAST
Domaini833 – 89159Collagen-like 9
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni289 – 34860Triple-helical region 1 (COL1)
Add
BLAST
Regioni367 – 42660Triple-helical region 2 (COL2)
Add
BLAST
Regioni442 – 682241Triple-helical region 3 (COL3)
Add
BLAST
Regioni694 – 812119Triple-helical region 4 (COL4)
Add
BLAST
Regioni827 – 1006180Triple-helical region 5 (COL5)
Add
BLAST
Regioni1048 – 110558Triple-helical region 6 (COL6)
Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi946 – 9483Cell attachment site Reviewed prediction

Domaini

The numerous interruptions in the triple helix may make this molecule either elastic or flexible By similarity.By similarity

Sequence similaritiesi

Keywords - Domaini

Collagen, Repeat, Signal

Phylogenomic databases

eggNOGiNOG275976.
GeneTreeiENSGT00750000117628.
HOGENOMiHOG000085653.
HOVERGENiHBG060240.
InParanoidiQ0VF58.
OMAiERWFLWQ.
OrthoDBiEOG7353W7.
PhylomeDBiQ0VF58.
TreeFamiTF351778.

Family and domain databases

InterProiIPR008160. Collagen.
IPR008985. ConA-like_lec_gl_sf.
IPR001791. Laminin_G.
[Graphical view]
PfamiPF01391. Collagen. 9 hits.
[Graphical view]
SMARTiSM00210. TSPN. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q0VF58-1 [UniParc]FASTAAdd to Basket

« Hide

MRHTGSWKLW TWVTTFLLPA CTCLTVRDKP ETTCPTLRTE RYQDDRNKSE     50
LSGFDLGESF ALRHAFCEGD KTCFKLGSVL LIRDTVKIFP KGLPEEYAIA 100
VMFRVRRSTK KERWFLWKIL NQQNMAQISV VIDGTKKVVE FMFRGAEGDL 150
LNYVFKNREL RPLFDRQWHK LGIGVQSRVL SLYMDCNLIA SRHTEEKNSV 200
DFQGRTIIAA RASDGKPVDI ELHQLRIYCN ANFLAEESCC NLSPTKCPEQ 250
DDFGSTTSSW GTSNTGKMSS YLPGKQELKD TCQCIPNKEE AGLPGTLRSI 300
GHKGDKGEPG EHGLDGTPGL PGQKGEQGLE GIKGEIGEKG EPGAKGDSGL 350
DGLNGQDGLK GDSGPQGPPG PKGDKGDMGP PGPPALTGSI GIQGPQGPPG 400
KEGQRGRRGK TGPPGNPGPP GPPGPPGLQG LQQPFGGYFN KGTGEHGASG 450
PKGEKGDTGL PGFPGSVGPK GHKGEPGEPL TKGEKGDRGE PGLLGPQGIK 500
GEPGDPGPPG LLGSPGLKGQ QGPAGSMGPR GPPGDVGLPG EHGIPGKQGV 550
KGEKGDPGGR LGPPGLPGLK GDAGPPGISL PGKPGLDGNP GSPGPRGPKG 600
ERGLPGLHGS PGDTGPPGVG IPGRTGSQGP AGEPGIQGPR GLPGLPGTPG 650
MPGNDGAPGK DGKPGLPGPP GDPIALPLLG DIGALLKNFC GNCQANVPGL 700
KSIKGDDGST GEPGKYDPAA RKGDVGPRGP PGFPGREGPK GSKGERGYPG 750
IHGEKGDEGL QGIPGLSGAP GPTGPPGLTG RTGHPGPTGA KGDKGSEGPP 800
GKPGPPGPPG VPLNEGNGMS SLYKIQGGVN VPGYPGPPGP PGPKGDPGPV 850
GEPGAMGLPG LEGFPGVKGD RGPAGPPGIA GISGKPGAPG PPGVPGEQGE 900
RGPIGDTGFP GPEGPSGKPG INGKDGLPGA QGIMGKPGDR GPKGERGDQG 950
IPGDRGPQGE RGKPGLTGMK GAIGPVGPAG SKGSTGPPGH QGPPGNPGIP 1000
GTPADAVSFE EIKHYINQEV LRIFEERMAV FLSQLKLPAA MLSAQAHGRP 1050
GPPGKDGLPG PPGDPGPQGY RGQKGERGEP GIGLPGSPGL PGSSAVGLPG 1100
SPGAPGPQGP PGPSGRCNPE DCLYPAPPPH QQAGGK 1136
Length:1,136
Mass (Da):114,197
Last modified:April 17, 2007 - v2
Checksum:iC480216027D70B43
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti110 – 1101K → Q in BAA23578. 1 Publication
Sequence conflicti315 – 3151D → N in BAA23578. 1 Publication
Sequence conflicti315 – 3151D → N in AAI18971. 1 Publication
Sequence conflicti528 – 5281G → K in BAA23578. 1 Publication
Sequence conflicti597 – 5971G → E in BAA23578. 1 Publication
Sequence conflicti717 – 7171D → E in BAA23578. 1 Publication
Sequence conflicti717 – 7171D → E in AAI18971. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB000636 mRNA. Translation: BAA23578.1.
AC116998 Genomic DNA. No translation available.
AC130201 Genomic DNA. No translation available.
AC161879 Genomic DNA. No translation available.
BC118970 mRNA. Translation: AAI18971.1.
CCDSiCCDS14854.1.
RefSeqiNP_031759.2. NM_007733.2.
XP_006495708.1. XM_006495645.1.
UniGeneiMm.329196.

Genome annotation databases

EnsembliENSMUST00000115244; ENSMUSP00000110899; ENSMUSG00000026141.
GeneIDi12823.
KEGGimmu:12823.
UCSCiuc007amq.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB000636 mRNA. Translation: BAA23578.1 .
AC116998 Genomic DNA. No translation available.
AC130201 Genomic DNA. No translation available.
AC161879 Genomic DNA. No translation available.
BC118970 mRNA. Translation: AAI18971.1 .
CCDSi CCDS14854.1.
RefSeqi NP_031759.2. NM_007733.2.
XP_006495708.1. XM_006495645.1.
UniGenei Mm.329196.

3D structure databases

ProteinModelPortali Q0VF58.
SMRi Q0VF58. Positions 48-242.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q0VF58.

Proteomic databases

PaxDbi Q0VF58.
PRIDEi Q0VF58.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000115244 ; ENSMUSP00000110899 ; ENSMUSG00000026141 .
GeneIDi 12823.
KEGGi mmu:12823.
UCSCi uc007amq.1. mouse.

Organism-specific databases

CTDi 1310.
MGIi MGI:1095415. Col19a1.

Phylogenomic databases

eggNOGi NOG275976.
GeneTreei ENSGT00750000117628.
HOGENOMi HOG000085653.
HOVERGENi HBG060240.
InParanoidi Q0VF58.
OMAi ERWFLWQ.
OrthoDBi EOG7353W7.
PhylomeDBi Q0VF58.
TreeFami TF351778.

Enzyme and pathway databases

Reactomei REACT_198984. Collagen biosynthesis and modifying enzymes.
REACT_199055. Collagen degradation.

Miscellaneous databases

NextBioi 282302.
PROi Q0VF58.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q0VF58.
Bgeei Q0VF58.
CleanExi MM_COL19A1.
Genevestigatori Q0VF58.

Family and domain databases

InterProi IPR008160. Collagen.
IPR008985. ConA-like_lec_gl_sf.
IPR001791. Laminin_G.
[Graphical view ]
Pfami PF01391. Collagen. 9 hits.
[Graphical view ]
SMARTi SM00210. TSPN. 1 hit.
[Graphical view ]
SUPFAMi SSF49899. SSF49899. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Ubiquitous expression of the alpha1(XIX) collagen gene (Col19a1) during mouse embryogenesis becomes restricted to a few tissues in the adult organism."
    Sumiyoshi H., Inoguchi K., Khaleduzzaman M., Ninomiya Y., Yoshioka H.
    J. Biol. Chem. 272:17104-17111(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], DEVELOPMENTAL STAGE.
    Strain: BALB/c.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "Embryonic expression of type XIX collagen is transient and confined to muscle cells."
    Sumiyoshi H., Laub F., Yoshioka H., Ramirez F.
    Dev. Dyn. 220:155-162(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: DEVELOPMENTAL STAGE.
  5. "Esophageal muscle physiology and morphogenesis require assembly of a collagen XIX-rich basement membrane zone."
    Sumiyoshi H., Mor N., Lee S.Y., Doty S., Henderson S., Tanaka S., Yoshioka H., Rattan S., Ramirez F.
    J. Cell Biol. 166:591-600(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, DISRUPTION PHENOTYPE.

Entry informationi

Entry nameiCOJA1_MOUSE
AccessioniPrimary (citable) accession number: Q0VF58
Secondary accession number(s): O35053
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 17, 2007
Last sequence update: April 17, 2007
Last modified: September 3, 2014
This is version 70 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi