Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein
Submitted name:

Gamma-aminobutyric acid (GABA-A) receptor, subunit theta

Gene

Gabrq

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

Keywordsi

Molecular functionIon channelUniRule annotationSAAS annotation, ReceptorImported
Biological processIon transport, Transport

Names & Taxonomyi

Protein namesi
Submitted name:
Gamma-aminobutyric acid (GABA-A) receptor, subunit thetaImported
Gene namesi
Name:GabrqImported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:1888498. Gabrq.

Subcellular locationi

  • Cell junctionsynapse SAAS annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei267 – 286HelicalSequence analysisAdd BLAST20
Transmembranei293 – 310HelicalSequence analysisAdd BLAST18
Transmembranei330 – 353HelicalSequence analysisAdd BLAST24
Transmembranei616 – 635HelicalSequence analysisAdd BLAST20

GO - Cellular componenti

Keywords - Cellular componenti

Cell junction, Cell membraneSAAS annotation, Membrane, SynapseSAAS annotation

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_501013420722 – 638Sequence analysisAdd BLAST617

Keywords - PTMi

Disulfide bondSAAS annotation

Expressioni

Gene expression databases

BgeeiENSMUSG00000031344.
ExpressionAtlasiQ0VEX8. baseline and differential.

Structurei

3D structure databases

SMRiQ0VEX8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini60 – 263Neur_chan_LBDInterPro annotationAdd BLAST204
Domaini271 – 441Neur_chan_membInterPro annotationAdd BLAST171

Sequence similaritiesi

Belongs to the ligand-gated ion channel (TC 1.A.9) family. [View classification]UniRule annotationSAAS annotation

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG3643. Eukaryota.
ENOG410XPWH. LUCA.
HOVERGENiHBG051708.
KOiK05192.
OMAiFFHQTWK.
OrthoDBiEOG091G0805.

Family and domain databases

Gene3Di2.70.170.10. 1 hit.
InterProiView protein in InterPro
IPR006028. GABAA/Glycine_rcpt.
IPR008101. GABAAt_rcpt.
IPR006202. Neur_chan_lig-bd.
IPR006201. Neur_channel.
IPR006029. Neurotrans-gated_channel_TM.
IPR018000. Neurotransmitter_ion_chnl_CS.
PANTHERiPTHR18945. PTHR18945. 1 hit.
PTHR18945:SF606. PTHR18945:SF606. 1 hit.
PfamiView protein in Pfam
PF02931. Neur_chan_LBD. 1 hit.
PF02932. Neur_chan_memb. 1 hit.
PRINTSiPR00253. GABAARECEPTR.
PR01725. GABAARTHETA.
PR00252. NRIONCHANNEL.
SUPFAMiSSF63712. SSF63712. 1 hit.
SSF90112. SSF90112. 3 hits.
TIGRFAMsiTIGR00860. LIC. 1 hit.
PROSITEiView protein in PROSITE
PS00236. NEUROTR_ION_CHANNEL. 1 hit.

Sequencei

Sequence statusi: Complete.

Q0VEX8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGIRGMLRAA ALLLLIRTWL AESNGPSPTP KFHFELSSST PEVILDLFNC
60 70 80 90 100
KNCANEAVVQ KILDRVLSTY DVRLRPNFGG APVPVSVSIY VSSIEQISEI
110 120 130 140 150
NMDYTITMFL HQTWKDTRLA YYETNLNLTL DYRMHEKLWV PDCYFVNSKD
160 170 180 190 200
AFVHDVTVEN RVFQLHPDGT VRYGIRLTTT AACSLDLQKF PMDKQSCKLE
210 220 230 240 250
VESYGYTVED IVLSWEDDNA IHITDGLHIP QYTYLGRTIT SKEVYFYTGS
260 270 280 290 300
YMRLIVKFQV QREVRSYLVQ VYWPTVLTTI LSWISFWMNY DSSAARVTIG
310 320 330 340 350
LTSILVLTTI DSHMRDKLPH ISCIKAIDIY ILVCLFFVFL SLLEYVYINY
360 370 380 390 400
LFFSQVPRRN HRRCRKPRRV VARYRYQEVV VANVQDGLIN VEDRVEDRAG
410 420 430 440 450
PLPDSPMQAH LASQESLGSL VFTSEQAQLA TSESLSLLSS ASSQTQLATG
460 470 480 490 500
ESLSDLPSTS EQTVPECTIH FHGFLTNDSI IPIKIHSRSD ACDDEDSEES
510 520 530 540 550
LSSEESHGHG SSHTGRLKLQ ISQRCVQEAS WDLDKIEILQ DDISITSSWL
560 570 580 590 600
GLDEQCKGDA DSIWSLTDEE LMACDQEKDS SSESEENCSP SPGCSFNEGF
610 620 630
SFQLFKPNRV PKVDRWSRFL FPLSFGLFNV VYWLYHVY
Length:638
Mass (Da):72,799
Last modified:September 5, 2006 - v1
Checksum:i4E2C4FA02E9BF8A3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC119074 mRNA. Translation: AAI19075.1.
BC119076 mRNA. Translation: AAI19077.1.
RefSeqiNP_065234.1. NM_020488.2.
XP_006528236.1. XM_006528173.1.
UniGeneiMm.117125.
Mm.487532.

Genome annotation databases

GeneIDi57249.
KEGGimmu:57249.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiQ0VEX8_MOUSE
AccessioniPrimary (citable) accession number: Q0VEX8
Entry historyiIntegrated into UniProtKB/TrEMBL: September 5, 2006
Last sequence update: September 5, 2006
Last modified: July 5, 2017
This is version 106 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)