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Protein
Submitted name:

5-hydroxytryptamine (Serotonin) receptor 1B

Gene

Htr1b

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptorUniRule annotationSAAS annotation, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Submitted name:
5-hydroxytryptamine (Serotonin) receptor 1BImported
Submitted name:
MCG4326Imported
Gene namesi
Name:Htr1bImported
ORF Names:mCG_4326Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:96274. Htr1b.

Subcellular locationi

  • Cell membrane SAAS annotation; Multi-pass membrane protein SAAS annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei46 – 70HelicalSequence analysisAdd BLAST25
Transmembranei82 – 101HelicalSequence analysisAdd BLAST20
Transmembranei121 – 141HelicalSequence analysisAdd BLAST21
Transmembranei162 – 182HelicalSequence analysisAdd BLAST21
Transmembranei202 – 224HelicalSequence analysisAdd BLAST23
Transmembranei311 – 335HelicalSequence analysisAdd BLAST25
Transmembranei341 – 360HelicalSequence analysisAdd BLAST20

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membraneSAAS annotation, Membrane

PTM / Processingi

Keywords - PTMi

Disulfide bondSAAS annotation

Expressioni

Gene expression databases

BgeeiENSMUSG00000049511.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000050898.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini62 – 365G_PROTEIN_RECEP_F1_2InterPro annotationAdd BLAST304

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.UniRule annotationSAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
HOVERGENiHBG106962.
KOiK04153.
OMAiVNTDHVL.
OrthoDBiEOG091G06VI.

Family and domain databases

InterProiIPR002147. 5HT1B_rcpt.
IPR002231. 5HT_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR24247:SF16. PTHR24247:SF16. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00513. 5HT1BRECEPTR.
PR01101. 5HTRECEPTOR.
PR00237. GPCRRHODOPSN.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q0VES5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEEQGIQCAP PPPAASQTGV PLTNLSHNCS ADGYIYQDSI ALPWKVLLVA
60 70 80 90 100
LLALITLATT LSNAFVIATV YRTRKLHTPA NYLIASLAVT DLLVSILVMP
110 120 130 140 150
ISTMYTVTGR WTLGQVVCDF WLSSDITCCT ASIMHLCVIA LDRYWAITDA
160 170 180 190 200
VEYSAKRTPK RAAIMIVLVW VFSISISLPP FFWRQAKAEE EMLDCFVNTD
210 220 230 240 250
HVLYTVYSTV GAFYLPTLLL IALYGRIYVE ARSRILKQTP NKTGKRLTRA
260 270 280 290 300
QLITDSPGST SSVTSINSRA PDVPSESGSP VYVNQVKVRV SDALLEKKKL
310 320 330 340 350
MAARERKATK TLGIILGAFI VCWLPFFIIS LVMPICKDAC WFHMAIFDFF
360 370 380
NWLGYLNSLI NPIIYTMSNE DFKQAFHKLI RFKCAG
Length:386
Mass (Da):43,079
Last modified:September 5, 2006 - v1
Checksum:i58F70FBEA770C0B3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC119129 mRNA. Translation: AAI19130.1.
BC131951 mRNA. Translation: AAI31952.1.
CH466522 Genomic DNA. Translation: EDL26441.1.
RefSeqiNP_034612.1. NM_010482.1.
UniGeneiMm.445308.

Genome annotation databases

GeneIDi15551.
KEGGimmu:15551.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC119129 mRNA. Translation: AAI19130.1.
BC131951 mRNA. Translation: AAI31952.1.
CH466522 Genomic DNA. Translation: EDL26441.1.
RefSeqiNP_034612.1. NM_010482.1.
UniGeneiMm.445308.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000050898.

Protein family/group databases

GPCRDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi15551.
KEGGimmu:15551.

Organism-specific databases

CTDi3351.
MGIiMGI:96274. Htr1b.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
HOVERGENiHBG106962.
KOiK04153.
OMAiVNTDHVL.
OrthoDBiEOG091G06VI.

Miscellaneous databases

SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000049511.

Family and domain databases

InterProiIPR002147. 5HT1B_rcpt.
IPR002231. 5HT_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR24247:SF16. PTHR24247:SF16. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00513. 5HT1BRECEPTR.
PR01101. 5HTRECEPTOR.
PR00237. GPCRRHODOPSN.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ0VES5_MOUSE
AccessioniPrimary (citable) accession number: Q0VES5
Entry historyi
Integrated into UniProtKB/TrEMBL: September 5, 2006
Last sequence update: September 5, 2006
Last modified: November 30, 2016
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.