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Protein

Centrosomal protein of 76 kDa

Gene

Cep76

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Centrosomal protein involved in regulation of centriole duplication. Required to limit centriole duplication to once per cell cycle by preventing centriole reduplication (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-MMU-2565942. Regulation of PLK1 Activity at G2/M Transition.
R-MMU-380259. Loss of Nlp from mitotic centrosomes.
R-MMU-380270. Recruitment of mitotic centrosome proteins and complexes.
R-MMU-5620912. Anchoring of the basal body to the plasma membrane.
R-MMU-8854518. AURKA Activation by TPX2.

Names & Taxonomyi

Protein namesi
Recommended name:
Centrosomal protein of 76 kDa
Short name:
Cep76
Gene namesi
Name:Cep76
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 18

Organism-specific databases

MGIiMGI:1923401. Cep76.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 659659Centrosomal protein of 76 kDaPRO_0000378949Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei75 – 751PhosphoserineCombined sources
Modified residuei83 – 831PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ0VEJ0.
MaxQBiQ0VEJ0.
PaxDbiQ0VEJ0.
PRIDEiQ0VEJ0.

PTM databases

iPTMnetiQ0VEJ0.
PhosphoSiteiQ0VEJ0.

Expressioni

Gene expression databases

BgeeiQ0VEJ0.
GenevisibleiQ0VEJ0. MM.

Interactioni

Subunit structurei

Interacts with CCP110 and CEP97.By similarity

Protein-protein interaction databases

BioGridi230419. 19 interactions.
IntActiQ0VEJ0. 19 interactions.
STRINGi10090.ENSMUSP00000095149.

Structurei

3D structure databases

ProteinModelPortaliQ0VEJ0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CEP76 family.Curated

Phylogenomic databases

eggNOGiENOG410IFDB. Eukaryota.
ENOG410XWNZ. LUCA.
GeneTreeiENSGT00390000000781.
HOGENOMiHOG000008143.
InParanoidiQ0VEJ0.
KOiK16457.
OMAiSACAVWI.
OrthoDBiEOG7JQBMW.
PhylomeDBiQ0VEJ0.
TreeFamiTF329324.

Family and domain databases

InterProiIPR028926. CEP76-C2.
[Graphical view]
PfamiPF15627. CEP76-C2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q0VEJ0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLPPEKASE LKQLIHQQLS KMDVHGRIRE ILAETIREEL APDQQHLSTE
60 70 80 90 100
DLIKALRRRG IIDDVMKELN FVTDSVDQEL PSSPKQTVGF DKQSTLKKTN
110 120 130 140 150
VDPTRRYLYL QVLGGKAFLE HLQEPEPLPG QICSTFTLCL HYRNQRFRSK
160 170 180 190 200
PVPCACEPDF HDGFLLEVHR ESLGDGTRMA DSTTMLSISD PIHMVLIKTD
210 220 230 240 250
IFGETTLVAS YFLEWRSVLG SENGVTNLTV ELMGVGTESK VSVGILNIKL
260 270 280 290 300
EMYPPLSQTL SQEVVNTQLA LERQKTAEKE RLFLVYAKQW WREYLQIRPS
310 320 330 340 350
HNSRLVKIFA QDENGINRPV CSYVKPLRAG RLLDTPRQAA RFVNVLGYER
360 370 380 390 400
APVIGGGGKQ EQWCTLLAFL CRNKGDCEDH ANLLCSLLLG YGLEAFVCVG
410 420 430 440 450
TKAKGAPHAW VMTCGTDGTI MFWESLTGHR YIHKPTNPDG PPLAEQPKPL
460 470 480 490 500
YPYRTIGCVF NHQMFLGNCQ PSDAVETCIF DLNDESKWKP MSEEAIKSVC
510 520 530 540 550
APGATTSLPP FPPLCASTID ASVTSNEIEM QLRLLVSEHR KDLGLTTVWE
560 570 580 590 600
DQLSYLLSPA LASYEFERTT SISAGNEEFQ DAIRRAVPDG HTFKGFPIHF
610 620 630 640 650
VYRNARRAFA TCLRSPFCEE IICCRGDQVR LAVRVRVFTY PESACAVWIM

FACKYRSVL
Length:659
Mass (Da):74,303
Last modified:September 5, 2006 - v1
Checksum:i658CF10C0C3A74B5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH466528 Genomic DNA. Translation: EDL09636.1.
BC119216 mRNA. Translation: AAI19217.1.
BC119218 mRNA. Translation: AAI19219.1.
CCDSiCCDS37850.1.
RefSeqiNP_001074542.1. NM_001081073.1.
UniGeneiMm.111928.

Genome annotation databases

EnsembliENSMUST00000097542; ENSMUSP00000095149; ENSMUSG00000073542.
GeneIDi225659.
KEGGimmu:225659.
UCSCiuc008fmq.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH466528 Genomic DNA. Translation: EDL09636.1.
BC119216 mRNA. Translation: AAI19217.1.
BC119218 mRNA. Translation: AAI19219.1.
CCDSiCCDS37850.1.
RefSeqiNP_001074542.1. NM_001081073.1.
UniGeneiMm.111928.

3D structure databases

ProteinModelPortaliQ0VEJ0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi230419. 19 interactions.
IntActiQ0VEJ0. 19 interactions.
STRINGi10090.ENSMUSP00000095149.

PTM databases

iPTMnetiQ0VEJ0.
PhosphoSiteiQ0VEJ0.

Proteomic databases

EPDiQ0VEJ0.
MaxQBiQ0VEJ0.
PaxDbiQ0VEJ0.
PRIDEiQ0VEJ0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000097542; ENSMUSP00000095149; ENSMUSG00000073542.
GeneIDi225659.
KEGGimmu:225659.
UCSCiuc008fmq.1. mouse.

Organism-specific databases

CTDi79959.
MGIiMGI:1923401. Cep76.

Phylogenomic databases

eggNOGiENOG410IFDB. Eukaryota.
ENOG410XWNZ. LUCA.
GeneTreeiENSGT00390000000781.
HOGENOMiHOG000008143.
InParanoidiQ0VEJ0.
KOiK16457.
OMAiSACAVWI.
OrthoDBiEOG7JQBMW.
PhylomeDBiQ0VEJ0.
TreeFamiTF329324.

Enzyme and pathway databases

ReactomeiR-MMU-2565942. Regulation of PLK1 Activity at G2/M Transition.
R-MMU-380259. Loss of Nlp from mitotic centrosomes.
R-MMU-380270. Recruitment of mitotic centrosome proteins and complexes.
R-MMU-5620912. Anchoring of the basal body to the plasma membrane.
R-MMU-8854518. AURKA Activation by TPX2.

Miscellaneous databases

PROiQ0VEJ0.
SOURCEiSearch...

Gene expression databases

BgeeiQ0VEJ0.
GenevisibleiQ0VEJ0. MM.

Family and domain databases

InterProiIPR028926. CEP76-C2.
[Graphical view]
PfamiPF15627. CEP76-C2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  3. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-75 AND SER-83, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain and Lung.

Entry informationi

Entry nameiCEP76_MOUSE
AccessioniPrimary (citable) accession number: Q0VEJ0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 7, 2009
Last sequence update: September 5, 2006
Last modified: June 8, 2016
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.