Q0VE82 (CPNE7_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Copine-7

Alternative name(s):
Copine VII

Gene names

Name:

Cpne7

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	557 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	May function in membrane trafficking. Exhibits calcium-dependent phospholipid binding properties By similarity. UniProtKB Q99829
Sequence similarities	Belongs to the copine family. Contains 2 C2 domains. Contains 1 VWFA domain.

Ontologies

Keywords
Domain	Repeat
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	plasma membrane Traceable author statement. Source: Reactome
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 557	557	Copine-7		PRO_0000375983
Regions
	Domain	6 – 112	107	C2 1
	Domain	139 – 244	106	C2 2
	Domain	306 – 505	200	VWFA

Sequences

	Sequence		Length	Mass (Da)
	Q0VE82 [UniParc]. Last modified September 5, 2006. Version 1. Checksum: 8CD71A284EE112C4	FASTA	557	61,891
	10 20 30 40 50 60 MSGDSERAVA PGVVPAPCAS KVELRLSCRH LLDRDPLTKS DPSVVLLQQA QGQWLQVDRT 70 80 90 100 110 120 EVVKSSLHPV FSKVFTVDYY FEGVQKLRFE VYDTHGPSGL TCQDDDFLGG MECTLGQIVA 130 140 150 160 170 180 QKKMTRPLLL RFGRNAGKST ITVIAEDISG NNGYVELSFQ ARKLDDKDLF SKSDPFLELY 190 200 210 220 230 240 RVNDDGSEQL VYRTEVVKNN LNPVWEPFKV SLNSLCSCEE TRPLKCLVWD YDSRGKHDFI 250 260 270 280 290 300 GDFTTTFAEM QKAFEEEQQA QWDCVNAKYK QKKRNYKNSG VVILADLKLH RVHSFLDYIM 310 320 330 340 350 360 GGCQIHCTVA IDFTASNGDP RNSCSLHHIN PYQPNEYLRA LVAVGEVCQD YDSDKRFSAL 370 380 390 400 410 420 GFGARIPPKY EVSHDFAINF NPEDDECEGI QGVVEAYQNC LPKVQLYGPT NVAPIISKVA 430 440 450 460 470 480 RMAAAEESTG EASQYYILLI LTDGVVTDMS DTREAIVRAS HLPMSVIIVG VGNADFTDMQ 490 500 510 520 530 540 ILDGDDGVLR SPRGEPALRD IVQFVPFREL KNASPAALAK CVLAEVPKQV VEYYSHKELP 550 PRSLGAQTGE AAASSAP

References

[1]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC119328 mRNA. Translation: AAI19329.1. BC137595 mRNA. Translation: AAI37596.1.
IPI	IPI00262349.
RefSeq	NP_733785.1. NM_170684.2.
UniGene	Mm.36434.
3D structure databases
ProteinModelPortal	Q0VE82.
SMR	Q0VE82. Positions 20-284.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q0VE82. 1 interaction.
PTM databases
PhosphoSite	Q0VE82.
Proteomic databases
PRIDE	Q0VE82.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000037900; ENSMUSP00000042159; ENSMUSG00000034796.
GeneID	102278.
KEGG	mmu:102278.
UCSC	uc009nuf.1. mouse.
Organism-specific databases
CTD	27132.
MGI	MGI:2142747. Cpne7.
Phylogenomic databases
eggNOG	maNOG07473.
GeneTree	ENSGT00550000074189.
HOGENOM	HBG464786.
InParanoid	Q0VE82.
OMA	LELYRVN.
OrthoDB	EOG4M3986.
PhylomeDB	Q0VE82.
Enzyme and pathway databases
Reactome	REACT_24950. Expression of Copine-7.
Gene expression databases
ArrayExpress	Q0VE82.
Bgee	Q0VE82.
Genevestigator	Q0VE82.
Family and domain databases
InterPro	IPR000008. C2_Ca-dep. IPR008973. C2_Ca/lipid-bd_dom_CaLB. IPR018029. C2_membr_targeting. IPR010734. Copine. IPR002035. VWF_A. [Graphical view]
Pfam	PF00168. C2. 2 hits. PF07002. Copine. 1 hit. [Graphical view]
SMART	SM00239. C2. 2 hits. SM00327. VWA. 1 hit. [Graphical view]
SUPFAM	SSF49562. C2_CaLB. 2 hits.
PROSITE	PS50004. C2. 2 hits. PS50234. VWFA. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	355384.
SOURCE	Search...

Entry information

Entry name

CPNE7_MOUSE

Accession

Primary (citable) accession number: Q0VE82

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 26, 2009
Last sequence update:	September 5, 2006
Last modified:	November 16, 2011
This is version 40 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program