ID   Q0VDY2_MOUSE            Unreviewed;       241 AA.
AC   Q0VDY2;
DT   05-SEP-2006, integrated into UniProtKB/TrEMBL.
DT   05-SEP-2006, sequence version 1.
DT   27-MAR-2024, entry version 87.
DE   RecName: Full=Poly(U)-binding-splicing factor PUF60 {ECO:0000256|ARBA:ARBA00018665};
DE   AltName: Full=60 kDa poly(U)-binding-splicing factor {ECO:0000256|ARBA:ARBA00031478};
DE   Flags: Fragment;
GN   Name=Puf60 {ECO:0000313|EMBL:AAI19438.1, ECO:0000313|MGI:MGI:1915209};
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090 {ECO:0000313|EMBL:AAI19438.1};
RN   [1] {ECO:0000313|EMBL:AAI19438.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=PCR rescued clones {ECO:0000313|EMBL:AAI19438.1};
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RA   Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H.,
RA   Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M.,
RA   Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.,
RA   Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F.,
RA   Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T.,
RA   Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F.,
RA   Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E.,
RA   Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y.,
RA   Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E.,
RA   Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y.,
RA   Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W.,
RA   Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J.,
RA   Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S.,
RA   Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J.,
RA   Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W.,
RA   Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J.,
RA   Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I.,
RA   Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U.,
RA   Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A.,
RA   Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
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DR   EMBL; BC119437; AAI19438.1; -; mRNA.
DR   EMBL; BC148274; AAI48275.1; -; mRNA.
DR   AlphaFoldDB; Q0VDY2; -.
DR   PeptideAtlas; Q0VDY2; -.
DR   AGR; MGI:1915209; -.
DR   MGI; MGI:1915209; Puf60.
DR   ChiTaRS; Puf60; mouse.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0000381; P:regulation of alternative mRNA splicing, via spliceosome; IEA:InterPro.
DR   CDD; cd12370; RRM1_PUF60; 1.
DR   CDD; cd12371; RRM2_PUF60; 1.
DR   Gene3D; 3.30.70.330; -; 2.
DR   InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR   InterPro; IPR006532; PUF60-like.
DR   InterPro; IPR034209; PUF60_RRM1.
DR   InterPro; IPR034211; PUF60_RRM2.
DR   InterPro; IPR035979; RBD_domain_sf.
DR   InterPro; IPR000504; RRM_dom.
DR   NCBIfam; TIGR01645; half-pint; 1.
DR   PANTHER; PTHR47330:SF1; POLY(U)-BINDING-SPLICING FACTOR PUF60; 1.
DR   PANTHER; PTHR47330; POLY(U)-BINDING-SPLICING FACTOR PUF60-B-RELATED; 1.
DR   Pfam; PF00076; RRM_1; 2.
DR   SMART; SM00360; RRM; 2.
DR   SUPFAM; SSF54928; RNA-binding domain, RBD; 2.
DR   PROSITE; PS50102; RRM; 2.
PE   2: Evidence at transcript level;
KW   mRNA processing {ECO:0000256|ARBA:ARBA00022664};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW   RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|PROSITE-
KW   ProRule:PRU00176}.
FT   DOMAIN          43..121
FT                   /note="RRM"
FT                   /evidence="ECO:0000259|PROSITE:PS50102"
FT   DOMAIN          140..218
FT                   /note="RRM"
FT                   /evidence="ECO:0000259|PROSITE:PS50102"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:AAI19438.1"
FT   NON_TER         241
FT                   /evidence="ECO:0000313|EMBL:AAI19438.1"
SQ   SEQUENCE   241 AA;  26281 MW;  E3AB053E2C3EBE4E CRC64;
     EQPQQQQQLT NLQMAAVTMG FGDPLSPLQS MAAQRQRALA IMCRVYVGSI YYELGEDTIR
     QAFAPFGPIK SIDMSWDSVT MKHKGFAFVE YEVPEAAQLA LEQMNSVMLG GRNIKVGRPS
     NIGQAQPIID QLAEEARAFN RIYVASVHQD LSDDDIKSVF EAFGKIKSCT LARDPTTGKH
     KGYGFIEYEK AQSSQDAVSS MNLFDLGGQY LRVGKAVTPP MPLLTPATPG GLPPAAAVVV
     H
//