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Q0VDV7

- Q0VDV7_MOUSE

UniProt

Q0VDV7 - Q0VDV7_MOUSE

Protein
Submitted name:

Kras protein

Gene

Kras

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 72 (01 Oct 2014)
      Sequence version 1 (05 Sep 2006)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. GTPase activity Source: MGI
    2. GTP binding Source: UniProtKB-KW
    3. protein complex binding Source: MGI

    GO - Biological processi

    1. actin cytoskeleton organization Source: MGI
    2. epithelial tube branching involved in lung morphogenesis Source: MGI
    3. negative regulation of cell differentiation Source: MGI
    4. negative regulation of neuron apoptotic process Source: MGI
    5. positive regulation of cell proliferation Source: MGI
    6. positive regulation of Rac protein signal transduction Source: MGI
    7. Ras protein signal transduction Source: MGI
    8. regulation of long-term neuronal synaptic plasticity Source: MGI
    9. regulation of synaptic transmission, GABAergic Source: MGI
    10. striated muscle cell differentiation Source: MGI
    11. visual learning Source: MGI

    Keywords - Ligandi

    GTP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Kras proteinImported
    Gene namesi
    Name:KrasImported
    OrganismiMus musculus (Mouse)Imported
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

    Organism-specific databases

    MGIiMGI:96680. Kras.

    Subcellular locationi

    GO - Cellular componenti

    1. membrane Source: MGI

    PTM / Processingi

    Proteomic databases

    PRIDEiQ0VDV7.

    Expressioni

    Gene expression databases

    ArrayExpressiQ0VDV7.
    GenevestigatoriQ0VDV7.

    Structurei

    3D structure databases

    ProteinModelPortaliQ0VDV7.
    SMRiQ0VDV7. Positions 1-166.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Phylogenomic databases

    GeneTreeiENSGT00750000117221.
    HOVERGENiHBG009351.
    InParanoidiQ0VDV7.
    KOiK07827.
    OMAiPHAASAI.
    PhylomeDBiQ0VDV7.

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    InterProiIPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    IPR001806. Small_GTPase.
    IPR020849. Small_GTPase_Ras.
    [Graphical view]
    PANTHERiPTHR24070. PTHR24070. 1 hit.
    PfamiPF00071. Ras. 1 hit.
    [Graphical view]
    PRINTSiPR00449. RASTRNSFRMNG.
    SMARTiSM00173. RAS. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    TIGRFAMsiTIGR00231. small_GTP. 1 hit.
    PROSITEiPS51421. RAS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q0VDV7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTEYKLVVVG AGGVGKSALT IQLIQNHFVD EYDPTIEDSY RKQVVIDGET    50
    CLLDILDTAG QEEYSAMRDQ YMRTGEGFLC VFAINNTKSF EDIHHYREQI 100
    KRVKDSEDVP MVLVGNKCDL PSRTVDTKQA QELARSYGIP FIETSAKTRQ 150
    RVEDAFYTLV REIRQYRLKK ISKEEKTPGC VKIKKCVIM 189
    Length:189
    Mass (Da):21,656
    Last modified:September 5, 2006 - v1
    Checksum:i97345422E01D2C81
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC119495 mRNA. Translation: AAI19496.1.
    RefSeqiXP_006506981.1. XM_006506918.1.
    XP_006536102.1. XM_006536039.1.
    UniGeneiMm.383182.

    Genome annotation databases

    GeneIDi16653.
    KEGGimmu:16653.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC119495 mRNA. Translation: AAI19496.1 .
    RefSeqi XP_006506981.1. XM_006506918.1.
    XP_006536102.1. XM_006536039.1.
    UniGenei Mm.383182.

    3D structure databases

    ProteinModelPortali Q0VDV7.
    SMRi Q0VDV7. Positions 1-166.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi Q0VDV7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 16653.
    KEGGi mmu:16653.

    Organism-specific databases

    CTDi 3845.
    MGIi MGI:96680. Kras.

    Phylogenomic databases

    GeneTreei ENSGT00750000117221.
    HOVERGENi HBG009351.
    InParanoidi Q0VDV7.
    KOi K07827.
    OMAi PHAASAI.
    PhylomeDBi Q0VDV7.

    Miscellaneous databases

    ChiTaRSi KRAS. mouse.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q0VDV7.
    Genevestigatori Q0VDV7.

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    InterProi IPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    IPR001806. Small_GTPase.
    IPR020849. Small_GTPase_Ras.
    [Graphical view ]
    PANTHERi PTHR24070. PTHR24070. 1 hit.
    Pfami PF00071. Ras. 1 hit.
    [Graphical view ]
    PRINTSi PR00449. RASTRNSFRMNG.
    SMARTi SM00173. RAS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    TIGRFAMsi TIGR00231. small_GTP. 1 hit.
    PROSITEi PS51421. RAS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
      , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: PCR rescued clonesImported.

    Entry informationi

    Entry nameiQ0VDV7_MOUSE
    AccessioniPrimary (citable) accession number: Q0VDV7
    Entry historyi
    Integrated into UniProtKB/TrEMBL: September 5, 2006
    Last sequence update: September 5, 2006
    Last modified: October 1, 2014
    This is version 72 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)