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Protein

G-protein coupled receptor 15

Gene

Gpr15

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Probable chemokine receptor.By similarity

GO - Molecular functioni

  • G-protein coupled receptor activity Source: MGI

GO - Biological processi

  • T cell migration Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-MMU-418555. G alpha (s) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
G-protein coupled receptor 15
Gene namesi
Name:Gpr15
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:1918473. Gpr15.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3333ExtracellularSequence analysisAdd
BLAST
Transmembranei34 – 5421Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini55 – 6915CytoplasmicSequence analysisAdd
BLAST
Transmembranei70 – 9021Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini91 – 12030ExtracellularSequence analysisAdd
BLAST
Transmembranei121 – 14121Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini142 – 1498CytoplasmicSequence analysis
Transmembranei150 – 17021Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini171 – 19222ExtracellularSequence analysisAdd
BLAST
Transmembranei193 – 21321Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini214 – 23926CytoplasmicSequence analysisAdd
BLAST
Transmembranei240 – 26021Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini261 – 28424ExtracellularSequence analysisAdd
BLAST
Transmembranei285 – 30521Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini306 – 36055CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 360360G-protein coupled receptor 15PRO_0000303232Add
BLAST

Proteomic databases

PaxDbiQ0VDU3.
PRIDEiQ0VDU3.

PTM databases

PhosphoSiteiQ0VDU3.

Expressioni

Gene expression databases

BgeeiQ0VDU3.
CleanExiMM_GPR15.
GenevisibleiQ0VDU3. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000086731.

Structurei

3D structure databases

ProteinModelPortaliQ0VDU3.
SMRiQ0VDU3. Positions 39-306.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IJEK. Eukaryota.
ENOG410YCV2. LUCA.
GeneTreeiENSGT00760000119055.
HOGENOMiHOG000077773.
HOVERGENiHBG101112.
InParanoidiQ0VDU3.
KOiK08403.
OMAiRRRDCAY.
OrthoDBiEOG73V6KF.
TreeFamiTF330024.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q0VDU3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEPATALLIV DYYDYTSPDP PFLETPSHLS YTSVFLPIFY TVVFLTGVVG
60 70 80 90 100
NFILMIALHF KRGNRRLIDI FIINLAASDF IFLVTVPLWM DKEASLGLWR
110 120 130 140 150
TGSFLCKGSS YVISVNMHCS VFLLTCMSMD RYLAIMHPAL AKRLRRRSSA
160 170 180 190 200
YAVCAVVWII SCVLGLPTLL SRELTHIEGK PYCAEKKPTS LKLMWGLVAL
210 220 230 240 250
ITTFFVPLLS IVTCYCCITR RLCAHYQQSG KHNKKLKKSI KIVIIAVAAF
260 270 280 290 300
TVSWVPFNTF KLLAIVSGFQ PEGLFHSEAL QLAMNVTGPL AFASSCVNPL
310 320 330 340 350
IYYVFDSYIR RAIVRCLCPC LKTHNFGSST ETSDSHLTKA LSNFIHAEDF
360
IRRRKRSVSL
Length:360
Mass (Da):40,542
Last modified:July 27, 2011 - v2
Checksum:i778268073E3EFD30
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti22 – 221F → I in AAI07230 (PubMed:15489334).Curated
Sequence conflicti22 – 221F → I in AAI07282 (PubMed:15489334).Curated
Sequence conflicti22 – 221F → I in AAI07283 (PubMed:15489334).Curated
Sequence conflicti22 – 221F → I in AAI19502 (PubMed:15489334).Curated
Sequence conflicti22 – 221F → I in AAI19503 (PubMed:15489334).Curated
Sequence conflicti22 – 221F → I in AAI19519 (PubMed:15489334).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC159200 Genomic DNA. No translation available.
BC107229 mRNA. Translation: AAI07230.1.
BC107281 mRNA. Translation: AAI07282.1.
BC107282 mRNA. Translation: AAI07283.1.
BC119501 mRNA. Translation: AAI19502.1.
BC119502 mRNA. Translation: AAI19503.1.
BC119518 mRNA. Translation: AAI19519.1.
CCDSiCCDS49879.1.
RefSeqiNP_001156427.1. NM_001162955.1.
UniGeneiMm.359970.
Mm.426544.

Genome annotation databases

EnsembliENSMUST00000089318; ENSMUSP00000086731; ENSMUSG00000047293.
GeneIDi71223.
KEGGimmu:71223.
UCSCiuc007zob.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC159200 Genomic DNA. No translation available.
BC107229 mRNA. Translation: AAI07230.1.
BC107281 mRNA. Translation: AAI07282.1.
BC107282 mRNA. Translation: AAI07283.1.
BC119501 mRNA. Translation: AAI19502.1.
BC119502 mRNA. Translation: AAI19503.1.
BC119518 mRNA. Translation: AAI19519.1.
CCDSiCCDS49879.1.
RefSeqiNP_001156427.1. NM_001162955.1.
UniGeneiMm.359970.
Mm.426544.

3D structure databases

ProteinModelPortaliQ0VDU3.
SMRiQ0VDU3. Positions 39-306.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000086731.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiQ0VDU3.

Proteomic databases

PaxDbiQ0VDU3.
PRIDEiQ0VDU3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000089318; ENSMUSP00000086731; ENSMUSG00000047293.
GeneIDi71223.
KEGGimmu:71223.
UCSCiuc007zob.1. mouse.

Organism-specific databases

CTDi2838.
MGIiMGI:1918473. Gpr15.

Phylogenomic databases

eggNOGiENOG410IJEK. Eukaryota.
ENOG410YCV2. LUCA.
GeneTreeiENSGT00760000119055.
HOGENOMiHOG000077773.
HOVERGENiHBG101112.
InParanoidiQ0VDU3.
KOiK08403.
OMAiRRRDCAY.
OrthoDBiEOG73V6KF.
TreeFamiTF330024.

Enzyme and pathway databases

ReactomeiR-MMU-418555. G alpha (s) signalling events.

Miscellaneous databases

PROiQ0VDU3.
SOURCEiSearch...

Gene expression databases

BgeeiQ0VDU3.
CleanExiMM_GPR15.
GenevisibleiQ0VDU3. MM.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiGPR15_MOUSE
AccessioniPrimary (citable) accession number: Q0VDU3
Secondary accession number(s): E9QKY6, Q3B800
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: July 27, 2011
Last modified: June 8, 2016
This is version 79 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.