Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Zinc finger protein 367

Gene

Znf367

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Transcriptional activator. Isoform 1 may be involved in transcriptional activation of erythroid genes (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri157 – 179C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri185 – 209C2H2-type 2PROSITE-ProRule annotationAdd BLAST25

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 367
Alternative name(s):
C2H2 zinc finger protein ZFF29
Gene namesi
Name:Znf367
Synonyms:Zff29, Zfp367
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:2442266. Zfp367.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002852981 – 340Zinc finger protein 367Add BLAST340

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei300PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ0VDT2.
PRIDEiQ0VDT2.

PTM databases

iPTMnetiQ0VDT2.
PhosphoSitePlusiQ0VDT2.

Expressioni

Tissue specificityi

Expressed in bone marrow and ovary.1 Publication

Developmental stagei

Highly expressed in fetal erythroid tissue. Lower expression in yolk sac.1 Publication

Gene expression databases

BgeeiENSMUSG00000044934.
CleanExiMM_ZFP367.
GenevisibleiQ0VDT2. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000050854.

Structurei

3D structure databases

ProteinModelPortaliQ0VDT2.
SMRiQ0VDT2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili299 – 332Sequence analysisAdd BLAST34

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi6 – 56Pro-richAdd BLAST51

Sequence similaritiesi

Contains 2 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri157 – 179C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri185 – 209C2H2-type 2PROSITE-ProRule annotationAdd BLAST25

Keywords - Domaini

Coiled coil, Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00670000098074.
HOGENOMiHOG000049286.
HOVERGENiHBG061619.
InParanoidiQ0VDT2.
OMAiKYWQTRE.
OrthoDBiEOG091G0H1R.
PhylomeDBiQ0VDT2.
TreeFamiTF321334.

Family and domain databases

Gene3Di3.30.160.60. 3 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF13912. zf-C2H2_6. 1 hit.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 2 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 2 hits.
PS50157. ZINC_FINGER_C2H2_2. 2 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q0VDT2-1) [UniParc]FASTAAdd to basket
Also known as: Zff29B

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MIRGAPAPMA EPPPVVFCHD SPKRVLVSVI RTTPATPPCS SVGEPEPPPP
60 70 80 90 100
LVPTSPGFSD FMVYPWRWGE NAHNVTLSPG AAGGVVSAGL PVAAELPTLR
110 120 130 140 150
GAPQSSASVA AVSGGEDEEE ASSPDSGHLK DGIRRGRPRA DTVRDLINEG
160 170 180 190 200
EHSSSRIRCN ICNRVFPREK SLQAHKRTHT GERPYLCDYP DCGKAFVQSG
210 220 230 240 250
QLKTHQRLHT GEKPFVCSEN GCLSRFTHAN RHCPKHPYAR LKREEPTDAL
260 270 280 290 300
SKHQSPDNKA AAEWLAKYWE MREQRTPTLK GKLVQKADQE QQDPLEYLQS
310 320 330 340
DEEDDEKSGA QRRLQEQRER LHGALALIEL ANLTGAPLRQ
Length:340
Mass (Da):37,453
Last modified:May 1, 2007 - v2
Checksum:i3F64E33395B7064C
GO
Isoform 2 (identifier: Q0VDT2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     268-340: Missing.

Note: No experimental confirmation available.
Show »
Length:267
Mass (Da):28,924
Checksum:iB665CB241C13458A
GO

Sequence cautioni

The sequence BAC39364 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti5A → V in AAI19533 (PubMed:15489334).Curated1
Sequence conflicti5A → V in AAI19532 (PubMed:15489334).Curated1
Sequence conflicti16V → I in AAI19533 (PubMed:15489334).Curated1
Sequence conflicti16V → I in AAI19532 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_024866268 – 340Missing in isoform 2. 1 PublicationAdd BLAST73

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK033288 mRNA. Translation: BAC28224.1.
AK041331 mRNA. Translation: BAC30909.1.
AK041361 mRNA. Translation: BAC30919.1.
AK085094 mRNA. Translation: BAC39364.1. Different initiation.
CT009717, AC158990 Genomic DNA. Translation: CAO91807.1.
CT009717, AC158990 Genomic DNA. Translation: CAO91808.1.
BC119531 mRNA. Translation: AAI19532.1.
BC119532 mRNA. Translation: AAI19533.1.
CCDSiCCDS26596.1. [Q0VDT2-1]
RefSeqiNP_780703.1. NM_175494.4. [Q0VDT2-1]
UniGeneiMm.300065.
Mm.402053.

Genome annotation databases

EnsembliENSMUST00000059817; ENSMUSP00000050854; ENSMUSG00000044934. [Q0VDT2-1]
ENSMUST00000117241; ENSMUSP00000113331; ENSMUSG00000044934. [Q0VDT2-2]
GeneIDi238673.
KEGGimmu:238673.
UCSCiuc007qyj.1. mouse. [Q0VDT2-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK033288 mRNA. Translation: BAC28224.1.
AK041331 mRNA. Translation: BAC30909.1.
AK041361 mRNA. Translation: BAC30919.1.
AK085094 mRNA. Translation: BAC39364.1. Different initiation.
CT009717, AC158990 Genomic DNA. Translation: CAO91807.1.
CT009717, AC158990 Genomic DNA. Translation: CAO91808.1.
BC119531 mRNA. Translation: AAI19532.1.
BC119532 mRNA. Translation: AAI19533.1.
CCDSiCCDS26596.1. [Q0VDT2-1]
RefSeqiNP_780703.1. NM_175494.4. [Q0VDT2-1]
UniGeneiMm.300065.
Mm.402053.

3D structure databases

ProteinModelPortaliQ0VDT2.
SMRiQ0VDT2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000050854.

PTM databases

iPTMnetiQ0VDT2.
PhosphoSitePlusiQ0VDT2.

Proteomic databases

PaxDbiQ0VDT2.
PRIDEiQ0VDT2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000059817; ENSMUSP00000050854; ENSMUSG00000044934. [Q0VDT2-1]
ENSMUST00000117241; ENSMUSP00000113331; ENSMUSG00000044934. [Q0VDT2-2]
GeneIDi238673.
KEGGimmu:238673.
UCSCiuc007qyj.1. mouse. [Q0VDT2-1]

Organism-specific databases

CTDi238673.
MGIiMGI:2442266. Zfp367.

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00670000098074.
HOGENOMiHOG000049286.
HOVERGENiHBG061619.
InParanoidiQ0VDT2.
OMAiKYWQTRE.
OrthoDBiEOG091G0H1R.
PhylomeDBiQ0VDT2.
TreeFamiTF321334.

Miscellaneous databases

PROiQ0VDT2.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000044934.
CleanExiMM_ZFP367.
GenevisibleiQ0VDT2. MM.

Family and domain databases

Gene3Di3.30.160.60. 3 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF13912. zf-C2H2_6. 1 hit.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 2 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 2 hits.
PS50157. ZINC_FINGER_C2H2_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZN367_MOUSE
AccessioniPrimary (citable) accession number: Q0VDT2
Secondary accession number(s): B1B191
, B1B192, Q8BH90, Q8BI44, Q8BI88
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: May 1, 2007
Last modified: November 2, 2016
This is version 90 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.