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Protein

Zinc finger protein 367

Gene

Znf367

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcriptional activator. Isoform 1 may be involved in transcriptional activation of erythroid genes (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri157 – 179C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri185 – 209C2H2-type 2PROSITE-ProRule annotationAdd BLAST25

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 367
Alternative name(s):
C2H2 zinc finger protein ZFF29
Gene namesi
Name:Znf367
Synonyms:Zff29, Zfp367
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:2442266 Zfp367

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002852981 – 340Zinc finger protein 367Add BLAST340

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei300PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ0VDT2
PRIDEiQ0VDT2

PTM databases

iPTMnetiQ0VDT2
PhosphoSitePlusiQ0VDT2

Expressioni

Tissue specificityi

Expressed in bone marrow and ovary.1 Publication

Developmental stagei

Highly expressed in fetal erythroid tissue. Lower expression in yolk sac.1 Publication

Gene expression databases

BgeeiENSMUSG00000044934
CleanExiMM_ZFP367
GenevisibleiQ0VDT2 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000050854

Structurei

3D structure databases

ProteinModelPortaliQ0VDT2
SMRiQ0VDT2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili299 – 332Sequence analysisAdd BLAST34

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi6 – 56Pro-richAdd BLAST51

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri157 – 179C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri185 – 209C2H2-type 2PROSITE-ProRule annotationAdd BLAST25

Keywords - Domaini

Coiled coil, Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00670000098074
HOGENOMiHOG000049286
HOVERGENiHBG061619
InParanoidiQ0VDT2
OMAiLAKYWEM
OrthoDBiEOG091G0H1R
PhylomeDBiQ0VDT2
TreeFamiTF321334

Family and domain databases

InterProiView protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 2 hits
SUPFAMiSSF57667 SSF57667, 1 hit
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 2 hits
PS50157 ZINC_FINGER_C2H2_2, 2 hits

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q0VDT2-1) [UniParc]FASTAAdd to basket
Also known as: Zff29B

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MIRGAPAPMA EPPPVVFCHD SPKRVLVSVI RTTPATPPCS SVGEPEPPPP
60 70 80 90 100
LVPTSPGFSD FMVYPWRWGE NAHNVTLSPG AAGGVVSAGL PVAAELPTLR
110 120 130 140 150
GAPQSSASVA AVSGGEDEEE ASSPDSGHLK DGIRRGRPRA DTVRDLINEG
160 170 180 190 200
EHSSSRIRCN ICNRVFPREK SLQAHKRTHT GERPYLCDYP DCGKAFVQSG
210 220 230 240 250
QLKTHQRLHT GEKPFVCSEN GCLSRFTHAN RHCPKHPYAR LKREEPTDAL
260 270 280 290 300
SKHQSPDNKA AAEWLAKYWE MREQRTPTLK GKLVQKADQE QQDPLEYLQS
310 320 330 340
DEEDDEKSGA QRRLQEQRER LHGALALIEL ANLTGAPLRQ
Length:340
Mass (Da):37,453
Last modified:May 1, 2007 - v2
Checksum:i3F64E33395B7064C
GO
Isoform 2 (identifier: Q0VDT2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     268-340: Missing.

Note: No experimental confirmation available.
Show »
Length:267
Mass (Da):28,924
Checksum:iB665CB241C13458A
GO

Sequence cautioni

The sequence BAC39364 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti5A → V in AAI19533 (PubMed:15489334).Curated1
Sequence conflicti5A → V in AAI19532 (PubMed:15489334).Curated1
Sequence conflicti16V → I in AAI19533 (PubMed:15489334).Curated1
Sequence conflicti16V → I in AAI19532 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_024866268 – 340Missing in isoform 2. 1 PublicationAdd BLAST73

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK033288 mRNA Translation: BAC28224.1
AK041331 mRNA Translation: BAC30909.1
AK041361 mRNA Translation: BAC30919.1
AK085094 mRNA Translation: BAC39364.1 Different initiation.
CT009717, AC158990 Genomic DNA Translation: CAO91807.1
CT009717, AC158990 Genomic DNA Translation: CAO91808.1
BC119531 mRNA Translation: AAI19532.1
BC119532 mRNA Translation: AAI19533.1
CCDSiCCDS26596.1 [Q0VDT2-1]
RefSeqiNP_780703.1, NM_175494.4 [Q0VDT2-1]
UniGeneiMm.300065
Mm.402053

Genome annotation databases

EnsembliENSMUST00000059817; ENSMUSP00000050854; ENSMUSG00000044934 [Q0VDT2-1]
ENSMUST00000117241; ENSMUSP00000113331; ENSMUSG00000044934 [Q0VDT2-2]
GeneIDi238673
KEGGimmu:238673
UCSCiuc007qyj.1 mouse [Q0VDT2-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiZN367_MOUSE
AccessioniPrimary (citable) accession number: Q0VDT2
Secondary accession number(s): B1B191
, B1B192, Q8BH90, Q8BI44, Q8BI88
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: May 1, 2007
Last modified: March 28, 2018
This is version 99 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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